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    Fgf1 fibroblast growth factor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25317, updated on 27-Nov-2024

    Summary

    Official Symbol
    Fgf1provided by RGD
    Official Full Name
    fibroblast growth factor 1provided by RGD
    Primary source
    RGD:2605
    See related
    EnsemblRapid:ENSRNOG00000087149 AllianceGenome:RGD:2605
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    FGF-1; Fgf2b; HBGF1; HBGF-1
    Summary
    Enables Hsp70 protein binding activity and growth factor activity. Involved in positive regulation of hepatocyte proliferation. Predicted to be located in several cellular components, including cytosol; extracellular matrix; and nucleoplasm. Predicted to be active in cytoplasm; extracellular space; and nucleus. Used to study brain ischemia. Human ortholog(s) of this gene implicated in brain ischemia; cleft lip; myocardial infarction; schizophrenia; and urinary bladder cancer. Orthologous to human FGF1 (fibroblast growth factor 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 331.5), Kidney (RPKM 144.8) and 5 other tissues See more
    Orthologs
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    Genomic context

    See Fgf1 in Genome Data Viewer
    Location:
    18p11
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (30937670..31023786, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (30686555..30772667, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (32273830..32359831)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482935 Neighboring gene Rho GTPase activating protein 26 Neighboring gene small ribosomal subunit protein uS5-like Neighboring gene uncharacterized LOC120098315 Neighboring gene Cytochrome c oxidase subunit 7C, pseudogene 2 Neighboring gene uncharacterized LOC134482937

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables Hsp70 protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables S100 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables S100 protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables fibroblast growth factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables fibroblast growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables fibroblast growth factor receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables growth factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables growth factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables growth factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables heparin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables heparin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables integrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables integrin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in activation of protein kinase B activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in activation of protein kinase B activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in branch elongation involved in ureteric bud branching ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in branch elongation involved in ureteric bud branching ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to heat ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to heat ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fibroblast growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fibroblast growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fibroblast growth factor receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within lung development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mesonephric epithelium development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mesonephric epithelium development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in neurogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within organ induction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cell division ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell division ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cholesterol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cholesterol biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of endothelial cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within positive regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of hepatocyte proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of intracellular signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of sprouting angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of endothelial cell chemotaxis to fibroblast growth factor ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of endothelial tube morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of endothelial tube morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in wound healing ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    fibroblast growth factor 1
    Names
    Fibroblast growth factor 1 (heparin binding)
    aFGF
    acidic fibroblast growth factor
    fibroblast growth factor 1 (acidic)
    fibroblast growth factor 2b
    heparin-binding growth factor 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012846.2NP_036978.1  fibroblast growth factor 1

      See identical proteins and their annotated locations for NP_036978.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/Swiss-Prot
      P61149
      UniProtKB/TrEMBL
      A0A7U3JW64
      Conserved Domains (1) summary
      pfam00167
      Location:25148
      FGF; Fibroblast growth factor

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      30937670..31023786 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006254650.5XP_006254712.1  fibroblast growth factor 1 isoform X1

      See identical proteins and their annotated locations for XP_006254712.1

      UniProtKB/Swiss-Prot
      P61149
      UniProtKB/TrEMBL
      A0A7U3JW64
      Conserved Domains (1) summary
      pfam00167
      Location:25148
      FGF; Fibroblast growth factor
    2. XM_039096591.2XP_038952519.1  fibroblast growth factor 1 isoform X2

      Related
      ENSRNOP00000099489.1, ENSRNOT00000135040.1
      Conserved Domains (1) summary
      pfam00167
      Location:25147
      FGF; Fibroblast growth factor
    3. XM_006254652.5XP_006254714.1  fibroblast growth factor 1 isoform X1

      See identical proteins and their annotated locations for XP_006254714.1

      UniProtKB/Swiss-Prot
      P61149
      UniProtKB/TrEMBL
      A0A7U3JW64
      Conserved Domains (1) summary
      pfam00167
      Location:25148
      FGF; Fibroblast growth factor
    4. XM_006254651.5XP_006254713.1  fibroblast growth factor 1 isoform X1

      See identical proteins and their annotated locations for XP_006254713.1

      UniProtKB/Swiss-Prot
      P61149
      UniProtKB/TrEMBL
      A0A7U3JW64
      Conserved Domains (1) summary
      pfam00167
      Location:25148
      FGF; Fibroblast growth factor