Gap43 growth associated protein 43 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gap43provided by RGD
Official Full Name: growth associated protein 43provided by RGD
Primary source: RGD:62071
See related: EnsemblRapid:ENSRNOG00000001528 AllianceGenome:RGD:62071
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Basp2
Summary: Enables lysophosphatidic acid binding activity; phosphatidylinositol phosphate binding activity; and phosphatidylserine binding activity. Involved in several processes, including regulation of postsynaptic specialization assembly; response to auditory stimulus; and tissue regeneration. Is active in GABA-ergic synapse and presynapse. Biomarker of middle cerebral artery infarction and visual epilepsy. Orthologous to human GAP43 (growth associated protein 43). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 663.7) See more
Orthologs: human mouse all
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Genomic context

Location:: 11q21

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (71882131..71975799)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (58376371..58470047)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (58624198..58717916)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

P53-induced GAP-43 Upregulation in Primary Cortical Neurons of Rats.
Title: P53-induced GAP-43 Upregulation in Primary Cortical Neurons of Rats.
Vof16-miR-185-5p-GAP43 network improves the outcomes following spinal cord injury via enhancing self-repair and promoting axonal growth.
Title: Vof16-miR-185-5p-GAP43 network improves the outcomes following spinal cord injury via enhancing self-repair and promoting axonal growth.
Paternal stress alters synaptic density and expression of GAP-43, GRIN1, M1 and SYP genes in the hippocampus and cortex of offspring of stress-induced male rats.
Title: Paternal stress alters synaptic density and expression of GAP-43, GRIN1, M1 and SYP genes in the hippocampus and cortex of offspring of stress-induced male rats.
NEP140 promotes myelin regeneration via upregulation of GAP43 and MAP2 expression after focal cerebral ischemia in rats.
Title: NEP1‑40 promotes myelin regeneration via upregulation of GAP‑43 and MAP‑2 expression after focal cerebral ischemia in rats.
The effects of exercise training on Kinesin and GAP-43 expression in skeletal muscle fibers of STZ-induced diabetic rats.
Title: The effects of exercise training on Kinesin and GAP-43 expression in skeletal muscle fibers of STZ-induced diabetic rats.
Effects of repetitive magnetic stimulation on motor function and GAP43 and 5-HT expression in rats with spinal cord injury.
Title: Effects of repetitive magnetic stimulation on motor function and GAP43 and 5-HT expression in rats with spinal cord injury.
The inhibition of miR-17-5p promotes cortical neuron neurite growth via STAT3/GAP-43 pathway.
Title: The inhibition of miR-17-5p promotes cortical neuron neurite growth via STAT3/GAP-43 pathway.
GAP43 protein expression in the hippocampus in the chronic intermittent hypoxia rats.
Title: Changes and Significance of SYP and GAP-43 Expression in the Hippocampus of CIH Rats.
Study shows that functional ectopic neural lobe increases GAP-43 expression via PI3K/AKT pathways to alleviate central diabetes insipidus after pituitary stalk lesion in rats.
Title: Functional ectopic neural lobe increases GAP-43 expression via PI3K/AKT pathways to alleviate central diabetes insipidus after pituitary stalk lesion in rats.
Hippocampal GAP-43 levels is sensitive to different exercise intensities.Highest corticosterone level and lactate production leads to reduction and induction of hippocampal GAP-43.
Title: Various exercise intensities differentially regulate GAP-43 and CAP-1 expression in the rat hippocampus.

Submit: New GeneRIF Correction See all GeneRIFs (104)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU048143 (e-PCR)
- UniSTS:109829

PMC337033P3 (e-PCR)
- UniSTS:273167

PMC17794P1 (e-PCR)
- UniSTS:271648

Gap43 (e-PCR), detects polymorphism
- UniSTS:465476

GAP43 (e-PCR)
- UniSTS:479844

UniSTS:265709 (e-PCR)
- UniSTS:265709

Gap43 (e-PCR), detects polymorphism
- UniSTS:265709

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calmodulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables lysophosphatidic acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables lysophosphatidic acid binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol phosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol phosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylserine binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylserine binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within astrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in axon choice point recognition	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within axon choice point recognition	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within axon guidance	ISO Inferred from Sequence Orthology more info
involved_in axon regeneration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell fate commitment	ISO Inferred from Sequence Orthology more info
involved_in nervous system development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within radial glial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of filopodium assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of growth	IEA Inferred from Electronic Annotation more info
involved_in regulation of postsynaptic specialization assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic specialization assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to auditory stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in tissue regeneration	IBA Inferred from Biological aspect of Ancestor more info
involved_in tissue regeneration	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in GABA-ergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in axon	ISO Inferred from Sequence Orthology more info
located_in cell periphery	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in filopodium membrane	ISO Inferred from Sequence Orthology more info
located_in growth cone	TAS Traceable Author Statement more info	PubMed
located_in growth cone membrane	IEA Inferred from Electronic Annotation more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
is_active_in presynapse	IDA Inferred from Direct Assay more info	PubMed
located_in presynapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: neuromodulin

Names: axonal membrane protein GAP-43; brain abundant, membrane attached signal protein 2; growth accentuating protein 43; protein F1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.