LIG4 DNA ligase 4 [Homo sapiens (human)] - Gene

Summary

Official Symbol: LIG4provided by HGNC
Official Full Name: DNA ligase 4provided by HGNC
Primary source: HGNC:HGNC:6601
See related: Ensembl:ENSG00000174405 MIM:601837; AllianceGenome:HGNC:6601
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: LIG4S
Summary: The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in brain (RPKM 5.8), testis (RPKM 4.8) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 13q33.3

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	13	NC_000013.11 (108207442..108218349, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	13	NC_060937.1 (107433544..107444540, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	13	NC_000013.10 (108859790..108870697, complement)

Chromosome 13 - NC_000013.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Critical residues in the Ku70 von Willebrand A domain mediate Ku interaction with the LigIV-XRCC4 complex in non-homologous end-joining.
Title: Critical residues in the Ku70 von Willebrand A domain mediate Ku interaction with the LigIV-XRCC4 complex in non-homologous end-joining.
Expanding the phenotypic spectrum of LIG4 pathogenic variations: neuro-histopathological description of 4 fetuses with stenosis of the aqueduct.
Title: Expanding the phenotypic spectrum of LIG4 pathogenic variations: neuro-histopathological description of 4 fetuses with stenosis of the aqueduct.
Deficiency of ligase IV leads to reduced NHEJ, accumulation of DNA damage, and can sensitize cells to cancer therapeutics.
Title: Deficiency of ligase IV leads to reduced NHEJ, accumulation of DNA damage, and can sensitize cells to cancer therapeutics.
The Contribution of DNA Ligase 4 Polymorphisms to Colorectal Cancer.
Title: The Contribution of DNA Ligase 4 Polymorphisms to Colorectal Cancer.
Autoimmunity and immunodeficiency associated with monoallelic LIG4 mutations via haploinsufficiency.
Title: Autoimmunity and immunodeficiency associated with monoallelic LIG4 mutations via haploinsufficiency.
The Contribution of DNA Ligase 4 Genetic Variations to Taiwanese Lung Cancer.
Title: The Contribution of DNA Ligase 4 Genetic Variations to Taiwanese Lung Cancer.
[Correlation of polymorphisms of DNA double-strand break repair genes XRCC5, LIG4 and glioma].
Title: [Correlation of polymorphisms of DNA double-strand break repair genes XRCC5, LIG4 and glioma].
USP39 promotes non-homologous end-joining repair by poly(ADP-ribose)-induced liquid demixing.
Title: USP39 promotes non-homologous end-joining repair by poly(ADP-ribose)-induced liquid demixing.
Characterization of a Cohort of Patients With LIG4 Deficiency Reveals the Founder Effect of p.R278L, Unique to the Chinese Population.
Title: Characterization of a Cohort of Patients With LIG4 Deficiency Reveals the Founder Effect of p.R278L, Unique to the Chinese Population.
Hypomorphic mutations in human DNA ligase IV lead to compromised DNA binding efficiency, hydrophobicity and thermal stability.
Title: Hypomorphic mutations in human DNA ligase IV lead to compromised DNA binding efficiency, hydrophobicity and thermal stability.

Submit: New GeneRIF Correction See all GeneRIFs (106)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
DNA ligase IV deficiency MedGen: C1847827 OMIM: 606593 GeneReviews: Not available	not available
Multiple myeloma MedGen: C0026764 OMIM: 254500 GeneReviews: Not available	not available

