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    CYP4F11 cytochrome P450 family 4 subfamily F member 11 [ Homo sapiens (human) ]

    Gene ID: 57834, updated on 27-Nov-2024

    Summary

    Official Symbol
    CYP4F11provided by HGNC
    Official Full Name
    cytochrome P450 family 4 subfamily F member 11provided by HGNC
    Primary source
    HGNC:HGNC:13265
    See related
    Ensembl:ENSG00000171903 MIM:611517; AllianceGenome:HGNC:13265
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CYPIVF11
    Summary
    This gene, CYP4F11, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F2, is approximately 16 kb away. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in liver (RPKM 19.6), gall bladder (RPKM 11.3) and 11 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CYP4F11 in Genome Data Viewer
    Location:
    19p13.12
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (15912377..15934867, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (16043606..16068596, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (16023187..16045677, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene RNA polymerase mitochondrial pseudogene Neighboring gene RNA polymerase mitochondrial pseudogene Neighboring gene inositol polyphosphate multikinase pseudogene Neighboring gene olfactory receptor family 10 subfamily H member 4 Neighboring gene cytochrome P450 4F2-like Neighboring gene cytochrome P450 family 4 subfamily F member 9, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of cytochrome P450, family 4, subfamily F, polypeptide 11 (CYP4F11) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in arachidonate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in blood coagulation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cytochrome metabolic process TAS
    Traceable Author Statement
    more info
     
    involved_in fatty acid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in menaquinone catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in menaquinone catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in omega-hydroxylase P450 pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in oxylipin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phylloquinone catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phylloquinone catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in phylloquinone catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vitamin K catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    cytochrome P450 4F11
    Names
    3-hydroxy fatty acids omega-hydroxylase CYP4F11
    cytochrome P450, family 4, subfamily F, polypeptide 11
    cytochrome P450, subfamily IVF, polypeptide 11
    docosahexaenoic acid omega-hydroxylase
    long-chain fatty acid omega-monooxygenase
    phylloquinone omega-hydroxylase CYP4F11
    NP_001122404.1
    NP_067010.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008335.2 RefSeqGene

      Range
      5338..27490
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001128932.2NP_001122404.1  cytochrome P450 4F11

      See identical proteins and their annotated locations for NP_001122404.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an internal segment in the 5' UTR, as compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC005336, AC011517, AC020950
      Consensus CDS
      CCDS12337.1
      UniProtKB/Swiss-Prot
      A0A024R7G0, A8K059, O75254, Q96AQ5, Q9HBI6
      Related
      ENSP00000248041.6, ENST00000248041.12
      Conserved Domains (1) summary
      pfam00067
      Location:52506
      p450; Cytochrome P450
    2. NM_021187.4NP_067010.3  cytochrome P450 4F11

      See identical proteins and their annotated locations for NP_067010.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is the longer transcript.
      Source sequence(s)
      AC005336, AC011517, AC020950
      Consensus CDS
      CCDS12337.1
      UniProtKB/Swiss-Prot
      A0A024R7G0, A8K059, O75254, Q96AQ5, Q9HBI6
      Related
      ENSP00000384588.2, ENST00000402119.9
      Conserved Domains (1) summary
      pfam00067
      Location:52506
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      15912377..15934867 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      16043606..16068596 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)