Cdk8 cyclin dependent kinase 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cdk8provided by MGI
Official Full Name: cyclin dependent kinase 8provided by MGI
Primary source: MGI:MGI:1196224
See related: Ensembl:ENSMUSG00000029635 AllianceGenome:MGI:1196224
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in G1/S transition of mitotic cell cycle and positive regulation of transcription by RNA polymerase II. Part of mediator complex. Is expressed in embryo; tibialis anterior; and tongue. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human CDK8 (cyclin dependent kinase 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 21.2), ovary adult (RPKM 18.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G3; 5 85.19 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (146167432..146239684)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (146230795..146302874)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cdk8 and Hira mutations trigger X chromosome elimination in naive female hybrid mouse embryonic stem cells.
Title: Cdk8 and Hira mutations trigger X chromosome elimination in naive female hybrid mouse embryonic stem cells.
Transcriptome-based chemical screens identify CDK8 as a common barrier in multiple cell reprogramming systems.
Title: Transcriptome-based chemical screens identify CDK8 as a common barrier in multiple cell reprogramming systems.
CDK8 and CDK19 act redundantly to control the CFTR pathway in the intestinal epithelium.
Title: CDK8 and CDK19 act redundantly to control the CFTR pathway in the intestinal epithelium.
The role of CDK8 in mesenchymal stem cells in controlling osteoclastogenesis and bone homeostasis.
Title: The role of CDK8 in mesenchymal stem cells in controlling osteoclastogenesis and bone homeostasis.
MiR-382-5p suppresses M1 macrophage polarization and inflammatory response in response to bronchopulmonary dysplasia through targeting CDK8: Involving inhibition of STAT1 pathway.
Title: MiR-382-5p suppresses M1 macrophage polarization and inflammatory response in response to bronchopulmonary dysplasia through targeting CDK8: Involving inhibition of STAT1 pathway.
Cdk8 is required for establishment of H3K27me3 and gene repression by Xist and mouse development.
Title: Cdk8 is required for establishment of H3K27me3 and gene repression by Xist and mouse development.
MiR-297 alleviates LPS-induced A549 cell and mice lung injury via targeting cyclin dependent kinase 8.
Title: MiR-297 alleviates LPS-induced A549 cell and mice lung injury via targeting cyclin dependent kinase 8.
CDK8 Regulates Insulin Secretion and Mediates Postnatal and Stress-Induced Expression of Neuropeptides in Pancreatic beta Cells.
Title: CDK8 Regulates Insulin Secretion and Mediates Postnatal and Stress-Induced Expression of Neuropeptides in Pancreatic β Cells.
FBXL19 and CDK-Mediator support long-range interactions between silent gene promoters that rely on FBXL19 for their induction during differentiation and gene regulatory elements.
Title: CDK-Mediator and FBXL19 prime developmental genes for activation by promoting atypical regulatory interactions.
Both genetic and pharmacological inhibition of CDK8 and its homologous twin kinase CDK19 leads to abrogation of BMP4-induced EMT.
Title: Mediator kinase CDK8/CDK19 drives YAP1-dependent BMP4-induced EMT in cancer.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (2) 1 citation
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:235370

Cdk8 (e-PCR), detects polymorphism
- UniSTS:527280

05.MMHAP5FRB8.seq (e-PCR)
- UniSTS:122823

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S2 kinase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S5 kinase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S7 kinase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat T4 kinase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat Y1 kinase activity	IEA Inferred from Electronic Annotation more info
enables cyclin-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of triglyceride metabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of CKM complex	IEA Inferred from Electronic Annotation more info
part_of CKM complex	ISO Inferred from Sequence Orthology more info
part_of cyclin-dependent protein kinase holoenzyme complex	ISO Inferred from Sequence Orthology more info
part_of mediator complex	IDA Inferred from Direct Assay more info	PubMed
part_of mediator complex	ISO Inferred from Sequence Orthology more info	PubMed
located_in nucleolus	ISO Inferred from Sequence Orthology more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info	PubMed
part_of ubiquitin ligase complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cyclin-dependent kinase 8

Names: cell division protein kinase 8; mediator complex subunit CDK8; mediator of RNA polymerase II transcription subunit CDK8

NP_001346919.1

EC 2.7.11.22

EC 2.7.11.23

NP_001346920.1

EC 2.7.11.22

EC 2.7.11.23

NP_705827.2

EC 2.7.11.22

EC 2.7.11.23

XP_006504899.1

EC 2.7.11.22

EC 2.7.11.23

XP_006504901.1

EC 2.7.11.22

EC 2.7.11.23

XP_006504902.1

EC 2.7.11.22

EC 2.7.11.23

XP_006504903.1

EC 2.7.11.22

EC 2.7.11.23

XP_030110375.1

EC 2.7.11.22

EC 2.7.11.23

XP_036021035.1

EC 2.7.11.22

EC 2.7.11.23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001359990.1 → NP_001346919.1 cyclin-dependent kinase 8 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.

Source sequence(s)

AC113316

Conserved Domains (1) summary

cd07868
Location:3 → 335

STKc_CDK8; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 8
NM_001359991.1 → NP_001346920.1 cyclin-dependent kinase 8 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (3) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 1.

Source sequence(s)

AC113316, AK131948

Consensus CDS

CCDS90018.1

UniProtKB/TrEMBL

E9Q6E2

Related

ENSMUSP00000125668.2, ENSMUST00000161181.8

Conserved Domains (1) summary

cl21453
Location:1 → 270

PKc_like; Protein Kinases, catalytic domain
NM_153599.4 → NP_705827.2 cyclin-dependent kinase 8 isoform 1

See identical proteins and their annotated locations for NP_705827.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC113316

Consensus CDS

CCDS19869.1

UniProtKB/Swiss-Prot

Q8R3L8

Related

ENSMUSP00000031640.9, ENSMUST00000031640.15

Conserved Domains (1) summary

cd07868
Location:3 → 335

STKc_CDK8; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

146167432..146239684

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006504836.5 → XP_006504899.1 cyclin-dependent kinase 8 isoform X1

UniProtKB/Swiss-Prot

Q8R3L8

Conserved Domains (1) summary

cl21453
Location:3 → 330

PKc_like; Protein Kinases, catalytic domain
XM_006504840.5 → XP_006504903.1 cyclin-dependent kinase 8 isoform X5

Conserved Domains (1) summary

cl21453
Location:3 → 287

PKc_like; Protein Kinases, catalytic domain
XM_030254515.2 → XP_030110375.1 cyclin-dependent kinase 8 isoform X6

Conserved Domains (1) summary

cl21453
Location:3 → 287

PKc_like; Protein Kinases, catalytic domain
XM_006504838.5 → XP_006504901.1 cyclin-dependent kinase 8 isoform X2

Conserved Domains (1) summary

cl21453
Location:3 → 322

PKc_like; Protein Kinases, catalytic domain
XM_006504839.5 → XP_006504902.1 cyclin-dependent kinase 8 isoform X3

Conserved Domains (1) summary

cl21453
Location:3 → 298

PKc_like; Protein Kinases, catalytic domain
XM_036165142.1 → XP_036021035.1 cyclin-dependent kinase 8 isoform X4

Conserved Domains (1) summary

cl21453
Location:3 → 298

PKc_like; Protein Kinases, catalytic domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_181570.1: Suppressed sequence

Description

NM_181570.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.