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    Mon1b MON1 homolog B, secretory traffciking associated [ Mus musculus (house mouse) ]

    Gene ID: 270096, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Mon1bprovided by MGI
    Official Full Name
    MON1 homolog B, secretory traffciking associatedprovided by MGI
    Primary source
    MGI:MGI:1923231
    See related
    Ensembl:ENSMUSG00000078908 AllianceGenome:MGI:1923231
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5031407H10; 5033413H12Rik
    Summary
    Predicted to be involved in early viral transcription and late viral transcription. Predicted to be located in cytoplasm. Predicted to be part of Mon1-Ccz1 complex. Orthologous to human MON1B (MON1 homolog B, secretory trafficking associated). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 6.2), adrenal adult (RPKM 5.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mon1b in Genome Data Viewer
    Location:
    8 E1; 8 59.65 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (114362218..114371824)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (113635586..113645192)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930571O06 gene Neighboring gene predicted gene, 24291 Neighboring gene STARR-seq mESC enhancer starr_22761 Neighboring gene collagen, type III, alpha 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_22762 Neighboring gene STARR-positive B cell enhancer ABC_E1771 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:116159691-116159874 Neighboring gene synaptonemal complex central element protein 1 like Neighboring gene predicted gene, 30052 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 18

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of two evolutionarily conserved genes regulating processing of engulfed apoptotic cells. Kinchen JM, et al. Nature, 2010 Apr 1. PMID 20305638, Free PMC Article
    2. A molecular profile of a hematopoietic stem cell niche. Hackney JA, et al. Proc Natl Acad Sci U S A, 2002 Oct 1. PMID 12226475, Free PMC Article
    3. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
    4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in early viral transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in early viral transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in late viral transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in late viral transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein targeting to vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Mon1-Ccz1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Mon1-Ccz1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Mon1-Ccz1 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    vacuolar fusion protein MON1 homolog B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001048143.2 → NP_001041608.1  vacuolar fusion protein MON1 homolog B

      See identical proteins and their annotated locations for NP_001041608.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC125463, BC062639, CJ089261
      Consensus CDS
      CCDS22685.1
      UniProtKB/Swiss-Prot
      Q69ZX1, Q6P5V5, Q8BMQ8
      Related
      ENSMUSP00000137605.2, ENSMUST00000179926.9
      Conserved Domains (1) summary
      pfam03164
      Location:114 → 531
      Mon1; Trafficking protein Mon1

    2. NM_173015.3 → NP_766603.1  vacuolar fusion protein MON1 homolog B

      See identical proteins and their annotated locations for NP_766603.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC125463, AK030288, BC062639, BY742778
      Consensus CDS
      CCDS22685.1
      UniProtKB/Swiss-Prot
      Q69ZX1, Q6P5V5, Q8BMQ8
      Related
      ENSMUSP00000045089.9, ENSMUST00000035777.10
      Conserved Domains (1) summary
      pfam03164
      Location:114 → 531
      Mon1; Trafficking protein Mon1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      114362218..114371824
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BMQ8.1 GenPept UniProtKB/Swiss-Prot:Q8BMQ8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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