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    Fblim1 filamin binding LIM protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362650, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fblim1provided by RGD
    Official Full Name
    filamin binding LIM protein 1provided by RGD
    Primary source
    RGD:1359551
    See related
    EnsemblRapid:ENSRNOG00000011774 AllianceGenome:RGD:1359551
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cal; Hnrnpl; hnRNP L
    Summary
    Predicted to enable filamin binding activity; pre-mRNA intronic binding activity; and transcription cis-regulatory region binding activity. Predicted to be involved in cell-cell adhesion; regulation of RNA metabolic process; and regulation of integrin activation. Predicted to be located in several cellular components, including chromatin; nuclear lumen; and ribonucleoprotein granule. Predicted to be part of ribonucleoprotein complex. Predicted to be active in focal adhesion and stress fiber. Orthologous to human FBLIM1 (filamin binding LIM protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 96.5), Lung (RPKM 33.4) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fblim1 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (159167004..159198578, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (153883945..153915524, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (160122466..160158921, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 17 Neighboring gene spen family transcriptional repressor Neighboring gene uncharacterized LOC134487029 Neighboring gene solute carrier family 25, member 34 Neighboring gene transmembrane protein 82

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Migfilin, a molecular switch in regulation of integrin activation. Ithychanda SS, et al. J Biol Chem, 2009 Feb 13. PMID 19074766, Free PMC Article
    2. A new member of the LIM protein family binds to filamin B and localizes at stress fibers. Takafuta T, et al. J Biol Chem, 2003 Apr 4. PMID 12496242
    3. Structural basis of the migfilin-filamin interaction and competition with integrin beta tails. Lad Y, et al. J Biol Chem, 2008 Dec 12. PMID 18829455, Free PMC Article
    4. Talins and kindlins: partners in integrin-mediated adhesion. Calderwood DA, et al. Nat Rev Mol Cell Biol, 2013 Aug. PMID 23860236, Free PMC Article
    5. Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Kuo JC, et al. Nat Cell Biol, 2011 Apr. PMID 21423176, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC105665

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables filamin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables filamin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pre-mRNA intronic binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables transcription cis-regulatory region binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of integrin activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell periphery ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromatin ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of ribonucleoprotein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in ribonucleoprotein granule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in stress fiber IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in stress fiber ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    heterogeneous nuclear ribonucleoprotein L
    Names
    CSX-associated LIM

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007554.2 → NP_001007555.1  heterogeneous nuclear ribonucleoprotein L isoform 2

      See identical proteins and their annotated locations for NP_001007555.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      F7FP13, Q5U1Y3
      Conserved Domains (2) summary
      cd09372
      Location:246 → 298
      LIM2_FBLP-1; The second LIM domain of the filamin-binding LIM protein-1 (FBLP-1)
      cl02475
      Location:181 → 239
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    2. NM_001399241.1 → NP_001386170.1  heterogeneous nuclear ribonucleoprotein L isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A0G2K995, A6ITU3, F7FP13
      Related
      ENSRNOP00000074912.1, ENSRNOT00000089345.3
      Conserved Domains (3) summary
      cd09357
      Location:306 → 367
      LIM3_Zyxin_like; The third LIM domain of Zyxin-like family
      cd09372
      Location:246 → 298
      LIM2_FBLP-1; The second LIM domain of the filamin-binding LIM protein-1 (FBLP-1)
      cl02475
      Location:181 → 239
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    3. NM_001399242.1 → NP_001386171.1  heterogeneous nuclear ribonucleoprotein L isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A0G2K995, A6ITU3, F7FP13
      Conserved Domains (3) summary
      cd09357
      Location:306 → 367
      LIM3_Zyxin_like; The third LIM domain of Zyxin-like family
      cd09372
      Location:246 → 298
      LIM2_FBLP-1; The second LIM domain of the filamin-binding LIM protein-1 (FBLP-1)
      cl02475
      Location:181 → 239
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      159167004..159198578 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008764276.4 → XP_008762498.1  heterogeneous nuclear ribonucleoprotein L isoform X4

      See identical proteins and their annotated locations for XP_008762498.1

      UniProtKB/TrEMBL
      A0A0G2K995, A6ITU3, F7FP13
      Conserved Domains (3) summary
      cd09357
      Location:306 → 367
      LIM3_Zyxin_like; The third LIM domain of Zyxin-like family
      cd09372
      Location:246 → 298
      LIM2_FBLP-1; The second LIM domain of the filamin-binding LIM protein-1 (FBLP-1)
      cl02475
      Location:181 → 239
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    2. XM_039110430.2 → XP_038966358.1  heterogeneous nuclear ribonucleoprotein L isoform X4

      UniProtKB/TrEMBL
      A0A0G2K995, A6ITU3, F7FP13
      Conserved Domains (3) summary
      cd09357
      Location:306 → 367
      LIM3_Zyxin_like; The third LIM domain of Zyxin-like family
      cd09372
      Location:246 → 298
      LIM2_FBLP-1; The second LIM domain of the filamin-binding LIM protein-1 (FBLP-1)
      cl02475
      Location:181 → 239
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    3. XM_039110429.2 → XP_038966357.1  heterogeneous nuclear ribonucleoprotein L isoform X4

      UniProtKB/TrEMBL
      A0A0G2K995, A6ITU3, F7FP13
      Conserved Domains (3) summary
      cd09357
      Location:306 → 367
      LIM3_Zyxin_like; The third LIM domain of Zyxin-like family
      cd09372
      Location:246 → 298
      LIM2_FBLP-1; The second LIM domain of the filamin-binding LIM protein-1 (FBLP-1)
      cl02475
      Location:181 → 239
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    4. XM_008764274.4 → XP_008762496.1  heterogeneous nuclear ribonucleoprotein L isoform X3

      UniProtKB/TrEMBL
      F7FP13
      Related
      ENSRNOP00000040868.4, ENSRNOT00000045237.5
      Conserved Domains (3) summary
      cd09357
      Location:317 → 378
      LIM3_Zyxin_like; The third LIM domain of Zyxin-like family
      cd09372
      Location:257 → 309
      LIM2_FBLP-1; The second LIM domain of the filamin-binding LIM protein-1 (FBLP-1)
      cl02475
      Location:192 → 250
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    5. XM_039110428.2 → XP_038966356.1  heterogeneous nuclear ribonucleoprotein L isoform X2

      UniProtKB/TrEMBL
      F7FP13
      Related
      ENSRNOP00000099565.1, ENSRNOT00000133282.1
      Conserved Domains (3) summary
      cd09357
      Location:393 → 454
      LIM3_Zyxin_like; The third LIM domain of Zyxin-like family
      cd09372
      Location:333 → 385
      LIM2_FBLP-1; The second LIM domain of the filamin-binding LIM protein-1 (FBLP-1)
      cl02475
      Location:268 → 326
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    6. XM_008764273.3 → XP_008762495.1  heterogeneous nuclear ribonucleoprotein L isoform X1

      Related
      ENSRNOP00000102131.1, ENSRNOT00000148404.1
      Conserved Domains (3) summary
      cd09357
      Location:482 → 543
      LIM3_Zyxin_like; The third LIM domain of Zyxin-like family
      cd09372
      Location:422 → 474
      LIM2_FBLP-1; The second LIM domain of the filamin-binding LIM protein-1 (FBLP-1)
      cl02475
      Location:357 → 415
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F1LQ48.2 GenPept UniProtKB/Swiss-Prot:F1LQ48

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