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    Mbnl2 muscleblind-like splicing regulator 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 680445, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mbnl2provided by RGD
    Official Full Name
    muscleblind-like splicing regulator 2provided by RGD
    Primary source
    RGD:1591755
    See related
    EnsemblRapid:ENSRNOG00000010737 AllianceGenome:RGD:1591755
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable RNA binding activity and sequence-specific double-stranded DNA binding activity. Involved in regulation of alternative mRNA splicing, via spliceosome. Predicted to be active in cytoplasm and nucleoplasm. Orthologous to human MBNL2 (muscleblind like splicing regulator 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 537.2), Muscle (RPKM 531.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mbnl2 in Genome Data Viewer
    Location:
    15q24
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (103792134..103949827)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (97385278..97542924)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (105640097..105797933)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102551086 Neighboring gene uncharacterized LOC120097085 Neighboring gene uncharacterized LOC120097086 Neighboring gene uncharacterized LOC120097087 Neighboring gene uncharacterized LOC120097088 Neighboring gene RAP2A, member of RAS oncogene family

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Muscleblind-like 2: circadian expression in the mammalian pineal gland is controlled by an adrenergic-cAMP mechanism. Kim JS, et al. J Neurochem, 2009 Jul. PMID 19457059, Free PMC Article
    2. Identification of RBPMS as a mammalian smooth muscle master splicing regulator via proximity of its gene with super-enhancers. Nakagaki-Silva EE, et al. Elife, 2019 Jul 8. PMID 31283468, Free PMC Article
    3. Muscleblind proteins regulate alternative splicing. Ho TH, et al. EMBO J, 2004 Aug 4. PMID 15257297, Free PMC Article
    4. MBNL and CELF proteins regulate alternative splicing of the skeletal muscle chloride channel CLCN1. Kino Y, et al. Nucleic Acids Res, 2009 Oct. PMID 19720736, Free PMC Article
    5. Interaction of muscleblind, CUG-BP1 and hnRNP H proteins in DM1-associated aberrant IR splicing. Paul S, et al. EMBO J, 2006 Sep 20. PMID 16946708, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of RNA splicing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    muscleblind-like protein 2
    Names
    muscleblind-like 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001111064.2 → NP_001104534.1  muscleblind-like protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001104534.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/Swiss-Prot
      F2Z3T4
      UniProtKB/TrEMBL
      A6HUI3
      Related
      ENSRNOP00000014300.7, ENSRNOT00000014300.9
      Conserved Domains (1) summary
      smart00356
      Location:178 → 202
      ZnF_C3H1; zinc finger

    2. NM_001415043.1 → NP_001401972.1  muscleblind-like protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A0A8I5Y5P3, A6HUI2
      Related
      ENSRNOP00000077342.1, ENSRNOT00000109835.2

    3. NM_001415044.1 → NP_001401973.1  muscleblind-like protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A0A8I6AKC8, A6HUI3
      Related
      ENSRNOP00000094173.1, ENSRNOT00000116108.2

    4. NM_001415045.1 → NP_001401974.1  muscleblind-like protein 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A6HUI2
      Related
      ENSRNOP00000089857.2, ENSRNOT00000095906.2

    5. NM_001415046.1 → NP_001401975.1  muscleblind-like protein 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A6HUI3

    6. NM_001415047.1 → NP_001401976.1  muscleblind-like protein 2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A6HUI3
      Related
      ENSRNOP00000112436.1, ENSRNOT00000160527.1

    7. NM_001415048.1 → NP_001401977.1  muscleblind-like protein 2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A6HUI3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      103792134..103949827
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063274619.1 → XP_063130689.1  muscleblind-like protein 2 isoform X1

      UniProtKB/TrEMBL
      A6HUI3

    2. XM_063274622.1 → XP_063130692.1  muscleblind-like protein 2 isoform X2

      UniProtKB/TrEMBL
      A6HUI3
      Related
      ENSRNOP00000099124.1, ENSRNOT00000173246.1

    3. XM_063274626.1 → XP_063130696.1  muscleblind-like protein 2 isoform X5

      UniProtKB/TrEMBL
      A6HUI3

    4. XM_063274620.1 → XP_063130690.1  muscleblind-like protein 2 isoform X1

      UniProtKB/TrEMBL
      A6HUI3

    5. XM_063274621.1 → XP_063130691.1  muscleblind-like protein 2 isoform X1

      UniProtKB/TrEMBL
      A6HUI3

    6. XM_063274624.1 → XP_063130694.1  muscleblind-like protein 2 isoform X3

      UniProtKB/TrEMBL
      A6HUI2

    7. XM_063274625.1 → XP_063130695.1  muscleblind-like protein 2 isoform X4

      UniProtKB/TrEMBL
      A6HUI3
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F2Z3T4.1 GenPept UniProtKB/Swiss-Prot:F2Z3T4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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