EBI GWAS Catalog

Description
Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

LIG4 (e-PCR)
- UniSTS:505382

G67234 (e-PCR)
- UniSTS:186438

SGC35475 (e-PCR)
- UniSTS:70806

RH98317 (e-PCR)
- UniSTS:85669

LIG4_354 (e-PCR)
- UniSTS:277452

D13S1452 (e-PCR)
- UniSTS:60382

D13S870E (e-PCR)
- UniSTS:151532

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IBA Inferred from Biological aspect of Ancestor more info
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA ligase (ATP) activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA ligase (ATP) activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA ligase (ATP) activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA ligase activity	TAS Traceable Author Statement more info
enables ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables magnesium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DN2 thymocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in DNA biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in DNA ligation	IDA Inferred from Direct Assay more info	PubMed
involved_in DNA ligation involved in DNA recombination	ISS Inferred from Sequence or Structural Similarity more info
involved_in DNA ligation involved in DNA repair	IDA Inferred from Direct Assay more info	PubMed
involved_in DNA ligation involved in DNA repair	ISS Inferred from Sequence or Structural Similarity more info
involved_in T cell differentiation in thymus	ISS Inferred from Sequence or Structural Similarity more info
involved_in T cell receptor V(D)J recombination	ISS Inferred from Sequence or Structural Similarity more info
involved_in V(D)J recombination	IDA Inferred from Direct Assay more info	PubMed
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to ionizing radiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to lithium ion	IEA Inferred from Electronic Annotation more info
involved_in central nervous system development	ISS Inferred from Sequence or Structural Similarity more info
involved_in chromosome organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in double-strand break repair	IDA Inferred from Direct Assay more info	PubMed
involved_in double-strand break repair	ISS Inferred from Sequence or Structural Similarity more info
involved_in double-strand break repair via classical nonhomologous end joining	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in double-strand break repair via nonhomologous end joining	IBA Inferred from Biological aspect of Ancestor more info
involved_in double-strand break repair via nonhomologous end joining	IDA Inferred from Direct Assay more info	PubMed
involved_in double-strand break repair via nonhomologous end joining	IGI Inferred from Genetic Interaction more info	PubMed
involved_in double-strand break repair via nonhomologous end joining	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in double-strand break repair via nonhomologous end joining	TAS Traceable Author Statement more info
involved_in establishment of integrated proviral latency	TAS Traceable Author Statement more info
involved_in fibroblast proliferation	IEA Inferred from Electronic Annotation more info
involved_in immunoglobulin V(D)J recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in in utero embryonic development	ISS Inferred from Sequence or Structural Similarity more info
involved_in isotype switching	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of neuron apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in neurogenesis	IEA Inferred from Electronic Annotation more info
involved_in neuron apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in nucleotide-excision repair, DNA gap filling	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleotide-excision repair, DNA gap filling	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of chromosome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of fibroblast proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of neurogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in pro-B cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to X-ray	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to gamma radiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in single strand break repair	IDA Inferred from Direct Assay more info	PubMed
involved_in somatic stem cell population maintenance	ISS Inferred from Sequence or Structural Similarity more info
involved_in stem cell proliferation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of DNA ligase IV complex	IBA Inferred from Biological aspect of Ancestor more info
part_of DNA ligase IV complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of DNA-dependent protein kinase-DNA ligase 4 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of DNA-dependent protein kinase-DNA ligase 4 complex	IDA Inferred from Direct Assay more info	PubMed
part_of DNA-dependent protein kinase-DNA ligase 4 complex	ISS Inferred from Sequence or Structural Similarity more info
located_in chromosome, telomeric region	IC Inferred by Curator more info	PubMed
located_in condensed chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
part_of nonhomologous end joining complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: DNA ligase 4

Names: DNA joinase; DNA ligase IV; DNA repair enzyme; ligase IV, DNA, ATP-dependent; polydeoxyribonucleotide synthase [ATP] 4; polynucleotide ligase; sealase

NP_001091738.1

EC 6.5.1.1

NP_001317524.1

EC 6.5.1.1

NP_001339527.1

EC 6.5.1.1

NP_001339528.1

EC 6.5.1.1

NP_001339529.1

EC 6.5.1.1

NP_001339530.1

EC 6.5.1.1

NP_001339531.1

EC 6.5.1.1

NP_001339532.1

EC 6.5.1.1

NP_001339533.1

EC 6.5.1.1

NP_001366024.1

EC 6.5.1.1

NP_002303.2

EC 6.5.1.1

NP_996820.1

EC 6.5.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_007396.1 RefSeqGene

Range

2167..13093

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_79

mRNA and Protein(s)

NM_001098268.2 → NP_001091738.1 DNA ligase 4 isoform 1

See identical proteins and their annotated locations for NP_001091738.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-3 and 5-10 all encode the same isoform (1).

Source sequence(s)

BC037491, BX648833

Consensus CDS

CCDS9508.1

UniProtKB/Swiss-Prot

P49917, Q8IY66, Q8TEU5

UniProtKB/TrEMBL

B2RBW4

Related

ENSP00000385955.1, ENST00000405925.2

Conserved Domains (4) summary

TIGR00574
Location:81 → 602

dnl1; DNA ligase I, ATP-dependent (dnl1)

cd17717
Location:813 → 900

BRCT_DNA_ligase_IV_rpt2; second BRCT domain of DNA ligase 4 (LIG4) and similar proteins

cd17722
Location:658 → 745

BRCT_DNA_ligase_IV_rpt1; first BRCT domain of DNA ligase 4 (LIG4) and similar proteins

pfam11411
Location:750 → 783

DNA_ligase_IV; DNA ligase IV
NM_001330595.2 → NP_001317524.1 DNA ligase 4 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a dowstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.

Source sequence(s)

AK292419, AL157762, BC037491, BX648833, DC372305

Consensus CDS

CCDS81779.1

UniProtKB/TrEMBL

A0A0C4DGV9, A8K8Q4

Related

ENSP00000480814.1, ENST00000614526.2
NM_001352598.2 → NP_001339527.1 DNA ligase 4 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (5), as well as variants 1-3 and 6-10, encodes isoform 1.

