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    tin-9.2 Mitochondrial import inner membrane translocase subunit Tim10B [ Caenorhabditis elegans ]

    Gene ID: 24105311, updated on 4-Jan-2025

    Summary

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    Official Symbol
    tin-9.2
    Official Full Name
    Mitochondrial import inner membrane translocase subunit Tim10B
    Primary source
    WormBase:WBGene00044083
    Locus tag
    CELE_TIN-9.2
    See related
    AllianceGenome:WB:WBGene00044083
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable metal ion binding activity. Involved in inductive cell migration and regulation of growth. Located in mitochondrion. Orthologous to human TIMM10B (translocase of inner mitochondrial membrane 10B). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

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    See tin-9.2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    5
    Sequence:
    Chromosome: IV; NC_003282.8 (13099005..13100582)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene SAP domain-containing protein Neighboring gene Replication factor C subunit 3 Neighboring gene Dynein light intermediate chain Neighboring gene Putative exosome complex component RRP41 Neighboring gene RAP domain-containing protein Neighboring gene RNA interference defective protein 11

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Defective mitochondrial protein translocation precludes normal Caenorhabditis elegans development. Curran SP, et al. J Biol Chem, 2004 Dec 24. PMID 15485840
    2. The effects of plant cysteine proteinases on the nematode cuticle. Njom VS, et al. Parasit Vectors, 2021 Jun 5. PMID 34090505, Free PMC Article
    3. Caenorhabditis elegans as a model system to study intercompartmental proteostasis: Interrelation of mitochondrial function, longevity, and neurodegenerative diseases. Kirstein-Miles J, et al. Dev Dyn, 2010 May. PMID 20419784, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in inductive cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in reproductive process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mitochondrial import inner membrane translocase subunit Tim10B
    NP_001368153.1
    • Partially confirmed by transcript evidence
    NP_001379430.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      13099005..13100582
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392423.1 → NP_001379430.1  Mitochondrial import inner membrane translocase subunit Tim10B [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q5FC56, Q9Y0V2
      Conserved Domains (1) summary
      pfam02953
      Location:4 → 63
      zf-Tim10_DDP; Tim10/DDP family zinc finger

    2. NM_001380504.1 → NP_001368153.1  Mitochondrial import inner membrane translocase subunit Tim10B [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      J7SF95
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y0V2.1

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