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    Gprasp1 G protein-coupled receptor associated sorting protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 67298, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Gprasp1provided by MGI
    Official Full Name
    G protein-coupled receptor associated sorting protein 1provided by MGI
    Primary source
    MGI:MGI:1917418
    See related
    Ensembl:ENSMUSG00000043384 AllianceGenome:MGI:1917418
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GASP; GASP1; 2210415K24Rik; 3110031O14Rik
    Summary
    Predicted to be involved in G protein-coupled receptor catabolic process and endosome to lysosome transport. Predicted to be active in cytosol and nucleus. Is expressed in brain. Orthologous to human GPRASP1 (G protein-coupled receptor associated sorting protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in CNS E18 (RPKM 73.7), CNS E14 (RPKM 50.7) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gprasp1 in Genome Data Viewer
    Location:
    X F1; X 57.26 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (134643441..134704217)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (135742692..135803468)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene t-complex 11 family, X-linked 2 Neighboring gene STARR-seq mESC enhancer starr_47970 Neighboring gene thymosin beta 15a Neighboring gene microRNA 7646 Neighboring gene armadillo repeat containing, X-linked 5 Neighboring gene RAB18, member RAS oncogene family pseudogene Neighboring gene microRNA 1970 Neighboring gene STARR-seq mESC enhancer starr_47971 Neighboring gene G protein-coupled receptor associated sorting protein 2 Neighboring gene STARR-seq mESC enhancer starr_47972 Neighboring gene basic helix-loop-helix domain containing, class B9 Neighboring gene predicted gene, 31214

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Arrestin-3 Agonism at Dopamine D(3) Receptors Defines a Subclass of Second-Generation Antipsychotics That Promotes Drug Tolerance. Schamiloglu S, et al. Biol Psychiatry, 2023 Oct 1. PMID 36931452, Free PMC Article
    2. Attenuated behavioural responses to acute and chronic cocaine in GASP-1-deficient mice. Boeuf J, et al. Eur J Neurosci, 2009 Sep. PMID 19712096
    3. Impaired striatum-dependent behavior in GASP-1-knock-out mice. Mathis C, et al. Genes Brain Behav, 2011 Apr. PMID 21091868
    4. GPRASP1 loss-of-function links to arteriovenous malformations by endothelial activating GPR4 signals. Li R, et al. Brain, 2024 Apr 4. PMID 37787182
    5. Ubiquitous Gasp1 overexpression in mice leads mainly to a hypermuscular phenotype. Monestier O, et al. BMC Genomics, 2012 Oct 10. PMID 23046573, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GPRASP1 loss-of-function links to arteriovenous malformations by endothelial activating GPR4 signals.
      Title: GPRASP1 loss-of-function links to arteriovenous malformations by endothelial activating GPR4 signals.
    2. GPRASP proteins are critical negative regulators of hematopoietic stem cell transplantation.
      Title: GPRASP proteins are critical negative regulators of hematopoietic stem cell transplantation.
    3. present the First low resolution solution structure of myostatin-free and myostatin-bound states of GASP-1 and GASP-2
      Title: Alternative binding modes identified for growth and differentiation factor-associated serum protein (GASP) family antagonism of myostatin.
    4. Gasp-1 overexpression resulted in increased myostatin expression.
      Title: Absence of hyperplasia in Gasp-1 overexpressing mice is dependent on myostatin up-regulation.
    5. GASP-1 and GASP-2 are important modulators of GDF-11 and MSTN activity in vivo.
      Title: Regulation of GDF-11 and myostatin activity by GASP-1 and GASP-2.
    6. Overexpression of Gasp1 led to an increase in muscle mass observed not before day 15 of postnatal life.
      Title: Ubiquitous Gasp1 overexpression in mice leads mainly to a hypermuscular phenotype.
    7. The pattern of behavioral deficits observed in GASP-1-deficient mice is coherent with current knowledge of the role of striatal G protein-coupled receptor(GPCR)s in acquisition/expression of skilled behavior and motivation.
      Title: Impaired striatum-dependent behavior in GASP-1-knock-out mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (4)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC100209

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in G protein-coupled receptor catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in G protein-coupled receptor catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in endosome to lysosome transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endosome to lysosome transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    G-protein coupled receptor-associated sorting protein 1
    Names
    GASP-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004359.2 → NP_001004359.1  G-protein coupled receptor-associated sorting protein 1

      See identical proteins and their annotated locations for NP_001004359.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AB093241, BB619497, BC027187, BC070413, BY099746
      Consensus CDS
      CCDS30409.1
      UniProtKB/Swiss-Prot
      A2AGB6, Q5U4C1, Q8BKR8, Q8BUN4, Q8BYK9, Q8CHF4, Q8R095
      Conserved Domains (1) summary
      pfam04826
      Location:1117 → 1303
      Arm_2; Armadillo-like

    2. NM_001005385.1 → NP_001005385.1  G-protein coupled receptor-associated sorting protein 1

      See identical proteins and their annotated locations for NP_001005385.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AB093241, AK083192, BB619497, BC027187, BC070413
      Consensus CDS
      CCDS30409.1
      UniProtKB/Swiss-Prot
      A2AGB6, Q5U4C1, Q8BKR8, Q8BUN4, Q8BYK9, Q8CHF4, Q8R095
      Related
      ENSMUSP00000108770.2, ENSMUST00000113145.8
      Conserved Domains (1) summary
      pfam04826
      Location:1117 → 1303
      Arm_2; Armadillo-like

    3. NM_026081.5 → NP_080357.4  G-protein coupled receptor-associated sorting protein 1

      See identical proteins and their annotated locations for NP_080357.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      BB619497, BC058970, BC070413
      Consensus CDS
      CCDS30409.1
      UniProtKB/Swiss-Prot
      A2AGB6, Q5U4C1, Q8BKR8, Q8BUN4, Q8BYK9, Q8CHF4, Q8R095
      Related
      ENSMUSP00000108769.2, ENSMUST00000113144.8
      Conserved Domains (1) summary
      pfam04826
      Location:1117 → 1303
      Arm_2; Armadillo-like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      134643441..134704217
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U4C1.1 GenPept UniProtKB/Swiss-Prot:Q5U4C1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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