Pdcd5 programmed cell death 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pdcd5provided by MGI
Official Full Name: programmed cell death 5provided by MGI
Primary source: MGI:MGI:1913538
See related: Ensembl:ENSMUSG00000030417 AllianceGenome:MGI:1913538
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tfar19; 2200003D22Rik
Summary: Predicted to enable acetyltransferase activator activity; beta-tubulin binding activity; and heparin binding activity. Predicted to be involved in several processes, including negative regulation of chaperone-mediated protein folding; positive regulation of macromolecule metabolic process; and regulation of mitochondrion organization. Predicted to act upstream of or within apoptotic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Orthologous to human PDCD5 (programmed cell death 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 28.1), CNS E11.5 (RPKM 21.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B2; 7 21.37 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (35341410..35346907, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (35641985..35647482, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Programmed cell death 5 improves skeletal muscle insulin resistance by inhibiting IRS-1 ubiquitination through stabilization of MDM2.
Title: Programmed cell death 5 improves skeletal muscle insulin resistance by inhibiting IRS-1 ubiquitination through stabilization of MDM2.
Club cell-specific role of programmed cell death 5 in pulmonary fibrosis.
Title: Club cell-specific role of programmed cell death 5 in pulmonary fibrosis.
PDCD5 regulates iNKT cell terminal maturation and iNKT1 fate decision.
Title: PDCD5 regulates iNKT cell terminal maturation and iNKT1 fate decision.
serum PDCD5 levels reflect endothelial NO production and are correlated with diabetes mellitus, high-density lipoprotein cholesterol, and coronary calcium
Title: Programmed cell death 5 suppresses AKT-mediated cytoprotection of endothelium.
Pdcd5 knockout in mouse embryos results in placental defects and embryonic lethality.
Title: Deletion of Pdcd5 in mice led to the deficiency of placenta development and embryonic lethality.
These data demonstrate an association between level of PDCD5 and asthma severity and indicate that PDCD5 may play a role in allergic asthma.
Title: Overexpression of programmed cell death 5 in a mouse model of ovalbumin-induced allergic asthma.
PDCD5 gene knockout mice presented obvious improved brain blood flow, improved neurological behavior and decreased cerebral infarction compared with wild type mice. mice lacking PDCD5 had no changes in the expression of VHL and have slighter increases in the expression of HIF-1alpha and BNIP3, suggesting that PDCD5 may regulate apoptosis and autophagy through VHL-HIF-1alpha-BNIP3 pathway.
Title: Knockout of programmed cell death 5 (PDCD5) gene attenuates neuron injury after middle cerebral artery occlusion in mice.
PDCD5 selectively mediates HDAC3 dissociation from p53, which induces HDAC3 cleavage and ubiquitin-dependent proteasomal degradation. This is a a mechanism for p53 activation via PDCD5-dependent HDAC3 decay under genotoxic stress conditions.
Title: Programmed cell death 5 mediates HDAC3 decay to promote genotoxic stress response.
These findings uncovered an apoptotic signaling cascade linking YAF2, PDCD5, and TP53 during genotoxic stress responses.
Title: YAF2 promotes TP53-mediated genotoxic stress response via stabilization of PDCD5.
Transgenic mice with systemic overexpression of human PDCD5 were protected from cardiac remodeling.
Title: PDCD5 protects against cardiac remodeling by regulating autophagy and apoptosis.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125803 (e-PCR)
- UniSTS:162549

NoName (e-PCR)
- UniSTS:488702

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables acetyltransferase activator activity	ISO Inferred from Sequence Orthology more info
enables beta-tubulin binding	ISO Inferred from Sequence Orthology more info
enables heparin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in cellular response to transforming growth factor beta stimulus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of chaperone-mediated protein folding	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein insertion into mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of release of cytochrome c from mitochondria	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: programmed cell death protein 5

Names: TF-1 cell apoptosis-related protein 19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019746.4 → NP_062720.1 programmed cell death protein 5

See identical proteins and their annotated locations for NP_062720.1

Status: PROVISIONAL

Source sequence(s)

AC151531

Consensus CDS

CCDS52203.1

UniProtKB/Swiss-Prot

P56812

UniProtKB/TrEMBL

Q564F6

Related

ENSMUSP00000113761.2, ENSMUST00000118501.8

Conserved Domains (1) summary

pfam01984
Location:9 → 101

dsDNA_bind; Double-stranded DNA-binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

35341410..35346907 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036153270.1 → XP_036009163.1 programmed cell death protein 5 isoform X1

Conserved Domains (1) summary

cl00928
Location:100 → 142

dsDNA_bind; Double-stranded DNA-binding domain