tomm22 translocase of outer mitochondrial membrane 22 homolog (yeast) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tomm22provided by ZNC
Official Full Name: translocase of outer mitochondrial membrane 22 homolog (yeast)provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-9810
See related: Ensembl:ENSDARG00000045146 AllianceGenome:ZFIN:ZDB-GENE-030131-9810
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb381; sb:cb381; zgc:86742
Summary: Acts upstream of or within liver development. Predicted to be located in mitochondrial outer membrane. Is expressed in EVL; digestive system; epidermis; notochord; and periderm. Orthologous to human TOMM22 (translocase of outer mitochondrial membrane 22). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (19348527..19353771)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (19226653..19231897)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

tomm22 has a role in hepatocyte cell death, affecting wnt and beta-catenin in liver regneration
Title: tomm22 Knockdown-Mediated Hepatocyte Damages Elicit Both the Formation of Hybrid Hepatocytes and Biliary Conversion to Hepatocytes in Zebrafish Larvae.
The specificity and reversibility of hepatocyte ablation after temporary knockdown of Tomm22 provides an additional model to study liver regeneration, under conditions where most hepatocytes have died.
Title: The mitochondrial import gene tomm22 is specifically required for hepatocyte survival and provides a liver regeneration model.

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General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within intracellular protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within liver development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: mitochondrial import receptor subunit TOM22 homolog

Names: mitochondrial import receptor Tom22; oli

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.