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    ARHGAP26 Rho GTPase activating protein 26 [ Gallus gallus (chicken) ]

    Gene ID: 396113, updated on 3-Dec-2024

    Summary

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    Official Symbol
    ARHGAP26provided by CGNC
    Official Full Name
    Rho GTPase activating protein 26provided by CGNC
    Primary source
    CGNC:49657
    See related
    Ensembl:ENSGALG00010016732
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    GRAF
    Orthologs
    human mouse all
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    Genomic context

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    See ARHGAP26 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 13 NC_052544.1 (16891698..16992475)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 13 NC_052585.1 (16903820..17004652)

    Chromosome 13 - NC_052544.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101749811 Neighboring gene uncharacterized LOC121106695 Neighboring gene fibroblast growth factor 1 Neighboring gene nuclear receptor subfamily 3 group C member 1 Neighboring gene microRNA 6588 Neighboring gene Yip1 domain family member 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An SH3 domain-containing GTPase-activating protein for Rho and Cdc42 associates with focal adhesion kinase. Hildebrand JD, et al. Mol Cell Biol, 1996 Jun. PMID 8649427, Free PMC Article
    2. Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis. Caldwell RB, et al. Genome Biol, 2005. PMID 15642098, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rho GTPase-activating protein 26
    Names
    GTPase regulator associated with FAK
    GTPase regulator associated with focal adhesion kinase
    rho-type GTPase-activating protein 26
    rhoGap protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_205194.3 → NP_990525.3  rho GTPase-activating protein 26

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000256
      UniProtKB/Swiss-Prot
      Q5ZMW5, Q98935
      UniProtKB/TrEMBL
      A0A8V0YZ51
      Related
      ENSGALP00010023414.1, ENSGALT00010040366.1
      Conserved Domains (4) summary
      cd12064
      Location:705 → 760
      SH3_GRAF; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase
      cd04374
      Location:364 → 563
      RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...
      cd01249
      Location:267 → 371
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      cl12013
      Location:19 → 225
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052544.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      16891698..16992475
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015294012.4 → XP_015149498.1  rho GTPase-activating protein 26 isoform X2

      UniProtKB/TrEMBL
      A0A1D5PAP4, A0A8V0YZ51
      Related
      ENSGALP00010023425.1, ENSGALT00010040380.1
      Conserved Domains (5) summary
      cd07636
      Location:19 → 225
      BAR_GRAF; The Bin/Amphiphysin/Rvs (BAR) domain of GTPase Regulator Associated with Focal adhesion kinase
      cd12064
      Location:668 → 723
      SH3_GRAF; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase
      cd04374
      Location:364 → 563
      RhoGAP_Graf; RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences ...
      cd01249
      Location:267 → 371
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      pfam00169
      Location:267 → 364
      PH; PH domain

    2. XM_015294013.4 → XP_015149499.2  rho GTPase-activating protein 26 isoform X3

      UniProtKB/TrEMBL
      A0A8V0YZ51
      Related
      ENSGALP00010023390.1, ENSGALT00010040331.1
      Conserved Domains (3) summary
      cd04374
      Location:364 → 563
      RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...
      cd01249
      Location:267 → 371
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      cl12013
      Location:19 → 225
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    3. XM_040646858.2 → XP_040502792.1  rho GTPase-activating protein 26 isoform X1

      UniProtKB/TrEMBL
      A0A8V0YQV7, A0A8V0YZ51
      Related
      ENSGALP00010023397.1, ENSGALT00010040343.1
      Conserved Domains (4) summary
      cd12064
      Location:674 → 729
      SH3_GRAF; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase
      cd04374
      Location:333 → 532
      RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...
      cd01249
      Location:236 → 340
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      cl12013
      Location:13 → 194
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052585.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      16903820..17004652
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046926872.1 → XP_046782828.1  rho GTPase-activating protein 26 isoform X2

      UniProtKB/TrEMBL
      A0A1D5PAP4, A0A8V0YZ51

    2. XM_046926873.1 → XP_046782829.1  rho GTPase-activating protein 26 isoform X3

      UniProtKB/TrEMBL
      A0A8V0YZ51

    3. XM_046926871.1 → XP_046782827.1  rho GTPase-activating protein 26 isoform X1

      UniProtKB/TrEMBL
      A0A8V0YQV7, A0A8V0YZ51
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5ZMW5.2 GenPept UniProtKB/Swiss-Prot:Q5ZMW5

    Gene LinkOut

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