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    Wars1 tryptophanyl-tRNA synthetase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314442, updated on 9-Dec-2024

    Summary

    Official Symbol
    Wars1provided by RGD
    Official Full Name
    tryptophanyl-tRNA synthetase 1provided by RGD
    Primary source
    RGD:1308278
    See related
    EnsemblRapid:ENSRNOG00000004359 AllianceGenome:RGD:1308278
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Wars
    Summary
    Predicted to enable several functions, including kinase inhibitor activity; protein homodimerization activity; and tryptophan-tRNA ligase activity. Predicted to be involved in several processes, including negative regulation of protein kinase activity; regulation of angiogenesis; and tryptophanyl-tRNA aminoacylation. Predicted to be located in cytosol and nucleus. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in autosomal dominant distal hereditary motor neuronopathy 9. Orthologous to human WARS1 (tryptophanyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 100.1), Brain (RPKM 74.7) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Wars1 in Genome Data Viewer
    Location:
    6q32
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (133540463..133571645, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (127776088..127807273, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (132771026..132802262, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479257 Neighboring gene microRNA 345 Neighboring gene solute carrier family 25, member 47 Neighboring gene WD repeat domain 25 Neighboring gene brain-enriched guanylate kinase-associated

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables tryptophan-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables tryptophan-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables tryptophan-tRNA ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables tryptophan-tRNA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tryptophanyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in tryptophanyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in tryptophanyl-tRNA aminoacylation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    tryptophan--tRNA ligase, cytoplasmic
    Names
    trpRS
    tryptophanyl-tRNA synthetase, cytoplasmic
    NP_001013188.2
    XP_038968331.1
    XP_038968332.1
    XP_063118081.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013170.2NP_001013188.2  tryptophan--tRNA ligase, cytoplasmic

      Status: VALIDATED

      Source sequence(s)
      AY724504
      UniProtKB/TrEMBL
      A6KBI0
      Related
      ENSRNOP00000049063.3, ENSRNOT00000050350.7
      Conserved Domains (3) summary
      PLN02486
      Location:89470
      PLN02486; aminoacyl-tRNA ligase
      TIGR00233
      Location:158467
      trpS; tryptophanyl-tRNA synthetase
      pfam00458
      Location:1668
      WHEP-TRS; WHEP-TRS domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      133540463..133571645 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039112404.2XP_038968332.1  tryptophan--tRNA ligase, cytoplasmic isoform X1

      UniProtKB/TrEMBL
      A6KBI0, F8WFH8
      Conserved Domains (2) summary
      PLN02486
      Location:89470
      PLN02486; aminoacyl-tRNA ligase
      cd00936
      Location:1665
      WEPRS_RNA; WEPRS_RNA binding domain. This short RNA-binding domain is found in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). It is found in multiple copies in eukaryotic bifunctional glutamyl-prolyl-tRNA synthetases (EPRS) in a region that separates ...
    2. XM_039112403.2XP_038968331.1  tryptophan--tRNA ligase, cytoplasmic isoform X1

      UniProtKB/TrEMBL
      A6KBI0, F8WFH8
      Conserved Domains (2) summary
      PLN02486
      Location:89470
      PLN02486; aminoacyl-tRNA ligase
      cd00936
      Location:1665
      WEPRS_RNA; WEPRS_RNA binding domain. This short RNA-binding domain is found in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). It is found in multiple copies in eukaryotic bifunctional glutamyl-prolyl-tRNA synthetases (EPRS) in a region that separates ...
    3. XM_063262011.1XP_063118081.1  tryptophan--tRNA ligase, cytoplasmic isoform X2

      UniProtKB/TrEMBL
      A6KBI0
      Related
      ENSRNOP00000073702.1, ENSRNOT00000080163.3