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    Zfp715 zinc finger protein 715 [ Mus musculus (house mouse) ]

    Gene ID: 69930, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp715provided by MGI
    Official Full Name
    zinc finger protein 715provided by MGI
    Primary source
    MGI:MGI:1917180
    See related
    Ensembl:ENSMUSG00000012640 AllianceGenome:MGI:1917180
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mszf15; 2610041B18Rik
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleolus. Is expressed in central nervous system and genitourinary system. Orthologous to human ZNF175 (zinc finger protein 175). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Zfp715 in Genome Data Viewer
    Location:
    7 B3; 7 28.25 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (42945946..42962724, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (43296522..43313300, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_18760 Neighboring gene expressed sequence EU599041 Neighboring gene STARR-seq mESC enhancer starr_18761 Neighboring gene STARR-seq mESC enhancer starr_18763 Neighboring gene predicted gene, 35588 Neighboring gene STARR-positive B cell enhancer ABC_E4922 Neighboring gene STARR-seq mESC enhancer starr_18769 Neighboring gene STARR-seq mESC enhancer starr_18772 Neighboring gene sialic acid binding Ig-like lectin F Neighboring gene STARR-positive B cell enhancer mm9_chr7:50633698-50633999 Neighboring gene sialic acid binding Ig-like lectin G

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR. Agata Y, et al. Gene, 1998 Jun 15. PMID 9630514
    2. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    3. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 715

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357811.1 → NP_001344740.1  zinc finger protein 715

      Status: VALIDATED

      Source sequence(s)
      AC123045, AC149091
      Consensus CDS
      CCDS39928.1
      UniProtKB/TrEMBL
      G3X9T1
      Conserved Domains (3) summary
      smart00349
      Location:48 → 105
      KRAB; krueppel associated box
      COG5048
      Location:410 → 849
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:442 → 462
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001357812.1 → NP_001344741.1  zinc finger protein 715

      Status: VALIDATED

      Source sequence(s)
      AC123045, AC149091
      Consensus CDS
      CCDS39928.1
      UniProtKB/TrEMBL
      G3X9T1
      Conserved Domains (3) summary
      smart00349
      Location:48 → 105
      KRAB; krueppel associated box
      COG5048
      Location:410 → 849
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:442 → 462
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_027264.4 → NP_081540.3  zinc finger protein 715

      See identical proteins and their annotated locations for NP_081540.3

      Status: VALIDATED

      Source sequence(s)
      AC123045, AC149091
      Consensus CDS
      CCDS39928.1
      UniProtKB/TrEMBL
      G3X9T1
      Related
      ENSMUSP00000103620.3, ENSMUST00000107986.9
      Conserved Domains (3) summary
      smart00349
      Location:48 → 105
      KRAB; krueppel associated box
      COG5048
      Location:410 → 849
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:442 → 462
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      42945946..42962724 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242977.2 → XP_030098837.1  zinc finger protein 715 isoform X2

      Conserved Domains (3) summary
      COG5048
      Location:378 → 817
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:410 → 430
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:48 → 87
      KRAB; KRAB box

    2. XM_030242976.2 → XP_030098836.1  zinc finger protein 715 isoform X1

      UniProtKB/TrEMBL
      G3X9T1
      Conserved Domains (3) summary
      smart00349
      Location:48 → 105
      KRAB; krueppel associated box
      COG5048
      Location:410 → 849
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:442 → 462
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. XM_036153428.1 → XP_036009321.1  zinc finger protein 715 isoform X2

      Conserved Domains (3) summary
      COG5048
      Location:378 → 817
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:410 → 430
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:48 → 87
      KRAB; KRAB box

    4. XM_006541185.5 → XP_006541248.1  zinc finger protein 715 isoform X1

      See identical proteins and their annotated locations for XP_006541248.1

      UniProtKB/TrEMBL
      G3X9T1
      Conserved Domains (3) summary
      smart00349
      Location:48 → 105
      KRAB; krueppel associated box
      COG5048
      Location:410 → 849
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:442 → 462
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. XM_006541183.1 → XP_006541246.1  zinc finger protein 715 isoform X1

      See identical proteins and their annotated locations for XP_006541246.1

      UniProtKB/TrEMBL
      G3X9T1
      Related
      ENSMUSP00000040282.8, ENSMUST00000048015.14
      Conserved Domains (3) summary
      smart00349
      Location:48 → 105
      KRAB; krueppel associated box
      COG5048
      Location:410 → 849
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:442 → 462
      ZF_C2H2; C2H2 Zn finger [structural motif]

    6. XM_006541182.1 → XP_006541245.1  zinc finger protein 715 isoform X1

      See identical proteins and their annotated locations for XP_006541245.1

      UniProtKB/TrEMBL
      G3X9T1
      Conserved Domains (3) summary
      smart00349
      Location:48 → 105
      KRAB; krueppel associated box
      COG5048
      Location:410 → 849
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:442 → 462
      ZF_C2H2; C2H2 Zn finger [structural motif]

    7. XM_036153427.1 → XP_036009320.1  zinc finger protein 715 isoform X2

      Conserved Domains (3) summary
      COG5048
      Location:378 → 817
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:410 → 430
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:48 → 87
      KRAB; KRAB box
    Nucleotide Protein Strain
    Heading Accession and Version

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