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    Cnnm2 cyclin and CBS domain divalent metal cation transport mediator 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294014, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cnnm2provided by RGD
    Official Full Name
    cyclin and CBS domain divalent metal cation transport mediator 2provided by RGD
    Primary source
    RGD:1308162
    See related
    EnsemblRapid:ENSRNOG00000020113 AllianceGenome:RGD:1308162
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ATP binding activity and magnesium ion transmembrane transporter activity. Predicted to be involved in magnesium ion homeostasis. Predicted to act upstream of or within magnesium ion transport. Predicted to be located in basolateral plasma membrane. Predicted to be active in glutamatergic synapse and plasma membrane. Human ortholog(s) of this gene implicated in renal hypomagnesemia 6. Orthologous to human CNNM2 (cyclin and CBS domain divalent metal cation transport mediator 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 118.1), Brain (RPKM 58.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cnnm2 in Genome Data Viewer
    Location:
    1q54
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (255585063..255709455)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (245643682..245769542)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (266530421..266651292)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene arsenite methyltransferase Neighboring gene uncharacterized LOC134484091 Neighboring gene 5'-nucleotidase, cytosolic II Neighboring gene uncharacterized LOC134484086 Neighboring gene transfer RNA arginine (anticodon UCU) 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mg2+-dependent interactions of ATP with the cystathionine-β-synthase (CBS) domains of a magnesium transporter. Hirata Y, et al. J Biol Chem, 2014 May 23. PMID 24706765, Free PMC Article
    2. CNNM2, encoding a basolateral protein required for renal Mg2+ handling, is mutated in dominant hypomagnesemia. Stuiver M, et al. Am J Hum Genet, 2011 Mar 11. PMID 21397062, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables magnesium ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in magnesium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in magnesium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within magnesium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in magnesium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within magnesium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    metal transporter CNNM2
    Names
    ancient conserved domain-containing protein 2
    cyclin-M2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001011942.1 → NP_001011942.1  metal transporter CNNM2

      See identical proteins and their annotated locations for NP_001011942.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085930
      UniProtKB/Swiss-Prot
      Q5U2P1
      Related
      ENSRNOP00000051583.2, ENSRNOT00000054699.4
      Conserved Domains (2) summary
      cd04590
      Location:470 → 575
      CBS_pair_CorC_HlyC_assoc; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in ...
      pfam01595
      Location:257 → 431
      DUF21; Domain of unknown function DUF21

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      255585063..255709455
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006231471.5 → XP_006231533.1  metal transporter CNNM2 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZZS9
      Conserved Domains (2) summary
      cd04590
      Location:470 → 575
      CBS_pair_CorC_HlyC_assoc; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in ...
      pfam01595
      Location:257 → 431
      DUF21; Domain of unknown function DUF21

    RNA

    1. XR_005504350.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U2P1.1 GenPept UniProtKB/Swiss-Prot:Q5U2P1

    Gene LinkOut

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