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    Cpa5 carboxypeptidase A5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 408212, updated on 9-Dec-2024

    Summary

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    Symbol
    Cpa5provided by RGD
    Full Name
    carboxypeptidase A5provided by RGD
    Primary source
    RGD:1303098
    See related
    EnsemblRapid:ENSRNOG00000010467 AllianceGenome:RGD:1303098
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Orthologous to human CPA5 (carboxypeptidase A5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 86.5) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cpa5 in Genome Data Viewer
    Location:
    4q22
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (60197123..60216883)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (59229754..59249503)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (57925334..57945069)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120102251 Neighboring gene carboxypeptidase A2 Neighboring gene carboxypeptidase A4 Neighboring gene uncharacterized LOC102553416 Neighboring gene carboxypeptidase A1 Neighboring gene centrosomal protein 41

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of three members of the human metallocarboxypeptidase gene family. Wei S, et al. J Biol Chem, 2002 Apr 26. PMID 11836249
    2. A genomic analysis of rat proteases and protease inhibitors. Puente XS, et al. Genome Res, 2004 Apr. PMID 15060002, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC94525

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metallocarboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    carboxypeptidase A5
    NP_001002808.2
    XP_006236278.1
    XP_006236279.1
    XP_006236280.1
    XP_038963901.1
    XP_038963903.1
    XP_063142482.1
    XP_063142483.1
    XP_063142484.1
    XP_063142485.1
    XP_063142486.1
    XP_063142487.1
    XP_063142488.1
    XP_063142489.1
    XP_063142490.1
    XP_063142491.1
    XP_063142492.1
    XP_063142493.1
    XP_063142494.1
    XP_063142495.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002808.2 → NP_001002808.2  carboxypeptidase A5

      See identical proteins and their annotated locations for NP_001002808.2

      Status: PROVISIONAL

      Source sequence(s)
      BC085840
      UniProtKB/TrEMBL
      E9PSV1, Q5U2W3, Q6IE16
      Conserved Domains (2) summary
      cd03870
      Location:134 → 434
      M14_CPA; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase A subgroup
      pfam02244
      Location:48 → 117
      Propep_M14; Carboxypeptidase activation peptide

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      60197123..60216883
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006236216.5 → XP_006236278.1  carboxypeptidase A5 isoform X2

      See identical proteins and their annotated locations for XP_006236278.1

      UniProtKB/TrEMBL
      E9PSV1, Q5U2W3, Q6IE16
      Related
      ENSRNOP00000013948.4, ENSRNOT00000013948.7
      Conserved Domains (2) summary
      cd03870
      Location:134 → 434
      M14_CPA; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase A subgroup
      pfam02244
      Location:48 → 117
      Propep_M14; Carboxypeptidase activation peptide

    2. XM_039107973.2 → XP_038963901.1  carboxypeptidase A5 isoform X4

      UniProtKB/TrEMBL
      Q6IE16
      Conserved Domains (2) summary
      pfam02244
      Location:48 → 117
      Propep_M14; Carboxypeptidase activation peptide
      cl11393
      Location:134 → 374
      Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins

    3. XM_006236217.5 → XP_006236279.1  carboxypeptidase A5 isoform X2

      See identical proteins and their annotated locations for XP_006236279.1

      UniProtKB/TrEMBL
      E9PSV1, Q5U2W3, Q6IE16
      Conserved Domains (2) summary
      cd03870
      Location:134 → 434
      M14_CPA; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase A subgroup
      pfam02244
      Location:48 → 117
      Propep_M14; Carboxypeptidase activation peptide

    4. XM_006236218.5 → XP_006236280.1  carboxypeptidase A5 isoform X2

      See identical proteins and their annotated locations for XP_006236280.1

      UniProtKB/TrEMBL
      E9PSV1, Q5U2W3, Q6IE16
      Conserved Domains (2) summary
      cd03870
      Location:134 → 434
      M14_CPA; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase A subgroup
      pfam02244
      Location:48 → 117
      Propep_M14; Carboxypeptidase activation peptide

    5. XM_063286422.1 → XP_063142492.1  carboxypeptidase A5 isoform X4

      UniProtKB/TrEMBL
      Q6IE16

    6. XM_063286412.1 → XP_063142482.1  carboxypeptidase A5 isoform X1

      UniProtKB/TrEMBL
      Q6IE16

    7. XM_063286415.1 → XP_063142485.1  carboxypeptidase A5 isoform X1

      UniProtKB/TrEMBL
      Q6IE16

    8. XM_039107975.2 → XP_038963903.1  carboxypeptidase A5 isoform X7

      Conserved Domains (2) summary
      pfam02244
      Location:48 → 117
      Propep_M14; Carboxypeptidase activation peptide
      cl11393
      Location:134 → 280
      Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins

    9. XM_063286419.1 → XP_063142489.1  carboxypeptidase A5 isoform X3

      UniProtKB/TrEMBL
      Q6IE16

    10. XM_063286418.1 → XP_063142488.1  carboxypeptidase A5 isoform X3

      UniProtKB/TrEMBL
      Q6IE16

    11. XM_063286413.1 → XP_063142483.1  carboxypeptidase A5 isoform X1

      UniProtKB/TrEMBL
      Q6IE16

    12. XM_063286420.1 → XP_063142490.1  carboxypeptidase A5 isoform X4

      UniProtKB/TrEMBL
      Q6IE16

    13. XM_063286416.1 → XP_063142486.1  carboxypeptidase A5 isoform X1

      UniProtKB/TrEMBL
      Q6IE16

    14. XM_063286417.1 → XP_063142487.1  carboxypeptidase A5 isoform X2

      UniProtKB/TrEMBL
      E9PSV1, Q5U2W3, Q6IE16

    15. XM_063286423.1 → XP_063142493.1  carboxypeptidase A5 isoform X5

    16. XM_063286421.1 → XP_063142491.1  carboxypeptidase A5 isoform X4

      UniProtKB/TrEMBL
      Q6IE16

    17. XM_063286414.1 → XP_063142484.1  carboxypeptidase A5 isoform X1

      UniProtKB/TrEMBL
      Q6IE16

    18. XM_063286425.1 → XP_063142495.1  carboxypeptidase A5 isoform X6

      UniProtKB/TrEMBL
      Q6IE16

    19. XM_063286424.1 → XP_063142494.1  carboxypeptidase A5 isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version

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