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    Nme3 NME/NM23 nucleoside diphosphate kinase 3 [ Mus musculus (house mouse) ]

    Gene ID: 79059, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Nme3provided by MGI
    Official Full Name
    NME/NM23 nucleoside diphosphate kinase 3provided by MGI
    Primary source
    MGI:MGI:1930182
    See related
    Ensembl:ENSMUSG00000073435 AllianceGenome:MGI:1930182
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ndk3; DR-nm23; Nm23-DR; Nm23-M3; 1810009F08Rik
    Summary
    Enables nucleoside diphosphate kinase activity. Predicted to be involved in DNA repair; mitochondrial fusion; and nucleoside triphosphate biosynthetic process. Located in ciliary basal body. Is expressed in several structures, including gut; hemolymphoid system gland; nervous system; respiratory system; and sensory organ. Orthologous to human NME3 (NME/NM23 nucleoside diphosphate kinase 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 47.6), kidney adult (RPKM 34.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nme3 in Genome Data Viewer
    Location:
    17 A3.3; 17 12.53 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (25115474..25116505)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (24896500..24897531)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase 8 interacting protein 3 Neighboring gene mitochondrial ribosomal protein S34 Neighboring gene essential meiotic structure-specific endonuclease subunit 2 Neighboring gene STARR-positive B cell enhancer ABC_E7499 Neighboring gene Jupiter microtubule associated homolog 2 Neighboring gene STARR-positive B cell enhancer ABC_E1500 Neighboring gene cramped chromatin regulator 1 Neighboring gene STARR-positive B cell enhancer ABC_E396

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The nucleoside diphosphate kinase gene Nme3 acts as quantitative trait locus promoting non-Mendelian inheritance. Bauer H, et al. PLoS Genet, 2012. PMID 22438820, Free PMC Article
    2. NME3 is a gatekeeper for DRP1-dependent mitophagy in hypoxia. Chen CW, et al. Nat Commun, 2024 Mar 13. PMID 38480688, Free PMC Article
    3. Deoxyribonucleotide metabolism, mutagenesis and cancer. Mathews CK. Nat Rev Cancer, 2015 Sep. PMID 26299592
    4. Expression patterns of nm23 genes during mouse organogenesis. Amrein L, et al. Cell Tissue Res, 2005 Dec. PMID 16082520
    5. Characterization of the nm23-M2, nm23-M3 and nm23-M4 mouse genes: comparison with their human orthologs. Massé K, et al. Gene, 2002 Aug 21. PMID 12383506

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NME3 is a gatekeeper for DRP1-dependent mitophagy in hypoxia.
      Title: NME3 is a gatekeeper for DRP1-dependent mitophagy in hypoxia.
    2. NME3 protein interacts with RHO signaling cascades to impair sperm motility through hyperactivation of SMOK, the wild-type form of the responder.
      Title: The nucleoside diphosphate kinase gene Nme3 acts as quantitative trait locus promoting non-Mendelian inheritance.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Potential readthrough

    Included gene: Mrps34

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleoside diphosphate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleoside diphosphate kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nucleoside diphosphate kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in CTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA repair ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in GTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in UTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dTMP biosynthetic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in mitochondrial fusion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial fusion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in nucleoside triphosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nucleoside triphosphate biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in ciliary basal body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    nucleoside diphosphate kinase 3
    Names
    NDK 3
    NDP kinase 3
    NDPKC
    expressed in non-metastatic cells 3
    non-metastatic cells 3, protein expressed in
    nucleoside diphosphate kinase C
    nucleoside diphosphate kinase DR-nm23
    NP_062704.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019730.2 → NP_062704.2  nucleoside diphosphate kinase 3 precursor

      See identical proteins and their annotated locations for NP_062704.2

      Status: VALIDATED

      Source sequence(s)
      AC166102, AK007399
      Consensus CDS
      CCDS28503.1
      UniProtKB/Swiss-Prot
      Q9D931, Q9EPA2, Q9WV85
      UniProtKB/TrEMBL
      Q9JIK8
      Related
      ENSMUSP00000024978.7, ENSMUST00000024978.7
      Conserved Domains (2) summary
      cd04413
      Location:22 → 151
      NDPk_I; Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside ...
      pfam00334
      Location:22 → 156
      NDK; Nucleoside diphosphate kinase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      25115474..25116505
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WV85.3 GenPept UniProtKB/Swiss-Prot:Q9WV85

    Gene LinkOut

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