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    Tmem97 transmembrane protein 97 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303330, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmem97provided by RGD
    Official Full Name
    transmembrane protein 97provided by RGD
    Primary source
    RGD:1307423
    See related
    AllianceGenome:RGD:1307423
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1307423
    Summary
    Predicted to enable cholesterol binding activity and oxysterol binding activity. Predicted to be involved in several processes, including cholesterol homeostasis; positive regulation of lipoprotein transport; and regulation of intracellular cholesterol transport. Predicted to be located in several cellular components, including lysosome; nuclear membrane; and rough endoplasmic reticulum. Predicted to be active in endoplasmic reticulum. Orthologous to human TMEM97 (transmembrane protein 97). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 404.4), Liver (RPKM 260.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tmem97 in Genome Data Viewer
    Location:
    10q25
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (63936276..63945359, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (63438228..63447311, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (65811455..65820538, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene TNF alpha induced protein 1 Neighboring gene intraflagellar transport 20 Neighboring gene small nucleolar RNA SNORA70 Neighboring gene nemo like kinase Neighboring gene NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of cholesterol-regulating genes by targeted RNAi screening. Bartz F, et al. Cell Metab, 2009 Jul. PMID 19583955
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC105541

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cholesterol binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables oxysterol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxysterol binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cholesterol homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cholesterol homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of lipoprotein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of lipoprotein transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of wound healing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of wound healing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of intracellular cholesterol transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of intracellular cholesterol transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of intracellular lipid transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of intracellular lipid transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in rough endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in rough endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in rough endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sigma intracellular receptor 2
    Names
    sigma-2 receptor
    sigma2 receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008334.1 → NP_001008335.1  sigma intracellular receptor 2

      See identical proteins and their annotated locations for NP_001008335.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085344
      UniProtKB/Swiss-Prot
      Q5U3Y7
      UniProtKB/TrEMBL
      A6HH65
      Conserved Domains (1) summary
      pfam10914
      Location:12 → 150
      DUF2781; Protein of unknown function (DUF2781)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      63936276..63945359 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U3Y7.1 GenPept UniProtKB/Swiss-Prot:Q5U3Y7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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