CARD11 caspase recruitment domain family member 11 [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: CARD11provided by CGNC
Official Full Name: caspase recruitment domain family member 11provided by CGNC
Primary source: CGNC:50263
See related: Ensembl:ENSGALG00010017184
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: CARMA1
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 14

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	14	NC_052545.1 (3433403..3473539, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	14	NC_052586.1 (3431639..3471796, complement)

Chromosome 14 - NC_052545.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

found that antigen receptor-activated CARMA1 underwent lysine 48 (K48) polyubiquitination and proteasome-dependent degradation.
Title: MAGUK-controlled ubiquitination of CARMA1 modulates lymphocyte NF-kappaB activity.
IkappaB kinase beta-induced phosphorylation of CARMA1 contributes to CARMA1 Bcl10 MALT1 complex formation in B cells
Title: IkappaB kinase beta-induced phosphorylation of CARMA1 contributes to CARMA1 Bcl10 MALT1 complex formation in B cells.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of apoptotic process	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: caspase recruitment domain-containing protein 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001006161.4 → NP_001006161.3 caspase recruitment domain-containing protein 11

Status: PROVISIONAL

Source sequence(s)

JAENSK010000257

UniProtKB/TrEMBL

Q5F3W0

Related

ENSGALP00010024287.1, ENSGALT00010041469.1

Conserved Domains (5) summary

COG1196
Location:129 → 419

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd08808
Location:24 → 109

CARD_CARD11_CARMA1; Caspase activation and recruitment domain of CARD11-like proteins

cl00117
Location:716 → 768

PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...

cl17036
Location:809 → 858

SH3; Src Homology 3 domain superfamily

cl17190
Location:1025 → 1159

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052545.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

3433403..3473539 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_040647347.1 → XP_040503281.1 caspase recruitment domain-containing protein 11 isoform X2

UniProtKB/TrEMBL

Q5F3W0

Conserved Domains (5) summary

COG1196
Location:180 → 470

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd08808
Location:75 → 160

CARD_CARD11_CARMA1; Caspase activation and recruitment domain of CARD11-like proteins

cl00117
Location:766 → 818

PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...

cl17036
Location:859 → 908

SH3; Src Homology 3 domain superfamily

cl17190
Location:1075 → 1209

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
XM_015294162.3 → XP_015149648.2 caspase recruitment domain-containing protein 11 isoform X1

UniProtKB/TrEMBL

Q5F3W0

Conserved Domains (5) summary

COG1196
Location:180 → 470

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd08808
Location:75 → 160

CARD_CARD11_CARMA1; Caspase activation and recruitment domain of CARD11-like proteins

cl00117
Location:767 → 819

PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...

cl17036
Location:860 → 909

SH3; Src Homology 3 domain superfamily

cl17190
Location:1076 → 1210

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
XM_040647348.2 → XP_040503282.1 caspase recruitment domain-containing protein 11 isoform X3

UniProtKB/TrEMBL

Q5F3W0

Conserved Domains (5) summary

COG1196
Location:120 → 410

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd08808
Location:15 → 100

CARD_CARD11_CARMA1; Caspase activation and recruitment domain of CARD11-like proteins

cl00117
Location:707 → 759

PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...

cl17036
Location:800 → 849

SH3; Src Homology 3 domain superfamily

cl17190
Location:1016 → 1150

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052586.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

3431639..3471796 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_046927348.1 → XP_046783304.1 caspase recruitment domain-containing protein 11 isoform X2

UniProtKB/TrEMBL

Q5F3W0
XM_046927347.1 → XP_046783303.1 caspase recruitment domain-containing protein 11 isoform X1

UniProtKB/TrEMBL

Q5F3W0
XM_046927349.1 → XP_046783305.1 caspase recruitment domain-containing protein 11 isoform X3

UniProtKB/TrEMBL

Q5F3W0