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    Grid2ip glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 170935, updated on 27-Nov-2024

    Summary

    Official Symbol
    Grid2ipprovided by MGI
    Official Full Name
    glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein 1provided by MGI
    Primary source
    MGI:MGI:2176213
    See related
    Ensembl:ENSMUSG00000010825 AllianceGenome:MGI:2176213
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Involved in regulation of postsynaptic cytosolic calcium ion concentration and regulation of postsynaptic membrane neurotransmitter receptor levels. Acts upstream of or within long-term synaptic depression. Located in synapse. Is active in cerebellar granule cell to Purkinje cell synapse; parallel fiber to Purkinje cell synapse; and postsynaptic density, intracellular component. Orthologous to human GRID2IP (Grid2 interacting protein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 7.6), frontal lobe adult (RPKM 1.2) and 5 other tissues See more
    Orthologs
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    Genomic context

    See Grid2ip in Genome Data Viewer
    Location:
    5 G2; 5 82.1 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (143343085..143377534)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (143357330..143391779)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene zinc finger, DHHC domain containing 4 Neighboring gene RIKEN cDNA 0610040B10 gene Neighboring gene STARR-seq mESC enhancer starr_14790 Neighboring gene STARR-seq mESC enhancer starr_14791 Neighboring gene predicted gene, 38736 Neighboring gene predicted gene 20635 Neighboring gene KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 Neighboring gene STARR-positive B cell enhancer mm9_chr5:144175650-144175951

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 

    General protein information

    Preferred Names
    delphilin
    Names
    GluR-delta2 philic-protein
    L-delphilin
    glutamate receptor, ionotropic, delta 2-interacting protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159321.2NP_001152793.1  delphilin isoform 1

      See identical proteins and their annotated locations for NP_001152793.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the larger isoform (1).
      Source sequence(s)
      AC118226, DQ193535
      Consensus CDS
      CCDS51689.1
      UniProtKB/Swiss-Prot
      Q0QWG9, Q6DID0, Q9ESJ5
      Related
      ENSMUSP00000106361.3, ENSMUST00000110733.9
      Conserved Domains (4) summary
      cd00992
      Location:269342
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd07354
      Location:122201
      HN_L-delphilin-R1_like; first harmonin_N_like domain (repeat 1) of L-delphilin, and related domains
      cd07355
      Location:378457
      HN_L-delphilin-R2_like; second harmonin_N_like domain (repeat 2) of L-delphilin, and related domains
      pfam02181
      Location:8121180
      FH2; Formin Homology 2 Domain
    2. NM_001347529.2NP_001334458.1  delphilin isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has an alternate 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC118226
      Consensus CDS
      CCDS84992.1
      UniProtKB/Swiss-Prot
      Q0QWG9
      Related
      ENSMUSP00000113443.2, ENSMUST00000120825.2
    3. NM_133355.2NP_579933.1  delphilin isoform 2

      See identical proteins and their annotated locations for NP_579933.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AF099933
      Consensus CDS
      CCDS19841.1
      UniProtKB/Swiss-Prot
      Q0QWG9
      Related
      ENSMUSP00000010969.9, ENSMUST00000010969.15
      Conserved Domains (3) summary
      cd00992
      Location:90163
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd07355
      Location:199278
      HN_L-delphilin-R2_like; second harmonin_N_like domain (repeat 2) of L-delphilin, and related domains
      pfam02181
      Location:6331001
      FH2; Formin Homology 2 Domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      143343085..143377534
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001038019.1: Suppressed sequence

      Description
      NM_001038019.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.