Source sequence(s)

AL157762

Consensus CDS

CCDS9508.1

UniProtKB/Swiss-Prot

P49917, Q8IY66, Q8TEU5

UniProtKB/TrEMBL

B2RBW4

Related

ENSP00000509502.1, ENST00000688595.1

Conserved Domains (4) summary

TIGR00574
Location:81 → 602

dnl1; DNA ligase I, ATP-dependent (dnl1)

cd17717
Location:813 → 900

BRCT_DNA_ligase_IV_rpt2; second BRCT domain of DNA ligase 4 (LIG4) and similar proteins

cd17722
Location:658 → 745

BRCT_DNA_ligase_IV_rpt1; first BRCT domain of DNA ligase 4 (LIG4) and similar proteins

pfam11411
Location:750 → 783

DNA_ligase_IV; DNA ligase IV
NM_001352599.2 → NP_001339528.1 DNA ligase 4 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (6), as well as variants 1-3, 5, and 7-10, encodes isoform 1.

Source sequence(s)

AL157762

Consensus CDS

CCDS9508.1

UniProtKB/Swiss-Prot

P49917, Q8IY66, Q8TEU5

UniProtKB/TrEMBL

B2RBW4

Related

ENSP00000509564.1, ENST00000688396.1

Conserved Domains (4) summary

TIGR00574
Location:81 → 602

dnl1; DNA ligase I, ATP-dependent (dnl1)

cd17717
Location:813 → 900

BRCT_DNA_ligase_IV_rpt2; second BRCT domain of DNA ligase 4 (LIG4) and similar proteins

cd17722
Location:658 → 745

BRCT_DNA_ligase_IV_rpt1; first BRCT domain of DNA ligase 4 (LIG4) and similar proteins

pfam11411
Location:750 → 783

DNA_ligase_IV; DNA ligase IV
NM_001352600.2 → NP_001339529.1 DNA ligase 4 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (7), as well as variants 1-3, 5, 6, and 8-10, encodes isoform 1.

Source sequence(s)

AL157762

Consensus CDS

CCDS9508.1

UniProtKB/Swiss-Prot

P49917, Q8IY66, Q8TEU5

UniProtKB/TrEMBL

B2RBW4

Related

ENSP00000509304.1, ENST00000688455.1

Conserved Domains (4) summary

TIGR00574
Location:81 → 602

dnl1; DNA ligase I, ATP-dependent (dnl1)

cd17717
Location:813 → 900

BRCT_DNA_ligase_IV_rpt2; second BRCT domain of DNA ligase 4 (LIG4) and similar proteins

cd17722
Location:658 → 745

BRCT_DNA_ligase_IV_rpt1; first BRCT domain of DNA ligase 4 (LIG4) and similar proteins

pfam11411
Location:750 → 783

DNA_ligase_IV; DNA ligase IV
NM_001352601.2 → NP_001339530.1 DNA ligase 4 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (8), as well as variants 1-3, 5-7, 9, and 10, encodes isoform 1.

Source sequence(s)

AL157762

Consensus CDS

CCDS9508.1

UniProtKB/Swiss-Prot

P49917, Q8IY66, Q8TEU5

UniProtKB/TrEMBL

B2RBW4

Related

ENSP00000509906.1, ENST00000688529.1

Conserved Domains (4) summary

TIGR00574
Location:81 → 602

dnl1; DNA ligase I, ATP-dependent (dnl1)

cd17717
Location:813 → 900

BRCT_DNA_ligase_IV_rpt2; second BRCT domain of DNA ligase 4 (LIG4) and similar proteins

cd17722
Location:658 → 745

BRCT_DNA_ligase_IV_rpt1; first BRCT domain of DNA ligase 4 (LIG4) and similar proteins

pfam11411
Location:750 → 783

DNA_ligase_IV; DNA ligase IV
NM_001352602.2 → NP_001339531.1 DNA ligase 4 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (9), as well as variants 1-3, 5-8, and 10, encodes isoform 1.

Source sequence(s)

AL157762

Consensus CDS

CCDS9508.1

UniProtKB/Swiss-Prot

P49917, Q8IY66, Q8TEU5

UniProtKB/TrEMBL

B2RBW4

Related

ENSP00000508512.1, ENST00000687164.1

Conserved Domains (4) summary

TIGR00574
Location:81 → 602

dnl1; DNA ligase I, ATP-dependent (dnl1)

cd17717
Location:813 → 900

BRCT_DNA_ligase_IV_rpt2; second BRCT domain of DNA ligase 4 (LIG4) and similar proteins

cd17722
Location:658 → 745

BRCT_DNA_ligase_IV_rpt1; first BRCT domain of DNA ligase 4 (LIG4) and similar proteins

pfam11411
Location:750 → 783

DNA_ligase_IV; DNA ligase IV
NM_001352603.1 → NP_001339532.1 DNA ligase 4 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (10), as well as variants 1-3 and 5-9, encodes isoform 1.

