TUSC8 tumor suppressor candidate 8 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TUSC8provided by HGNC
Official Full Name: tumor suppressor candidate 8provided by HGNC
Primary source: HGNC:HGNC:49111
See related: AllianceGenome:HGNC:49111
Gene type: ncRNA
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: LINC01071; XLOC_010588
Summary: Enables miRNA inhibitor activity via base-pairing. Involved in lncRNA-mediated post-transcriptional gene silencing. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in prostate (RPKM 1.7), salivary gland (RPKM 1.7) and 7 other tissues See more
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Genomic context

Location:: 13q14.11

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	13	NC_000013.11 (44400250..44405984, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	13	NC_060937.1 (43620022..43625746, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	13	NC_000013.10 (44974386..44980120, complement)

Chromosome 13 - NC_000013.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TUSC8 enhances cisplatin sensitivity of NSCLC cells through regulating VEGFA.
Title: TUSC8 enhances cisplatin sensitivity of NSCLC cells through regulating VEGFA.
TUSC8 inhibits the development of osteosarcoma by sponging miR1973p and targeting EHD2.
Title: TUSC8 inhibits the development of osteosarcoma by sponging miR‑197‑3p and targeting EHD2.
These results demonstrated that overexpression of TUSC8 could inhibit the invasion and migration of cervical cancer cells by upregulating PTEN via miR-641.
Title: LncRNA TUSC8 inhibits the invasion and migration of cervical cancer cells via miR-641/PTEN axis.
Results suggested that XLOC_010588 plays a pivotal role in cervical cancer cell proliferation via decreasing c-Myc expression.
Title: Low expression of long noncoding XLOC_010588 indicates a poor prognosis and promotes proliferation through upregulation of c-Myc in cervical cancer.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See studies and variants in dbVar

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General gene information

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Other Names

long intergenic non-protein coding RNA 1071
tumor suppressor candidate 8 (non-protein coding)

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables miRNA inhibitor activity via base-pairing	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in lncRNA-mediated post-transcriptional gene silencing	IDA Inferred from Direct Assay more info	PubMed

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.