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    SUPT20HL1 SUPT20H like 1 [ Homo sapiens (human) ]

    Gene ID: 100130302, updated on 10-Dec-2024

    Summary

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    Official Symbol
    SUPT20HL1provided by HGNC
    Official Full Name
    SUPT20H like 1provided by HGNC
    Primary source
    HGNC:HGNC:30773
    See related
    Ensembl:ENSG00000223731 AllianceGenome:HGNC:30773
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SPT20L; FAM48B1
    Summary
    Predicted to enable transcription coregulator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be part of SAGA complex. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See SUPT20HL1 in Genome Data Viewer
    Location:
    Xp22.11
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (24360639..24367839)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (23944797..23952006)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (24378756..24385956)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29499 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:24167489-24168302 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20717 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29500 Neighboring gene ZFX antisense RNA 1 Neighboring gene zinc finger protein X-linked Neighboring gene CRISPRi-validated cis-regulatory element chrX.477 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29501 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29502 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29503 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29504 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20718 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:24328768-24329520 Neighboring gene SUPT20H like 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:24382719-24383459 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chrX:24389623-24390398 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:24394111-24394637 Neighboring gene NANOG hESC enhancer GRCh37_chrX:24428490-24429048 Neighboring gene ribosomal protein S26 pseudogene 58 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20719 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:24509351-24510314 Neighboring gene pyruvate dehydrogenase kinase 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29505 Neighboring gene SNRPE pseudogene 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The human SPT20-containing SAGA complex plays a direct role in the regulation of endoplasmic reticulum stress-induced genes. Nagy Z, et al. Mol Cell Biol, 2009 Mar. PMID 19114550, Free PMC Article
    2. The DNA sequence of the human X chromosome. Ross MT, et al. Nature, 2005 Mar 17. PMID 15772651, Free PMC Article
    3. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. Bennett EJ, et al. Cell, 2010 Dec 10. PMID 21145461, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of SAGA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transcription factor SPT20 homolog-like 1
    Names
    SPT20 homolog, SAGA complex component like 1
    family with sequence similarity 48, member B1
    suppressor of Ty 20 homolog-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136234.3 → NP_001129706.3  transcription factor SPT20 homolog-like 1

      Status: VALIDATED

      Source sequence(s)
      AC004552
      Consensus CDS
      CCDS94581.1
      UniProtKB/Swiss-Prot
      Q3ZLR7
      UniProtKB/TrEMBL
      A0A7I2YQ69
      Related
      ENSP00000509731.1, ENST00000686983.1
      Conserved Domains (2) summary
      PHA03247
      Location:381 → 764
      PHA03247; large tegument protein UL36; Provisional
      pfam12090
      Location:64 → 217
      Spt20; Spt20 family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      24360639..24367839
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      23944797..23952006
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3ZLR7.2 GenPept UniProtKB/Swiss-Prot:Q3ZLR7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials