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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
mRNA and Protein(s)
-
NM_001281976.1 → NP_001268905.1 cytotoxic T-lymphocyte protein 4 isoform 2 precursor
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) lacks the penultimate coding exon, which results in a frame-shift and early translation termination compared to variant 1. The resulting shorter isoform (2, also known as sCTLA-4) with a distinct C-terminus, lacks the transmembrane domain and is secreted (PMIDs: 10831323, 23400950).
- Source sequence(s)
-
AI323635, AK138891, AL663047
- Consensus CDS
-
CCDS69893.1
- UniProtKB/TrEMBL
-
Q5SSM0
- Related
- ENSMUSP00000095327.4, ENSMUST00000097720.4
- Conserved Domains (2) summary
-
- cd05721
Location:39 → 152
- IgV_CTLA-4; Immunoglobulin (Ig) domain of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4)
- smart00410
Location:43 → 132
- IG_like; Immunoglobulin like
-
NM_009843.4 → NP_033973.2 cytotoxic T-lymphocyte protein 4 isoform 1 precursor
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) encodes the longer membrane-bound isoform (1).
- Source sequence(s)
-
AI323635, AK138891, AL663047
- Consensus CDS
-
CCDS14993.1
- UniProtKB/Swiss-Prot
- P09793, Q9QZZ7
- UniProtKB/TrEMBL
- Q6GTR6, Q7TMX1
- Related
- ENSMUSP00000027164.3, ENSMUST00000027164.9
- Conserved Domains (2) summary
-
- cd05721
Location:39 → 152
- IgV_CTLA-4; Immunoglobulin (Ig) domain of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4)
- smart00410
Location:43 → 132
- IG_like; Immunoglobulin like
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCm39 C57BL/6J
Genomic
-
NC_000067.7 Reference GRCm39 C57BL/6J
- Range
-
60948184..60954991
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_036156357.1 → XP_036012250.1 cytotoxic T-lymphocyte protein 4 isoform X1
- Conserved Domains (2) summary
-
- cd00096
Location:1 → 9
- Ig; Ig strand C' [structural motif]
- cl11960
Location:1 → 73
- Ig; Immunoglobulin domain