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    Itpka inositol-trisphosphate 3-kinase A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81677, updated on 27-Nov-2024

    Summary

    Official Symbol
    Itpkaprovided by RGD
    Official Full Name
    inositol-trisphosphate 3-kinase Aprovided by RGD
    Primary source
    RGD:619950
    See related
    EnsemblRapid:ENSRNOG00000005284 AllianceGenome:RGD:619950
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables calcium/calmodulin-dependent protein kinase activity; inositol-1,4,5-trisphosphate 3-kinase activity; and small GTPase binding activity. Involved in modification of postsynaptic actin cytoskeleton. Acts upstream of or within actin cytoskeleton organization; dendritic spine maintenance; and positive regulation of dendritic spine morphogenesis. Located in dendritic spine. Is active in glutamatergic synapse and postsynaptic actin cytoskeleton. Orthologous to human ITPKA (inositol-trisphosphate 3-kinase A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 127.2), Testes (RPKM 126.0) and 3 other tissues See more
    Orthologs
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    Genomic context

    See Itpka in Genome Data Viewer
    Location:
    3q35
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (127179841..127188405)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (106726036..106734601)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (111545007..111553605)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene nucleolar and spindle associated protein 1 Neighboring gene 40S ribosomal protein S20 pseudogene Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 1 Neighboring gene Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) Neighboring gene leukocyte receptor tyrosine kinase Neighboring gene RNA polymerase II associated protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium/calmodulin-dependent protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables inositol hexakisphosphate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables inositol-1,4,5-trisphosphate 3-kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables inositol-1,4,5-trisphosphate 3-kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables inositol-1,4,5-trisphosphate 3-kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables small GTPase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin cytoskeleton organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to calcium ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to calcium ion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within dendritic spine maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within inositol metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in inositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in modification of postsynaptic actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in modification of postsynaptic actin cytoskeleton IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in modification of postsynaptic actin cytoskeleton IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in phosphatidylinositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phosphatidylinositol phosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphatidylinositol phosphate biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within positive regulation of dendritic spine morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of synaptic plasticity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to calcium ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to calcium ion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in dendritic spine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in postsynaptic actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynaptic actin cytoskeleton IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    inositol-trisphosphate 3-kinase A
    Names
    IP3 3-kinase A
    IP3K A
    inositol 1,4,5-triphosphate 3-kinase
    inositol 1,4,5-trisphosphate 3-kinase A
    inositol 145-triphosphate 3-kinase
    insP 3-kinase A
    NP_112307.2
    XP_038961845.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031045.2NP_112307.2  inositol-trisphosphate 3-kinase A

      See identical proteins and their annotated locations for NP_112307.2

      Status: VALIDATED

      Source sequence(s)
      BQ204027, JAXUCZ010000003, M29787
      UniProtKB/Swiss-Prot
      P17105
      UniProtKB/TrEMBL
      A6HPH2, A6HPH3
      Related
      ENSRNOP00000007247.1, ENSRNOT00000007247.5
      Conserved Domains (1) summary
      pfam03770
      Location:243453
      IPK; Inositol polyphosphate kinase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      127179841..127188405
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039105917.2XP_038961845.1  inositol-trisphosphate 3-kinase A isoform X1

      Conserved Domains (1) summary
      pfam03770
      Location:116326
      IPK; Inositol polyphosphate kinase