Source sequence(s)

AL157762

Consensus CDS

CCDS9508.1

UniProtKB/Swiss-Prot

P49917, Q8IY66, Q8TEU5

UniProtKB/TrEMBL

B2RBW4

Conserved Domains (4) summary

TIGR00574
Location:81 → 602

dnl1; DNA ligase I, ATP-dependent (dnl1)

cd17717
Location:813 → 900

BRCT_DNA_ligase_IV_rpt2; second BRCT domain of DNA ligase 4 (LIG4) and similar proteins

cd17722
Location:658 → 745

BRCT_DNA_ligase_IV_rpt1; first BRCT domain of DNA ligase 4 (LIG4) and similar proteins

pfam11411
Location:750 → 783

DNA_ligase_IV; DNA ligase IV
NM_001352604.2 → NP_001339533.1 DNA ligase 4 isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (11) encodes the longest isoform (3).

Source sequence(s)

AL157762

UniProtKB/TrEMBL

B2RBW4

Conserved Domains (3) summary

TIGR00574
Location:93 → 614

dnl1; DNA ligase I, ATP-dependent (dnl1)

pfam00533
Location:668 → 742

BRCT; BRCA1 C Terminus (BRCT) domain

pfam11411
Location:762 → 795

DNA_ligase_IV; DNA ligase IV
NM_001379095.1 → NP_001366024.1 DNA ligase 4 isoform 1

Status: REVIEWED

Source sequence(s)

AL157762, DA211056

Consensus CDS

CCDS9508.1

UniProtKB/Swiss-Prot

P49917, Q8IY66, Q8TEU5

UniProtKB/TrEMBL

B2RBW4

Related

ENSP00000484288.1, ENST00000611712.4

Conserved Domains (4) summary

TIGR00574
Location:81 → 602

dnl1; DNA ligase I, ATP-dependent (dnl1)

cd17717
Location:813 → 900

BRCT_DNA_ligase_IV_rpt2; second BRCT domain of DNA ligase 4 (LIG4) and similar proteins

cd17722
Location:658 → 745

BRCT_DNA_ligase_IV_rpt1; first BRCT domain of DNA ligase 4 (LIG4) and similar proteins

pfam11411
Location:750 → 783

DNA_ligase_IV; DNA ligase IV
NM_002312.3 → NP_002303.2 DNA ligase 4 isoform 1

See identical proteins and their annotated locations for NP_002303.2

Status: REVIEWED

Description

Transcript Variant: This variant (1), as well as variants 2, 3, and 5-10, encodes isoform 1.

Source sequence(s)

AI809944, BC037491, CD102896, X83441

Consensus CDS

CCDS9508.1

UniProtKB/Swiss-Prot

P49917, Q8IY66, Q8TEU5

UniProtKB/TrEMBL

B2RBW4

Conserved Domains (4) summary

TIGR00574
Location:81 → 602

dnl1; DNA ligase I, ATP-dependent (dnl1)

cd17717
Location:813 → 900

BRCT_DNA_ligase_IV_rpt2; second BRCT domain of DNA ligase 4 (LIG4) and similar proteins

cd17722
Location:658 → 745

BRCT_DNA_ligase_IV_rpt1; first BRCT domain of DNA ligase 4 (LIG4) and similar proteins

pfam11411
Location:750 → 783

DNA_ligase_IV; DNA ligase IV
NM_206937.2 → NP_996820.1 DNA ligase 4 isoform 1

See identical proteins and their annotated locations for NP_996820.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-3 and 5-10 all encode the same isoform (1).

Source sequence(s)

AL157762, BC037491, BX648833

Consensus CDS

CCDS9508.1

UniProtKB/Swiss-Prot

P49917, Q8IY66, Q8TEU5

UniProtKB/TrEMBL

B2RBW4

Related

ENSP00000402030.1, ENST00000442234.6

Conserved Domains (4) summary

TIGR00574
Location:81 → 602

dnl1; DNA ligase I, ATP-dependent (dnl1)

cd17717
Location:813 → 900

BRCT_DNA_ligase_IV_rpt2; second BRCT domain of DNA ligase 4 (LIG4) and similar proteins

cd17722
Location:658 → 745

BRCT_DNA_ligase_IV_rpt1; first BRCT domain of DNA ligase 4 (LIG4) and similar proteins

pfam11411
Location:750 → 783

DNA_ligase_IV; DNA ligase IV