Dpp6 dipeptidylpeptidase 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dpp6provided by MGI
Official Full Name: dipeptidylpeptidase 6provided by MGI
Primary source: MGI:MGI:94921
See related: Ensembl:ENSMUSG00000061576 AllianceGenome:MGI:94921
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rw; Dpp-6; Peplb; D5Buc3; D5Buc4; D5Buc5; DPP VI; Gm1377; In(5)6H-p; B930011P16Rik
Summary: Enables potassium channel regulator activity. Involved in protein localization to plasma membrane; regulation of postsynaptic membrane potential; and regulation of potassium ion transmembrane transport. Acts upstream of or within neuronal action potential and positive regulation of potassium ion transmembrane transport. Located in plasma membrane. Part of voltage-gated potassium channel complex. Is active in synapse. Is expressed in several structures, including 1st branchial arch; alimentary system; central nervous system; intervertebral disc; and nose. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; autosomal dominant intellectual developmental disorder 33; and spinal muscular atrophy. Orthologous to human DPP6 (dipeptidyl peptidase like 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in cerebellum adult (RPKM 32.7), frontal lobe adult (RPKM 23.3) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 B1; 5 12.92 cM

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (27022355..27932498)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (26817357..27727500)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Alzheimer's disease/dementia-associated brain pathology in aging DPP6-KO mice.
Title: Alzheimer's disease/dementia-associated brain pathology in aging DPP6-KO mice.
expression pattern of DPP6 suggests that it may be involved in mandible and tooth development.
Title: Expression of DPP6 in Meckel's cartilage and tooth germs during mouse facial development.
Dipeptidyl-peptidase 6 has an unexpected but important role in cell adhesion and motility, impacting the hippocampal synaptic development and function.
Title: DPP6 regulation of dendritic morphogenesis impacts hippocampal synaptic development.
WT PrP(C), in a DPP6-dependent manner, modulated Kv4.2 channel properties, causing an increase in peak amplitude
Title: The prion protein modulates A-type K+ currents mediated by Kv4.2 complexes through dipeptidyl aminopeptidase-like protein 6.
Findings of this study indicate that an altered response of Kv4/DPP6 to long-term neuroleptic administration is involved in neuroleptic-induced TD.
Title: DPP6 as a candidate gene for neuroleptic-induced tardive dyskinesia.
DPP6 co-expression with TASK-3 results in the formation of a protein complex that enhances resting membrane potassium conductance.
Title: A new TASK for Dipeptidyl Peptidase-like Protein 6.
the present study described epigenetic silencing of Dpp6 expression by DNA methylation and established that its ectopic expression can act as negative signal during RA induced neuronal differentiation of P19 cells.
Title: Epigenetic regulation of Dpp6 expression by Dnmt3b and its novel role in the inhibition of RA induced neuronal differentiation of P19 cells.
In the presence of DPP6 or DPP10, cell surface Kv4.2 protein expression is selectively increased.
Title: Augmentation of Kv4.2-encoded currents by accessory dipeptidyl peptidase 6 and 10 subunits reflects selective cell surface Kv4.2 protein stabilization.
The expression pattern of Dpp6 suggests that Dpp6 may be involved in embryonic craniofacial development.
Title: Expression of Dpp6 in mouse embryonic craniofacial development.
The DPP6-E is selectively expressed in a few neuronal populations in brain including cerebellar granule neurons, hippocampal pyramidal cells and neurons in intermediary layers of the superior colliculus.
Title: A novel DPP6 isoform (DPP6-E) can account for differences between neuronal and reconstituted A-type K(+) channels.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D5Jcs89 (e-PCR), detects polymorphism
- UniSTS:507911

