Frmd8 FERM domain containing 8 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Frmd8provided by RGD
Official Full Name: FERM domain containing 8provided by RGD
Primary source: RGD:1310323
See related: EnsemblRapid:ENSRNOG00000020881 AllianceGenome:RGD:1310323
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1310323
Summary: Predicted to be involved in negative regulation of canonical Wnt signaling pathway and positive regulation of tumor necrosis factor production. Predicted to act upstream of or within protein localization to plasma membrane. Predicted to be located in centriolar satellite; cytosol; and nucleoplasm. Predicted to be active in plasma membrane. Orthologous to several human genes including FRMD8 (FERM domain containing 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 95.2), Adrenal (RPKM 92.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q43

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (212572534..212593181, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (203143216..203163868, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (221213312..221233967, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in negative regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor production	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in centriolar satellite	IEA Inferred from Electronic Annotation more info
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: FERM domain-containing protein 8

Names: FKSG44 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008348.1 → NP_001008349.1 FERM domain-containing protein 8

See identical proteins and their annotated locations for NP_001008349.1

Status: PROVISIONAL

Source sequence(s)

BC085896

UniProtKB/Swiss-Prot

Q5U2R3

UniProtKB/TrEMBL

A0A1B0GWW6, A6HZA5

Related

ENSRNOP00000095691.1, ENSRNOT00000113145.2

Conserved Domains (1) summary

pfam00373
Location:141 → 273

FERM_M; FERM central domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

212572534..212593181 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063264380.1 → XP_063120450.1 FERM domain-containing protein 8 isoform X2
XM_006230804.5 → XP_006230866.1 FERM domain-containing protein 8 isoform X1

UniProtKB/TrEMBL

A0A1B0GWW6

Conserved Domains (2) summary

smart00295
Location:31 → 272

B41; Band 4.1 homologues

pfam00373
Location:140 → 272

FERM_M; FERM central domain