Gm44504 predicted readthrough transcript (NMD candidate), 44504 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gm44504provided by MGI
Official Full Name: predicted readthrough transcript (NMD candidate), 44504provided by MGI
Primary source: MGI:MGI:5621304
See related: Ensembl:ENSMUSG00000015290 AllianceGenome:MGI:5621304
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tu11; Gm38419; SlcUbl4a; Slc10a3-ubl4
Summary: This locus represents naturally occurring readthrough transcription between the neighboring Slc10a3 (solute carrier family 10 (sodium/bile acid cotransporter family), member 3) and Ubl4 (ubiquitin-like 4) genes on chromosome X. While some readthrough transcripts encode a protein that is identical to the downstream gene product, at least one readthrough transcript appears to be a candidate for nonsense-mediated mRNA decay (NMD), and is unlikely to produce a protein product. [provided by RefSeq, May 2013]
Expression: Ubiquitous expression in adrenal adult (RPKM 44.9), ovary adult (RPKM 39.9) and 28 other tissues See more
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Genomic context

Location:: X A7.3; X

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (73411053..73416955, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (74367447..74373349, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein-folding chaperone binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in post-translational protein targeting to endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein stability	ISO Inferred from Sequence Orthology more info
involved_in tail-anchored membrane protein insertion into ER membrane	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of BAT3 complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ubiquitin-like protein 4A

Names: Slc10a3-Ubl4 readthrough; Slc10a3-Ubl4a readthrough transcript (NMD candidate); ubiquitin-like protein GDX

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001278271.1 → NP_001265200.1 ubiquitin-like protein 4A

See identical proteins and their annotated locations for NP_001265200.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AL807376

UniProtKB/Swiss-Prot

P21126

UniProtKB/TrEMBL

B2M0S0, Q3UK94

Related

ENSMUSP00000136070.2, ENSMUST00000178691.2

Conserved Domains (2) summary

cd01807
Location:1 → 72

Ubl_UBL4A_like; ubiquitin-like (Ubl) domain found in ubiquitin-like proteins UBL4A and similar proteins

pfam17840
Location:96 → 142

Tugs; Tethering Ubl4a to BAGS domain
NM_001278272.1 → NP_001265201.1 ubiquitin-like protein 4A

See identical proteins and their annotated locations for NP_001265201.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AL807376

UniProtKB/Swiss-Prot

P21126

UniProtKB/TrEMBL

B2M0S0, Q3UK94

Conserved Domains (2) summary

cd01807
Location:1 → 72

Ubl_UBL4A_like; ubiquitin-like (Ubl) domain found in ubiquitin-like proteins UBL4A and similar proteins

pfam17840
Location:96 → 142

Tugs; Tethering Ubl4a to BAGS domain

RNA

NR_103489.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an internal exon compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region found in variant 1.

Source sequence(s)

AL807376