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    Bcap29 B cell receptor associated protein 29 [ Mus musculus (house mouse) ]

    Gene ID: 12033, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Bcap29provided by MGI
    Official Full Name
    B cell receptor associated protein 29provided by MGI
    Primary source
    MGI:MGI:101917
    See related
    Ensembl:ENSMUSG00000020650 AllianceGenome:MGI:101917
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bap29
    Summary
    Acts upstream of or within endoplasmic reticulum to Golgi vesicle-mediated transport and protein localization to endoplasmic reticulum exit site. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including ganglia; gut; submandibular gland primordium; telencephalon ventricular layer; and vibrissa. Orthologous to human BCAP29 (B cell receptor associated protein 29). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis adult (RPKM 21.6), cortex adult (RPKM 9.1) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Bcap29 in Genome Data Viewer
    Location:
    12 A2- A3; 12 13.63 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (31645353..31684657, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (31595354..31634658, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene Casitas B-lineage lymphoma-like 1 Neighboring gene predicted gene, 40362 Neighboring gene solute carrier family 26, member 4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:32339618-32339801 Neighboring gene STARR-seq mESC enhancer starr_31859 Neighboring gene dihydrouridine synthase 4 like Neighboring gene component of oligomeric golgi complex 5 Neighboring gene G protein-coupled receptor 22

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Two new proteins preferentially associated with membrane immunoglobulin D. Kim KM, et al. EMBO J, 1994 Aug 15. PMID 8070407, Free PMC Article
    2. The IgM antigen receptor of B lymphocytes is associated with prohibitin and a prohibitin-related protein. Terashima M, et al. EMBO J, 1994 Aug 15. PMID 8070406, Free PMC Article
    3. Bap29/31 influences the intracellular traffic of MHC class I molecules. Paquet ME, et al. J Immunol, 2004 Jun 15. PMID 15187134
    4. A high-molecular-weight complex of membrane proteins BAP29/BAP31 is involved in the retention of membrane-bound IgD in the endoplasmic reticulum. Schamel WW, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12886015, Free PMC Article
    5. In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype. Gineste C, et al. Neuromuscul Disord, 2013 Apr. PMID 23375831

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A high-molecular-weight complex of membrane proteins BAP29/BAP31 is involved in the retention of membrane-bound IgD in the endoplasmic reticulum.
      Title: A high-molecular-weight complex of membrane proteins BAP29/BAP31 is involved in the retention of membrane-bound IgD in the endoplasmic reticulum.
    2. results are consistent with the view that class I molecules are largely recruited to ER exit sites by Bap29/31, and that Bap29/31 is a cargo receptor for MHC class I molecules
      Title: Bap29/31 influences the intracellular traffic of MHC class I molecules.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within endoplasmic reticulum to Golgi vesicle-mediated transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to endoplasmic reticulum exit site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein localization to endoplasmic reticulum exit site IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    B-cell receptor-associated protein 29
    Names
    BCR-associated protein 29

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164090.1 → NP_001157562.1  B-cell receptor-associated protein 29

      See identical proteins and their annotated locations for NP_001157562.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC119950
      Consensus CDS
      CCDS25864.1
      UniProtKB/Swiss-Prot
      Q61334
      UniProtKB/TrEMBL
      Q542A1
      Related
      ENSMUSP00000137260.2, ENSMUST00000177962.9
      Conserved Domains (1) summary
      pfam05529
      Location:1 → 219
      Bap31; B-cell receptor-associated protein 31-like

    2. NM_007530.3 → NP_031556.1  B-cell receptor-associated protein 29

      See identical proteins and their annotated locations for NP_031556.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC119950
      Consensus CDS
      CCDS25864.1
      UniProtKB/Swiss-Prot
      Q61334
      UniProtKB/TrEMBL
      Q542A1
      Related
      ENSMUSP00000020979.8, ENSMUST00000020979.9
      Conserved Domains (1) summary
      pfam05529
      Location:1 → 219
      Bap31; B-cell receptor-associated protein 31-like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      31645353..31684657 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61334.1 GenPept UniProtKB/Swiss-Prot:Q61334

    Gene LinkOut

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