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    Cep44 centrosomal protein 44 [ Mus musculus (house mouse) ]

    Gene ID: 382010, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cep44provided by MGI
    Official Full Name
    centrosomal protein 44provided by MGI
    Primary source
    MGI:MGI:3525111
    See related
    Ensembl:ENSMUSG00000038215 AllianceGenome:MGI:3525111
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1712; 4933440G23Rik
    Summary
    Predicted to enable microtubule binding activity. Predicted to be involved in centriole replication and centriole-centriole cohesion. Predicted to be located in centriole. Predicted to be active in centrosome and spindle pole. Orthologous to human CEP44 (centrosomal protein 44). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 7.2), testis adult (RPKM 5.7) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cep44 in Genome Data Viewer
    Location:
    8 B2; 8 29.7 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (56983516..57010052, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (56531516..56550876, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930518J21 gene Neighboring gene STARR-seq mESC enhancer starr_21518 Neighboring gene predicted gene, 24375 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:59029623-59029732 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:59030027-59030210 Neighboring gene STARR-positive B cell enhancer mm9_chr8:59030212-59030513 Neighboring gene F-box protein 8 Neighboring gene ferritin light chain 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_21519 Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Hein MY, et al. Cell, 2015 Oct 22. PMID 26496610
    2. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    3. Functional annotation of a full-length mouse cDNA collection. Kawai J, et al. Nature, 2001 Feb 8. PMID 11217851
    4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, et al. Nature, 2002 Dec 5. PMID 12466851
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • KIAA1712, MGC113766

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in centriole replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in centriole replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in centriole replication ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in centriole-centriole cohesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in centriole-centriole cohesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in centriole-centriole cohesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in centrosome cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in centrosome cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centriole ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in midbody IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle pole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle pole ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    centrosomal protein of 44 kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009951.1 → NP_001009951.1  centrosomal protein of 44 kDa

      See identical proteins and their annotated locations for NP_001009951.1

      Status: PROVISIONAL

      Source sequence(s)
      BC088983
      Consensus CDS
      CCDS22313.1
      UniProtKB/Swiss-Prot
      Q5DTV5, Q5HZK1
      UniProtKB/TrEMBL
      F7BA57
      Related
      ENSMUSP00000042586.9, ENSMUST00000040330.15
      Conserved Domains (1) summary
      pfam15007
      Location:5 → 128
      CEP44; Centrosomal spindle body, CEP44

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      56983516..57010052 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509448.5 → XP_006509511.1  centrosomal protein of 44 kDa isoform X1

      See identical proteins and their annotated locations for XP_006509511.1

      UniProtKB/Swiss-Prot
      Q5DTV5, Q5HZK1
      UniProtKB/TrEMBL
      F7BA57
      Conserved Domains (1) summary
      pfam15007
      Location:5 → 128
      CEP44; Centrosomal spindle body, CEP44

    2. XM_006509447.5 → XP_006509510.1  centrosomal protein of 44 kDa isoform X1

      See identical proteins and their annotated locations for XP_006509510.1

      UniProtKB/Swiss-Prot
      Q5DTV5, Q5HZK1
      UniProtKB/TrEMBL
      F7BA57
      Conserved Domains (1) summary
      pfam15007
      Location:5 → 128
      CEP44; Centrosomal spindle body, CEP44

    3. XM_006509445.5 → XP_006509508.1  centrosomal protein of 44 kDa isoform X1

      See identical proteins and their annotated locations for XP_006509508.1

      UniProtKB/Swiss-Prot
      Q5DTV5, Q5HZK1
      UniProtKB/TrEMBL
      F7BA57
      Conserved Domains (1) summary
      pfam15007
      Location:5 → 128
      CEP44; Centrosomal spindle body, CEP44

    4. XM_006509446.4 → XP_006509509.1  centrosomal protein of 44 kDa isoform X1

      See identical proteins and their annotated locations for XP_006509509.1

      UniProtKB/Swiss-Prot
      Q5DTV5, Q5HZK1
      UniProtKB/TrEMBL
      F7BA57
      Conserved Domains (1) summary
      pfam15007
      Location:5 → 128
      CEP44; Centrosomal spindle body, CEP44

    5. XM_006509450.4 → XP_006509513.1  centrosomal protein of 44 kDa isoform X1

      See identical proteins and their annotated locations for XP_006509513.1

      UniProtKB/Swiss-Prot
      Q5DTV5, Q5HZK1
      UniProtKB/TrEMBL
      F7BA57
      Conserved Domains (1) summary
      pfam15007
      Location:5 → 128
      CEP44; Centrosomal spindle body, CEP44

    6. XM_006509451.5 → XP_006509514.1  centrosomal protein of 44 kDa isoform X1

      See identical proteins and their annotated locations for XP_006509514.1

      UniProtKB/Swiss-Prot
      Q5DTV5, Q5HZK1
      UniProtKB/TrEMBL
      F7BA57
      Conserved Domains (1) summary
      pfam15007
      Location:5 → 128
      CEP44; Centrosomal spindle body, CEP44

    7. XM_006509449.4 → XP_006509512.1  centrosomal protein of 44 kDa isoform X1

      See identical proteins and their annotated locations for XP_006509512.1

      UniProtKB/Swiss-Prot
      Q5DTV5, Q5HZK1
      UniProtKB/TrEMBL
      F7BA57
      Conserved Domains (1) summary
      pfam15007
      Location:5 → 128
      CEP44; Centrosomal spindle body, CEP44

    8. XM_036154140.1 → XP_036010033.1  centrosomal protein of 44 kDa isoform X1

      UniProtKB/Swiss-Prot
      Q5DTV5, Q5HZK1
      UniProtKB/TrEMBL
      F7BA57
      Conserved Domains (1) summary
      pfam15007
      Location:5 → 128
      CEP44; Centrosomal spindle body, CEP44

    9. XM_006509452.4 → XP_006509515.1  centrosomal protein of 44 kDa isoform X1

      See identical proteins and their annotated locations for XP_006509515.1

      UniProtKB/Swiss-Prot
      Q5DTV5, Q5HZK1
      UniProtKB/TrEMBL
      F7BA57
      Conserved Domains (1) summary
      pfam15007
      Location:5 → 128
      CEP44; Centrosomal spindle body, CEP44

    10. XM_017312870.2 → XP_017168359.1  centrosomal protein of 44 kDa isoform X1

      UniProtKB/Swiss-Prot
      Q5DTV5, Q5HZK1
      UniProtKB/TrEMBL
      F7BA57
      Conserved Domains (1) summary
      pfam15007
      Location:5 → 128
      CEP44; Centrosomal spindle body, CEP44

    RNA

    1. XR_004934849.1 RNA Sequence

    2. XR_004934848.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5HZK1.1 GenPept UniProtKB/Swiss-Prot:Q5HZK1

    Gene LinkOut

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