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    ZYX zyxin [ Gallus gallus (chicken) ]

    Gene ID: 418300, updated on 3-Dec-2024

    Summary

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    Symbol
    ZYXprovided by CGNC
    Full Name
    zyxinprovided by CGNC
    Primary source
    CGNC:10889
    See related
    Ensembl:ENSGALG00010023926
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See ZYX in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (77483646..77495180, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (77684571..77696074, complement)

    Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene putative olfactory receptor 10AC1-like Neighboring gene EPH receptor A1 Neighboring gene uncharacterized LOC107054541 Neighboring gene family with sequence similarity 131 member B Neighboring gene uncharacterized LOC124417615 Neighboring gene chloride voltage-gated channel 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Zyxin regulates cell migration and differentiation in EMT during chicken AV valve morphogenesis. Li N, et al. Microsc Microanal, 2013 Aug. PMID 23742986
    2. Association of resistance to avian coccidiosis with single nucleotide polymorphisms in the zyxin gene. Hong YH, et al. Poult Sci, 2009 Mar. PMID 19211519
    3. Characterisation of chicken TES and its role in cell spreading and motility. Griffith E, et al. Cell Motil Cytoskeleton, 2004 Mar. PMID 14743347
    4. Biochemical and molecular characterization of the chicken cysteine-rich protein, a developmentally regulated LIM-domain protein that is associated with the actin cytoskeleton. Crawford AW, et al. J Cell Biol, 1994 Jan. PMID 8294495, Free PMC Article
    5. An interaction between zyxin and alpha-actinin. Crawford AW, et al. J Cell Biol, 1992 Mar. PMID 1541635, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Thus, zyxin appears to play a role as a regulator of cell migration and differentiation during epithelial-mesenchymal transformation in chicken atrioventricular valve formation.
      Title: Zyxin regulates cell migration and differentiation in EMT during chicken AV valve morphogenesis.
    2. The roles of multiple haplotypes of zyxin with resistance to experimental avian coccidiosis are reported.
      Title: Association of resistance to avian coccidiosis with single nucleotide polymorphisms in the zyxin gene.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Process Evidence Code Pubs
    involved_in integrin-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zyxin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004386.2 → NP_001004386.1  zyxin

      See identical proteins and their annotated locations for NP_001004386.1

      Status: PROVISIONAL

      Source sequence(s)
      JAENSK010000015
      UniProtKB/Swiss-Prot
      Q04584
      UniProtKB/TrEMBL
      A0A8V1A2E5
      Related
      ENSGALP00010035409.1, ENSGALT00010058285.1
      Conserved Domains (4) summary
      cd09349
      Location:319 → 405
      LIM1_Zyxin; The first LIM domain of Zyxin
      cd09353
      Location:412 → 471
      LIM2_Zyxin; The second LIM domain of Zyxin
      cd09435
      Location:472 → 538
      LIM3_Zyxin; The third LIM domain of Zyxin
      PHA03247
      Location:136 → 318
      PHA03247; large tegument protein UL36; Provisional

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      77483646..77495180 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015293446.4 → XP_015148932.1  zyxin isoform X2

      UniProtKB/TrEMBL
      A0A8V0ZWZ1
      Conserved Domains (3) summary
      cd09349
      Location:350 → 436
      LIM1_Zyxin; The first LIM domain of Zyxin
      cd09353
      Location:443 → 502
      LIM2_Zyxin; The second LIM domain of Zyxin
      cd09435
      Location:503 → 569
      LIM3_Zyxin; The third LIM domain of Zyxin

    2. XM_046939743.1 → XP_046795699.1  zyxin isoform X3

      UniProtKB/TrEMBL
      A0A8V1A2E5

    3. XM_046939727.1 → XP_046795683.1  zyxin isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZWZ1

    4. XM_046939740.1 → XP_046795696.1  zyxin isoform X2

      UniProtKB/TrEMBL
      A0A8V0ZWZ1

    5. XM_015293439.4 → XP_015148925.1  zyxin isoform X2

      UniProtKB/TrEMBL
      A0A8V0ZWZ1
      Related
      ENSGALP00010035404.1, ENSGALT00010058279.1
      Conserved Domains (3) summary
      cd09349
      Location:350 → 436
      LIM1_Zyxin; The first LIM domain of Zyxin
      cd09353
      Location:443 → 502
      LIM2_Zyxin; The second LIM domain of Zyxin
      cd09435
      Location:503 → 569
      LIM3_Zyxin; The third LIM domain of Zyxin

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      77684571..77696074 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046907752.1 → XP_046763708.1  zyxin isoform X2

      UniProtKB/TrEMBL
      A0A8V0ZWZ1

    2. XM_046907754.1 → XP_046763710.1  zyxin isoform X3

      UniProtKB/TrEMBL
      A0A8V1A2E5

    3. XM_046907751.1 → XP_046763707.1  zyxin isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZWZ1

    4. XM_046907753.1 → XP_046763709.1  zyxin isoform X2

      UniProtKB/TrEMBL
      A0A8V0ZWZ1

    5. XM_046907755.1 → XP_046763711.1  zyxin isoform X2

      UniProtKB/TrEMBL
      A0A8V0ZWZ1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04584.1 GenPept UniProtKB/Swiss-Prot:Q04584

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials