Fastk Fas-activated serine/threonine kinase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fastkprovided by MGI
Official Full Name: Fas-activated serine/threonine kinaseprovided by MGI
Primary source: MGI:MGI:1913837
See related: Ensembl:ENSMUSG00000028959 AllianceGenome:MGI:1913837
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 610011K02Rik; 0610011K02Rik
Summary: Predicted to enable RNA binding activity and protein serine/threonine kinase activity. Predicted to be involved in mitochondrial RNA processing; protein phosphorylation; and regulation of gene expression. Located in nuclear speck. Is expressed in brain; gut; male reproductive gland or organ; metanephros; and thoracic segment skeleton. Orthologous to human FASTK (Fas activated serine/threonine kinase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in heart adult (RPKM 133.9), colon adult (RPKM 87.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 A3; 5 11.78 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (24646036..24650280, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (24441038..24445295, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Accelerated FASTK mRNA degradation induced by oxidative stress is responsible for the destroyed myocardial mitochondrial gene expression and respiratory function in alcoholic cardiomyopathy.
Title: Accelerated FASTK mRNA degradation induced by oxidative stress is responsible for the destroyed myocardial mitochondrial gene expression and respiratory function in alcoholic cardiomyopathy.
Genetic ablation of Fas-activated serine/threonine kinase ameliorates obesity-related hepatic glucose and lipid metabolic disorders via sirtuin-1 signaling.
Title: Genetic ablation of Fas-activated serine/threonine kinase ameliorates obesity-related hepatic glucose and lipid metabolic disorders via sirtuin-1 signaling.
our results clearly demonstrate for the first time, to our knowledge, that mitoFASTK plays a negative regulatory role on nonopsonic phagocytosis of bacteria in macrophages through its action on mitochondrial respiratory complex I activity.
Title: The Mitochondrial Isoform of FASTK Modulates Nonopsonic Phagocytosis of Bacteria by Macrophages via Regulation of Respiratory Complex I.
In a well-established model of allergic pulmonary inflammation, FAST is a proinflammatory factor that modulates the function of lung resident hematopoietic cells to promote neutrophil recruitment and pulmonary inflammation.
Title: Fas-activated serine/threonine phosphoprotein promotes immune-mediated pulmonary inflammation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)
Targeted (3) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables Fas-activated serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial RNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of RNA splicing	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitochondrial mRNA stability	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mitochondrial mRNA stability	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in nuclear speck	IDA Inferred from Direct Assay more info	PubMed
is_active_in ribonucleoprotein granule	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: fas-activated serine/threonine kinase

Names: FAST kinase

NP_075718.2

EC 2.7.11.1

EC 2.7.11.8

XP_017176555.1

EC 2.7.11.1

EC 2.7.11.8

XP_017176556.1

EC 2.7.11.1

EC 2.7.11.8

XP_030110621.1

EC 2.7.11.1

EC 2.7.11.8

XP_036021302.1

EC 2.7.11.1

EC 2.7.11.8

XP_036021303.1

EC 2.7.11.1

EC 2.7.11.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023229.2 → NP_075718.2 fas-activated serine/threonine kinase

See identical proteins and their annotated locations for NP_075718.2

Status: VALIDATED

Source sequence(s)

AK152369

Consensus CDS

CCDS19120.1

UniProtKB/TrEMBL

Q8C725, Q8CAK5

Related

ENSMUSP00000030800.7, ENSMUST00000030800.13

Conserved Domains (3) summary

smart00952
Location:480 → 532

RAP; This domain is found in various eukaryotic species, particularly in apicomplexans

pfam06743
Location:274 → 339

FAST_1; FAST kinase-like protein, subdomain 1

pfam08368
Location:354 → 439

FAST_2; FAST kinase-like protein, subdomain 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

24646036..24650280 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017321066.2 → XP_017176555.1 fas-activated serine/threonine kinase isoform X1

UniProtKB/Swiss-Prot

Q9JIX9

UniProtKB/TrEMBL

Q91WQ6

Conserved Domains (3) summary

smart00952
Location:446 → 498

RAP; This domain is found in various eukaryotic species, particularly in apicomplexans

pfam06743
Location:240 → 305

FAST_1; FAST kinase-like protein, subdomain 1

pfam08368
Location:318 → 405

FAST_2; FAST kinase-like protein, subdomain 2
XM_036165410.1 → XP_036021303.1 fas-activated serine/threonine kinase isoform X2

UniProtKB/TrEMBL

E9QA06

Conserved Domains (3) summary

smart00952
Location:332 → 384

RAP; This domain is found in various eukaryotic species, particularly in apicomplexans

pfam06743
Location:126 → 191

FAST_1; FAST kinase-like protein, subdomain 1

pfam08368
Location:204 → 291

FAST_2; FAST kinase-like protein, subdomain 2
XM_017321067.3 → XP_017176556.1 fas-activated serine/threonine kinase isoform X1

UniProtKB/Swiss-Prot

Q9JIX9

UniProtKB/TrEMBL

Q91WQ6

Conserved Domains (3) summary

smart00952
Location:446 → 498

RAP; This domain is found in various eukaryotic species, particularly in apicomplexans

pfam06743
Location:240 → 305

FAST_1; FAST kinase-like protein, subdomain 1

pfam08368
Location:318 → 405

FAST_2; FAST kinase-like protein, subdomain 2
XM_036165409.1 → XP_036021302.1 fas-activated serine/threonine kinase isoform X1

UniProtKB/Swiss-Prot

Q9JIX9

UniProtKB/TrEMBL

Q91WQ6

Related

ENSMUST00000149085.8

Conserved Domains (3) summary

smart00952
Location:446 → 498

RAP; This domain is found in various eukaryotic species, particularly in apicomplexans

pfam06743
Location:240 → 305

FAST_1; FAST kinase-like protein, subdomain 1

pfam08368
Location:318 → 405

FAST_2; FAST kinase-like protein, subdomain 2
XM_030254761.2 → XP_030110621.1 fas-activated serine/threonine kinase isoform X2

UniProtKB/TrEMBL

E9QA06

Related

ENSMUSP00000110693.2, ENSMUST00000115041.2

Conserved Domains (3) summary

smart00952
Location:332 → 384

RAP; This domain is found in various eukaryotic species, particularly in apicomplexans

pfam06743
Location:126 → 191

FAST_1; FAST kinase-like protein, subdomain 1

pfam08368
Location:204 → 291

FAST_2; FAST kinase-like protein, subdomain 2