13.MMHAP6FLE1.seq (e-PCR)
- UniSTS:123182

Dpp6 (e-PCR), detects polymorphism
- UniSTS:166210

D5Mit251 (e-PCR), detects polymorphism
- UniSTS:130386

32.MMHAP62FLC5.seq (e-PCR)
- UniSTS:123992

MHAa75f2.seq (e-PCR)
- UniSTS:125312

D5Mit1004 (e-PCR), detects polymorphism
- UniSTS:142466

Dpp6 (e-PCR), detects polymorphism
- UniSTS:545926

D5Jcs73 (e-PCR), detects polymorphism
- UniSTS:478909

D5Jcs74 (e-PCR), detects polymorphism
- UniSTS:478910

Dpp6 (e-PCR), detects polymorphism
- UniSTS:548059

Dpp6 (e-PCR), detects polymorphism
- UniSTS:548060

D5Mit386 (e-PCR), detects polymorphism
- UniSTS:130536

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
NOT enables dipeptidyl-peptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables potassium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium channel regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables potassium channel regulator activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables serine-type peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuronal action potential	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of potassium ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of potassium ion transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of potassium ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of postsynaptic membrane potential	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic membrane potential	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of postsynaptic membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of potassium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of potassium ion transmembrane transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of potassium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	IDA Inferred from Direct Assay more info	PubMed
part_of voltage-gated potassium channel complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: A-type potassium channel modulatory protein DPP6

Names: DPPX; dipeptidyl aminopeptidase-like protein 6; dipeptidyl aminopeptidase-related protein; dipeptidyl peptidase IV-like protein; dipeptidyl peptidase VI; dipeptidylpeptidase VI; inversion, Chr 5, Harwell 6, proximal

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001136060.2 → NP_001129532.1 A-type potassium channel modulatory protein DPP6 isoform 1

See identical proteins and their annotated locations for NP_001129532.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) has an alternate upstream 5' exon, as compared to variant 3. The resulting isoform (1) is shorter and has a different N-terminus, as compared to isoform 3.

Source sequence(s)

AK031903, BC048383, BY127642

Consensus CDS

CCDS51447.1

UniProtKB/TrEMBL

Q3TY19, Q80VM5

Related

ENSMUSP00000099012.4, ENSMUST00000101471.4

Conserved Domains (2) summary

pfam00930
Location:133 → 499

DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

cl21494
Location:583 → 785

Abhydrolase; alpha/beta hydrolases
NM_001198886.1 → NP_001185815.1 A-type potassium channel modulatory protein DPP6 isoform 4

See identical proteins and their annotated locations for NP_001185815.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) has an alternate upstream 5' exon, as compared to variant 3. The resulting isoform (4) is shorter and has a different N-terminus, as compared to isoform 3.

Source sequence(s)

AK031903, BC085154

Consensus CDS

CCDS57332.1

UniProtKB/TrEMBL

Q3TY19, Q5U4C2

Related

ENSMUSP00000113849.2, ENSMUST00000120555.8

Conserved Domains (2) summary

pfam00930
Location:131 → 497

DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

cl21494
Location:581 → 783

Abhydrolase; alpha/beta hydrolases
NM_010075.2 → NP_034205.1 A-type potassium channel modulatory protein DPP6 isoform 2

See identical proteins and their annotated locations for NP_034205.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) has an alternate upstream 5' exon, as compared to variant 3. The resulting isoform (2) is shorter and has a different N-terminus, as compared to isoform 3.

Source sequence(s)

AF092507, AK031903

Consensus CDS

CCDS19139.1

UniProtKB/Swiss-Prot

Q9QWW2, Q9Z218, Q9Z219

UniProtKB/TrEMBL

Q3TY19

Related

ENSMUSP00000071435.7, ENSMUST00000071500.13

Conserved Domains (2) summary

pfam00930
Location:134 → 500

DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

cl21494
Location:584 → 786

Abhydrolase; alpha/beta hydrolases
NM_207282.3 → NP_997165.2 A-type potassium channel modulatory protein DPP6 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) encodes the longest isoform (3).

Source sequence(s)

AF092507, AK031903, AK158964, BY280444

Consensus CDS

CCDS51446.1

UniProtKB/TrEMBL

E9PWX1, Q3TY19

Related

ENSMUSP00000113441.2, ENSMUST00000122171.8

Conserved Domains (2) summary

pfam00930
Location:189 → 555

DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

cl21494
Location:639 → 841

Abhydrolase; alpha/beta hydrolases