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    Ldhc lactate dehydrogenase C [ Mus musculus (house mouse) ]

    Gene ID: 16833, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ldhcprovided by MGI
    Official Full Name
    lactate dehydrogenase Cprovided by MGI
    Primary source
    MGI:MGI:96764
    See related
    Ensembl:ENSMUSG00000030851 AllianceGenome:MGI:96764
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ldh3; Ldh-3; Ldh-x; Ldhc4; LDH-C4
    Summary
    Enables L-lactate dehydrogenase activity. Involved in pyruvate catabolic process. Acts upstream of or within ATP biosynthetic process; flagellated sperm motility; and lactate biosynthetic process from pyruvate. Located in cytoplasm and motile cilium. Is active in cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human LDHC (lactate dehydrogenase C). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward testis adult (RPKM 1111.1) See more
    Orthologs
    human all
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    Genomic context

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    See Ldhc in Genome Data Viewer
    Location:
    7 B3; 7 30.6 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (46510687..46527571)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (46861263..46878147)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_18874 Neighboring gene predicted gene 5331 Neighboring gene lactate dehydrogenase A Neighboring gene predicted gene, 39011 Neighboring gene tumor susceptibility gene 101 Neighboring gene STARR-seq mESC enhancer starr_18876 Neighboring gene UEV and lactate/malate dehyrogenase domains Neighboring gene predicted gene, 39012

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The structure of mouse testicular lactate dehydrogenase isoenzyme C4 at 2.9 A resolution. Musick WD, et al. J Biol Chem, 1979 Aug 25. PMID 468772
    2. cDNA copies of the testis-specific lactate dehydrogenase (LDH-C) mRNA are present in spermatogenic cells in mice, but processed pseudogenes are not derived from mRNAs that are expressed in haploid and late meiotic spermatogenic cells. Zhong X, et al. Mamm Genome, 1999 Jan. PMID 9892725
    3. Transgenic mice demonstrate a testis-specific promoter for lactate dehydrogenase, LDHC. Li S, et al. J Biol Chem, 1998 Nov 20. PMID 9813024
    4. Generation of humanized LDHC knock-in mice as a tool to assess human LDHC-targeting contraceptive drugs. Iida-Norita R, et al. Andrology, 2023 Jul. PMID 36464740
    5. A transgenic analysis of mouse lactate dehydrogenase C promoter activity in the testis. Kroft TL, et al. J Androl, 2003 Nov-Dec. PMID 14581510

    See all (80) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the LDHA protein level was remarkably decreased in Ldhc-deficient sperm, indicating that LDHC is required for LDHA expression in the sperm.
      Title: Lactate dehydrogenase C is required for the protein expression of a sperm-specific isoform of lactate dehydrogenase A.
    2. polymorphisms in the Ldhc gene control testis levels of S-2HG, and thereby epigenetics, across mammals
      Title: Lactate Dehydrogenase C Produces S-2-Hydroxyglutarate in Mouse Testis.
    3. Human LDHA was introduced as a transgene to Ldhc-null mice and rescued sperm function.
      Title: Human lactate dehydrogenase A (LDHA) rescues mouse Ldhc-null sperm function.
    4. C57BL/6 and 129S6 Ldhc KO mice were subfertile and infertile respectively.
      Title: Glycolysis and mitochondrial respiration in mouse LDHC-null sperm.
    5. part of a complex involved in ATP homeostasis in sperm
      Title: Lactate dehydrogenase C and energy metabolism in mouse sperm.
    6. required for sperm to accomplish fertilization
      Title: LDHC: the ultimate testis-specific gene.
    7. LDHC plays an essential role in maintenance of the processes of glycolysis and ATP production in the flagellum that are required for male fertility and sperm function.
      Title: Expression of the gene for mouse lactate dehydrogenase C (Ldhc) is required for male fertility.
    8. Simultaneous occupancy of the GC box and CRE sites in the core promoter is necessary for full expression of Ldhc in the testis.
      Title: Regulation of murine lactate dehydrogenase C (Ldhc) gene expression.
    9. beta-agonists increased serum LDH levels, but it was not due to release from the heart.
      Title: Beta-agonists enhance the lactic dehydrogenase (LDH) expression in serum and ventricular myocytes of mice.
    10. The high level of LDH-C(4) in postmeiotic cells results from mRNA and protein stability.
      Title: A transgenic analysis of mouse lactate dehydrogenase C promoter activity in the testis.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables L-lactate dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-lactate dehydrogenase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within ATP biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within flagellated sperm motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lactate biosynthetic process from pyruvate IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in lactate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within lactate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in pyruvate catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pyruvate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within pyruvate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in motile cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    L-lactate dehydrogenase C chain
    Names
    LDH testis subunit
    LDH-C
    lactate dehydrogenase 3, C chain, sperm specific
    lactate dehydrogenase-X
    NP_001355290.1
    NP_001355291.1
    NP_038608.1
    XP_006540742.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368361.1 → NP_001355290.1  L-lactate dehydrogenase C chain

      Status: VALIDATED

      Source sequence(s)
      AC090123
      Consensus CDS
      CCDS21290.1
      UniProtKB/Swiss-Prot
      P00342
      UniProtKB/TrEMBL
      Q548Z6, Q64483
      Conserved Domains (1) summary
      cd05293
      Location:19 → 329
      LDH_1; A subgroup of L-lactate dehydrogenases

    2. NM_001368362.1 → NP_001355291.1  L-lactate dehydrogenase C chain

      Status: VALIDATED

      Source sequence(s)
      AC090123
      Consensus CDS
      CCDS21290.1
      UniProtKB/Swiss-Prot
      P00342
      UniProtKB/TrEMBL
      Q548Z6, Q64483
      Conserved Domains (1) summary
      cd05293
      Location:19 → 329
      LDH_1; A subgroup of L-lactate dehydrogenases

    3. NM_013580.4 → NP_038608.1  L-lactate dehydrogenase C chain

      See identical proteins and their annotated locations for NP_038608.1

      Status: VALIDATED

      Source sequence(s)
      AC090123
      Consensus CDS
      CCDS21290.1
      UniProtKB/Swiss-Prot
      P00342
      UniProtKB/TrEMBL
      Q548Z6, Q64483
      Related
      ENSMUSP00000014545.5, ENSMUST00000014545.11
      Conserved Domains (1) summary
      cd05293
      Location:19 → 329
      LDH_1; A subgroup of L-lactate dehydrogenases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      46510687..46527571
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540679.1 → XP_006540742.1  L-lactate dehydrogenase C chain isoform X1

      See identical proteins and their annotated locations for XP_006540742.1

      UniProtKB/Swiss-Prot
      P00342
      UniProtKB/TrEMBL
      Q548Z6, Q64483
      Conserved Domains (1) summary
      cd05293
      Location:19 → 329
      LDH_1; A subgroup of L-lactate dehydrogenases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P00342.2 GenPept UniProtKB/Swiss-Prot:P00342

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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