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    INTS3 integrator complex subunit 3 [ Homo sapiens (human) ]

    Gene ID: 65123, updated on 10-Dec-2024

    Summary

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    Official Symbol
    INTS3provided by HGNC
    Official Full Name
    integrator complex subunit 3provided by HGNC
    Primary source
    HGNC:HGNC:26153
    See related
    Ensembl:ENSG00000143624 MIM:611347; AllianceGenome:HGNC:26153
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    INT3; SOSSA; SOSS-A; C1orf60; C1orf193
    Summary
    The protein encoded by this gene can form a complex with human single-strand DNA binding proteins 1 or 2 (hSSB1 and hSSB2) and other proteins to mediate genome stability and the DNA damage response. The encoded protein is also part of a multiprotein complex that interacts with the C-terminal domain of RNA polymerase II large subunit to help regulate processing of U1 and U2 small nuclear RNAs. [provided by RefSeq, May 2016]
    Expression
    Ubiquitous expression in testis (RPKM 20.6), ovary (RPKM 17.9) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See INTS3 in Genome Data Viewer
    Location:
    1q21.3
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (153728050..153774808)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (152865319..152912062)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (153700526..153747284)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene natriuretic peptide receptor 1 Neighboring gene microRNA 8083 Neighboring gene gem nuclear organelle associated protein 2 pseudogene 1 Neighboring gene RNA, 7SL, cytoplasmic 372, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr1:153700292-153700463 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:153706223-153706722 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:153717251-153717990 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:153717991-153718730 Neighboring gene small nucleolar RNA U13 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:153748284-153748950 Neighboring gene solute carrier family 27 member 3 Neighboring gene uncharacterized LOC124904424 Neighboring gene uncharacterized LOC124904426

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The Integrator complex controls the termination of transcription at diverse classes of gene targets. Skaar JR, et al. Cell Res, 2015 Mar. PMID 25675981, Free PMC Article
    2. Subnuclear domain proteins in cancer cells support the functions of RUNX2 in the DNA damage response. Yang S, et al. J Cell Sci, 2015 Feb 15. PMID 25609707, Free PMC Article
    3. Structural basis for multifunctional roles of human Ints3 C-terminal domain. Li J, et al. J Biol Chem, 2021 Jan-Jun. PMID 33434574, Free PMC Article
    4. Biochemical characterization of INTS3 and C9ORF80, two subunits of hNABP1/2 heterotrimeric complex in nucleic acid binding. Vidhyasagar V, et al. Biochem J, 2018 Jan 2. PMID 29150435, Free PMC Article
    5. INTS3 controls the hSSB1-mediated DNA damage response. Skaar JR, et al. J Cell Biol, 2009 Oct 5. PMID 19786574, Free PMC Article

    See all (84) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. INTS3, but not C9ORF80, affects the nucleic acid-binding ability of hNABP1 and hNABP2, indicating that INTS3 might regulate hNABP1/hNABP2 biological function, while the role of C9ORF80 remains unknown.
      Title: Biochemical characterization of INTS3 and C9ORF80, two subunits of hNABP1/2 heterotrimeric complex in nucleic acid binding.
    2. In response to the DNA damage response, INTS3-hSSB1-INTS6 complex relocates to the DNA damage sites.
      Title: A core hSSB1-INTS complex participates in the DNA damage response.
    3. INT3 plays a key role in the DNA damage response
      Title: Integrator3, a partner of single-stranded DNA-binding protein 1, participates in the DNA damage response.
    4. INTS3 controls the hSSB1-mediated DNA damage response.
      Title: INTS3 controls the hSSB1-mediated DNA damage response.
    5. INTS3 is part of an ssDNA-binding heterotrimeric complex, SOSS which is involved in the maintenance of genome stability.
      Title: SOSS complexes participate in the maintenance of genomic stability.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ21919, FLJ44849, DKFZp686E1950, DKFZp781I1253, DKFZp686O20115

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in double-strand break repair via homologous recombination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitotic G2/M transition checkpoint IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitotic G2/M transition checkpoint IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription elongation by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in response to ionizing radiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in snRNA processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in snRNA processing NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SOSS complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SOSS complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of integrator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of integrator complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in site of double-strand break IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    integrator complex subunit 3
    Names
    SOSS complex subunit A
    sensor of single-strand DNA complex subunit A
    sensor of ssDNA subunit A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_050682.2 RefSeqGene

      Range
      5002..51760
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001324475.2 → NP_001311404.1  integrator complex subunit 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AK290025, AL513523, BX110564, CR749376
      Consensus CDS
      CCDS1052.1
      UniProtKB/Swiss-Prot
      A8K1W0, B4DQC8, B4E3U9, D3DV57, Q4G0E5, Q5VUQ5, Q5VUQ6, Q5VUR0, Q5VUR1, Q68DJ1, Q68E01, Q69YR5, Q6AI57, Q6DKG7, Q6MZQ4, Q6MZZ9, Q8NC46, Q8TB23, Q9H6S9
      Related
      ENSP00000404290.2, ENST00000435409.6
      Conserved Domains (1) summary
      pfam10189
      Location:270 → 494
      Ints3; Integrator complex subunit 3

    2. NM_023015.5 → NP_075391.3  integrator complex subunit 3

      See identical proteins and their annotated locations for NP_075391.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AL513523
      Consensus CDS
      CCDS1052.1
      UniProtKB/Swiss-Prot
      A8K1W0, B4DQC8, B4E3U9, D3DV57, Q4G0E5, Q5VUQ5, Q5VUQ6, Q5VUR0, Q5VUR1, Q68DJ1, Q68E01, Q69YR5, Q6AI57, Q6DKG7, Q6MZQ4, Q6MZZ9, Q8NC46, Q8TB23, Q9H6S9
      Related
      ENSP00000318641.2, ENST00000318967.7
      Conserved Domains (1) summary
      pfam10189
      Location:270 → 494
      Ints3; Integrator complex subunit 3

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      153728050..153774808
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NW_003315905.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      44751..91509
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      152865319..152912062
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q68E01.1 GenPept UniProtKB/Swiss-Prot:Q68E01

    Gene LinkOut

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