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    Lrg1 leucine-rich alpha-2-glycoprotein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 367455, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lrg1provided by RGD
    Official Full Name
    leucine-rich alpha-2-glycoprotein 1provided by RGD
    Primary source
    RGD:1359464
    See related
    AllianceGenome:RGD:1359464
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including potassium channel activator activity; transforming growth factor beta receptor binding activity; and transmembrane transporter binding activity. Predicted to be involved in positive regulation of epithelial to mesenchymal transition. Predicted to act upstream of or within several processes, including brown fat cell differentiation; positive regulation of transforming growth factor beta receptor signaling pathway; and wound healing, spreading of epidermal cells. Predicted to be located in extracellular space and intracellular membrane-bounded organelle. Predicted to be part of voltage-gated potassium channel complex. Orthologous to human LRG1 (leucine rich alpha-2-glycoprotein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 179.8), Lung (RPKM 55.1) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lrg1 in Genome Data Viewer
    Location:
    9q11
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (1034691..1036937, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (947516..949773, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (10952424..10954664)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene HDGF like 2 Neighboring gene perilipin 4 Neighboring gene perilipin 5 Neighboring gene semaphorin 6B Neighboring gene TNF alpha induced protein 8 like 1 Neighboring gene myeloid-derived growth factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. MicroRNA-497 elevation or LRG1 knockdown promotes osteoblast proliferation and collagen synthesis in osteoporosis via TGF-β1/Smads signalling pathway. Gu Z, et al. J Cell Mol Med, 2020 Nov. PMID 32975015, Free PMC Article
    2. Alterations in glucose concentrations affect DNA methylation at Lrg1 in an ex vivo rat cortical slice model of preterm brain injury. Cartier J, et al. Eur J Neurosci, 2018 Mar. PMID 29356143
    3. LRG1 promotes angiogenesis through upregulating the TGF‑β1 pathway in ischemic rat brain. Meng H, et al. Mol Med Rep, 2016 Dec. PMID 27840991, Free PMC Article
    4. Molecular characterization and expression analysis of leucine-rich alpha2-glycoprotein, a novel marker of granulocytic differentiation. O'Donnell LC, et al. J Leukoc Biol, 2002 Sep. PMID 12223515
    5. Prolyl 3-hydroxylase 1 null mice display abnormalities in fibrillar collagen-rich tissues such as tendons, skin, and bones. Vranka JA, et al. J Biol Chem, 2010 May 28. PMID 20363744, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MicroRNA-497 elevation or LRG1 knockdown promotes osteoblast proliferation and collagen synthesis in osteoporosis via TGF-beta1/Smads signalling pathway.
      Title: MicroRNA-497 elevation or LRG1 knockdown promotes osteoblast proliferation and collagen synthesis in osteoporosis via TGF-β1/Smads signalling pathway.
    2. Culture of slices in lower glucose concentration was associated with lower Lrg1 methylation
      Title: Alterations in glucose concentrations affect DNA methylation at Lrg1 in an ex vivo rat cortical slice model of preterm brain injury.
    3. LRG1 may promote angiogenesis through upregulating the TGFbeta1 signaling pathway in ischemic rat brain following MCAO.
      Title: LRG1 promotes angiogenesis through upregulating the TGF‑β1 pathway in ischemic rat brain.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC95065

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables potassium channel activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transforming growth factor beta receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane transporter binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables type I transforming growth factor beta receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables type II transforming growth factor beta receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables voltage-gated potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within brown fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of keratinocyte migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of leukocyte adhesion to vascular endothelial cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of positive regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of positive regulation of epithelial cell proliferation involved in wound healing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of positive regulation of keratinocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within wound healing, spreading of epidermal cells ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich alpha-2-glycoprotein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009717.1 → NP_001009717.1  leucine-rich alpha-2-glycoprotein precursor

      See identical proteins and their annotated locations for NP_001009717.1

      Status: PROVISIONAL

      Source sequence(s)
      BC088434
      UniProtKB/TrEMBL
      M0R8H5, Q5I0E1
      Conserved Domains (4) summary
      smart00082
      Location:282 → 328
      LRRCT; Leucine rich repeat C-terminal domain
      cd00116
      Location:23 → 284
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:55 → 76
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:75 → 135
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      1034691..1036937 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039084024.2 → XP_038939952.1  leucine-rich alpha-2-glycoprotein isoform X1

      UniProtKB/TrEMBL
      A6KQZ8, M0R8H5
      Conserved Domains (3) summary
      PRK15370
      Location:55 → 293
      PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
      TIGR00864
      Location:259 → 339
      PCC; polycystin cation channel protein
      sd00033
      Location:65 → 86
      LRR_RI; leucine-rich repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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