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    Glcci1 glucocorticoid induced transcript 1 [ Mus musculus (house mouse) ]

    Gene ID: 170772, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Glcci1provided by MGI
    Official Full Name
    glucocorticoid induced transcript 1provided by MGI
    Primary source
    MGI:MGI:2179717
    See related
    Ensembl:ENSMUSG00000029638 AllianceGenome:MGI:2179717
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gig18; Tssn1; Fam117c; 2310047L21Rik; A130036A18Rik
    Summary
    Located in cytoplasm. Is expressed in several structures, including apical ectodermal ridge; axial skeleton; central nervous system; paraxial mesenchyme; and sensory organ. Orthologous to human GLCCI1 (glucocorticoid induced 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in thymus adult (RPKM 64.9), testis adult (RPKM 19.8) and 13 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Glcci1 in Genome Data Viewer
    Location:
    6 A1; 6 4.38 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (8509600..8597549)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (8509600..8597549)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A430035B10 gene Neighboring gene STARR-positive B cell enhancer ABC_E126 Neighboring gene predicted gene, 26075 Neighboring gene predicted gene, 52941 Neighboring gene F-box protein 5 Neighboring gene STARR-positive B cell enhancer ABC_E11313 Neighboring gene predicted gene, 35621 Neighboring gene STARR-positive B cell enhancer ABC_E8826 Neighboring gene STARR-seq mESC enhancer starr_15122 Neighboring gene islet cell autoantigen 1 Neighboring gene STARR-positive B cell enhancer ABC_E8827 Neighboring gene STARR-positive B cell enhancer ABC_E9660 Neighboring gene STARR-seq mESC enhancer starr_15123 Neighboring gene predicted gene, 53310 Neighboring gene predicted gene, 53311

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Isolation of differentially expressed sequence tags from steroid-responsive cells using mRNA differential display. Chapman MS, et al. Mol Cell Endocrinol, 1995 Feb 27. PMID 7758820
    2. GLCCI1 reduces collagen deposition and airway hyper-responsiveness in a mouse asthma model through binding with WD repeat domain 45B. Xun Q, et al. J Cell Mol Med, 2021 Jul. PMID 34050597, Free PMC Article
    3. Glucocorticoid induced transcript 1 represses airway remodeling of asthmatic mouse via inhibiting IL-13/periostin/TGF-β1 signaling. Xun Q, et al. Int Immunopharmacol, 2021 Aug. PMID 33895479
    4. Transcriptional control of steroid-regulated apoptosis in murine thymoma cells. Chapman MS, et al. Mol Endocrinol, 1996 Aug. PMID 8843413
    5. Involvement of GLCCI1 in mouse spermatogenesis. Takada M, et al. FASEB J, 2023 Jan. PMID 36468710

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GLCCI1 reduces collagen deposition and airway hyper-responsiveness in a mouse asthma model through binding with WD repeat domain 45B.
      Title: GLCCI1 reduces collagen deposition and airway hyper-responsiveness in a mouse asthma model through binding with WD repeat domain 45B.
    2. Glucocorticoid induced transcript 1 represses airway remodeling of asthmatic mouse via inhibiting IL-13/periostin/TGF-beta1 signaling.
      Title: Glucocorticoid induced transcript 1 represses airway remodeling of asthmatic mouse via inhibiting IL-13/periostin/TGF-β1 signaling.
    3. These findings suggest that Glcci1 is a new marker of a subpopulation of lateral ganglionic eminence ventricular zone progenitor cells in the Gsx2 lineage.
      Title: Characterization of Glcci1 expression in a subpopulation of lateral ganglionic eminence progenitors in the mouse telencephalon.
    4. Glcci1 promotes the normal development and maintenance of podocyte structure and function.
      Title: Glcci1 deficiency leads to proteinuria.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glucocorticoid-induced transcript 1 protein
    Names
    glucocorticoid-induced gene 18 protein
    testhymin
    thymocyte/spermatocyte selection protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286728.1 → NP_001273657.1  glucocorticoid-induced transcript 1 protein isoform 2

      See identical proteins and their annotated locations for NP_001273657.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes an alternate 5' terminal exon, initiates translation at a downstream start codon and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AK029524, AK037672, AV355078, AY098636, CA561411
      Consensus CDS
      CCDS71724.1
      UniProtKB/TrEMBL
      A0A0R4J1Z9
      Related
      ENSMUSP00000125079.2, ENSMUST00000162567.8
      Conserved Domains (1) summary
      pfam15388
      Location:1 → 281
      FAM117; Protein Family FAM117

    2. NM_001286729.1 → NP_001273658.1  glucocorticoid-induced transcript 1 protein isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) includes an alternate 5' terminal exon and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 3, which is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AK029524, AK037672, AV355078, AY098636
      Consensus CDS
      CCDS71725.1
      UniProtKB/Swiss-Prot
      Q8K3I9
      Related
      ENSMUSP00000124167.2, ENSMUST00000161217.8
      Conserved Domains (1) summary
      pfam15388
      Location:1 → 280
      FAM117; Protein Family FAM117

    3. NM_133236.3 → NP_573499.2  glucocorticoid-induced transcript 1 protein isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC156290, AK037672, AV355078, AY098636, BG081330, CN720421, DV652660
      Consensus CDS
      CCDS19910.2
      UniProtKB/Swiss-Prot
      Q80YT1, Q8CEA5, Q8K3I9, Q925C1
      UniProtKB/TrEMBL
      E9QKK4
      Related
      ENSMUSP00000069444.9, ENSMUST00000064285.15
      Conserved Domains (1) summary
      pfam15388
      Location:159 → 468
      FAM117; Protein Family FAM117

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      8509600..8597549
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K3I9.1 GenPept UniProtKB/Swiss-Prot:Q8K3I9

    Gene LinkOut

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