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    Apoh apolipoprotein H [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287774, updated on 27-Nov-2024

    Summary

    Official Symbol
    Apohprovided by RGD
    Official Full Name
    apolipoprotein Hprovided by RGD
    Primary source
    RGD:1310625
    See related
    EnsemblRapid:ENSRNOG00000003566 AllianceGenome:RGD:1310625
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables lipid binding activity. Involved in several processes, including negative regulation of respiratory burst; positive regulation of triglyceride catabolic process; and triglyceride transport. Located in cell surface and extracellular space. Used to study myocardial infarction and thrombosis. Human ortholog(s) of this gene implicated in antiphospholipid syndrome; myocardial infarction; and peripheral vascular disease. Orthologous to human APOH (apolipoprotein H). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 20360.3) See more
    Orthologs
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    Genomic context

    See Apoh in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (93841992..93855897)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (93342435..93356334)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (96640013..96653939)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene calcium voltage-gated channel auxiliary subunit gamma 5 Neighboring gene protein kinase C, alpha Neighboring gene centrosomal protein 112 Neighboring gene uncharacterized LOC134480891 Neighboring gene uncharacterized LOC120095198

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables heparin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lipid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables lipid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lipoprotein lipase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables lipoprotein lipase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phospholipid binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in animal organ regeneration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in blood coagulation, intrinsic pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in blood coagulation, intrinsic pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of blood coagulation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of blood coagulation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of endothelial cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of endothelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of fibrinolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of fibrinolysis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of myeloid cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of myeloid cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of respiratory burst IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of smooth muscle cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of smooth muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in plasminogen activation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in plasminogen activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of lipoprotein lipase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of triglyceride catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of blood coagulation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of fibrinolysis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to triglyceride IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in triglyceride metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in triglyceride metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in triglyceride transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    part_of chylomicron IEA
    Inferred from Electronic Annotation
    more info
     
    part_of chylomicron ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    part_of high-density lipoprotein particle IEA
    Inferred from Electronic Annotation
    more info
     
    part_of high-density lipoprotein particle ISO
    Inferred from Sequence Orthology
    more info
     
    part_of very-low-density lipoprotein particle IEA
    Inferred from Electronic Annotation
    more info
     
    part_of very-low-density lipoprotein particle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    beta-2-glycoprotein 1
    Names
    B2GPI
    apo-H
    beta(2)GPI
    beta-2-glycoprotein I

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009626.1NP_001009626.1  beta-2-glycoprotein 1 precursor

      See identical proteins and their annotated locations for NP_001009626.1

      Status: PROVISIONAL

      Source sequence(s)
      BC088180
      UniProtKB/Swiss-Prot
      P26644
      UniProtKB/TrEMBL
      A6HK92, F7FC04, Q5I0M1
      Related
      ENSRNOP00000107954.1, ENSRNOT00000151332.1
      Conserved Domains (2) summary
      PHA02927
      Location:41260
      PHA02927; secreted complement-binding protein; Provisional
      pfam09014
      Location:261345
      Sushi_2; Beta-2-glycoprotein-1 fifth domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      93841992..93855897
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)