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    Clk4 CDC-like kinase 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287269, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Clk4provided by RGD
    Official Full Name
    CDC-like kinase 4provided by RGD
    Primary source
    RGD:1310274
    See related
    EnsemblRapid:ENSRNOG00000003714 AllianceGenome:RGD:1310274
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein serine/threonine kinase activity and protein tyrosine kinase activity. Predicted to be involved in regulation of RNA splicing. Predicted to act upstream of or within peptidyl-tyrosine phosphorylation and protein autophosphorylation. Predicted to be active in nucleus. Orthologous to human CLK4 (CDC like kinase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 235.7), Thymus (RPKM 232.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Clk4 in Genome Data Viewer
    Location:
    10q22
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (36024364..36042366)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (35523382..35541387)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (36715565..36733473)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene Myb/SANT DNA binding domain containing 5 like 1 Neighboring gene putative uncharacterized protein MSANTD5 Neighboring gene Myb/SANT DNA binding domain containing 5 Neighboring gene collagen type XXIII alpha 1 chain Neighboring gene uncharacterized LOC120095095 Neighboring gene uncharacterized LOC134480786

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells. Eisenreich A, et al. Circ Res, 2009 Mar 13. PMID 19168442
    2. Characterization and comparison of four serine- and arginine-rich (SR) protein kinases. Nayler O, et al. Biochem J, 1997 Sep 15. PMID 9307018, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of RNA splicing ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dual specificity protein kinase CLK4
    NP_001013059.1
    NP_001386357.1
    NP_001386358.1
    XP_006246299.1
    XP_008765894.1
    XP_038941309.1
    XP_038941310.1
    XP_038941311.1
    XP_063124653.1
    XP_063124654.1
    XP_063124655.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013041.1 → NP_001013059.1  dual specificity protein kinase CLK4 isoform 3

      See identical proteins and their annotated locations for NP_001013059.1

      Status: VALIDATED

      Source sequence(s)
      BC079006
      UniProtKB/TrEMBL
      A6HE53, Q6AYK7
      Conserved Domains (1) summary
      cl21453
      Location:1 → 295
      PKc_like; Protein Kinases, catalytic domain

    2. NM_001399428.1 → NP_001386357.1  dual specificity protein kinase CLK4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I5ZNT1, A6HE48
      Related
      ENSRNOP00000079861.1, ENSRNOT00000119764.2
      Conserved Domains (1) summary
      cd14213
      Location:146 → 475
      PKc_CLK1_4; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases 1 and 4

    3. NM_001399429.1 → NP_001386358.1  dual specificity protein kinase CLK4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A6HE49, F7ETQ4
      Related
      ENSRNOP00000103479.1, ENSRNOT00000132107.1
      Conserved Domains (1) summary
      cd14213
      Location:110 → 439
      PKc_CLK1_4; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases 1 and 4

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      36024364..36042366
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063268583.1 → XP_063124653.1  dual specificity protein kinase CLK4 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZNT1, A6HE48

    2. XM_039085382.2 → XP_038941310.1  dual specificity protein kinase CLK4 isoform X1

      Related
      ENSRNOP00000005048.7, ENSRNOT00000005048.7
      Conserved Domains (1) summary
      cd14213
      Location:172 → 501
      PKc_CLK1_4; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases 1 and 4

    3. XM_039085381.2 → XP_038941309.1  dual specificity protein kinase CLK4 isoform X1

      Conserved Domains (1) summary
      cd14213
      Location:172 → 501
      PKc_CLK1_4; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases 1 and 4

    4. XM_063268585.1 → XP_063124655.1  dual specificity protein kinase CLK4 isoform X5

    5. XM_006246237.4 → XP_006246299.1  dual specificity protein kinase CLK4 isoform X3

      See identical proteins and their annotated locations for XP_006246299.1

      UniProtKB/TrEMBL
      A6HE49, F7ETQ4
      Related
      ENSRNOP00000106785.1, ENSRNOT00000162431.1
      Conserved Domains (1) summary
      cd14213
      Location:110 → 439
      PKc_CLK1_4; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases 1 and 4

    6. XM_063268584.1 → XP_063124654.1  dual specificity protein kinase CLK4 isoform X4

      UniProtKB/TrEMBL
      A6HE53, Q6AYK7

    7. XM_039085383.2 → XP_038941311.1  dual specificity protein kinase CLK4 isoform X4

      UniProtKB/TrEMBL
      A6HE53, Q6AYK7
      Conserved Domains (1) summary
      cl21453
      Location:1 → 295
      PKc_like; Protein Kinases, catalytic domain

    8. XM_008767672.4 → XP_008765894.1  dual specificity protein kinase CLK4 isoform X3

      See identical proteins and their annotated locations for XP_008765894.1

      UniProtKB/TrEMBL
      A6HE49, F7ETQ4
      Conserved Domains (1) summary
      cd14213
      Location:110 → 439
      PKc_CLK1_4; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases 1 and 4
    Nucleotide Protein Strain
    Heading Accession and Version

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