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    CDK1 cyclin dependent kinase 1 [ Homo sapiens (human) ]

    Gene ID: 983, updated on 10-Dec-2024

    Summary

    Official Symbol
    CDK1provided by HGNC
    Official Full Name
    cyclin dependent kinase 1provided by HGNC
    Primary source
    HGNC:HGNC:1722
    See related
    Ensembl:ENSG00000170312 MIM:116940; AllianceGenome:HGNC:1722
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CDC2; CDC28A; P34CDC2
    Summary
    The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2023]
    Expression
    Broad expression in lymph node (RPKM 12.8), bone marrow (RPKM 12.8) and 18 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CDK1 in Genome Data Viewer
    Location:
    10q21.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (60778331..60794852)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (61635069..61651590)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (62538089..62554610)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ankyrin 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2389 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:62495900-62496400 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:62496401-62496901 Neighboring gene ARF like GTPase 4A pseudogene 1 Neighboring gene ANK3 divergent transcript Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr10:62629619-62630120 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr10:62630121-62630620 Neighboring gene uncharacterized LOC124902432 Neighboring gene Rho related BTB domain containing 1 Neighboring gene RNA, U2 small nuclear 72, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide association study for reading and language abilities in two population cohorts.
    EBI GWAS Catalog
    Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env In cultured neurons, HIV-1 gp120 increases transcription factor E2F1 levels in the nucleus, stimulates its transcriptional activity, and enhances the expression of the E2F1 target proteins Cdc2 and Puma PubMed
    env Cell-cell contact between T cells expressing HIV-1 gp120/gp41 and other T cells expressing CD4 receptors leads to the rapid accumulation of cyclin B and tyrosine-hyperphosphorylated p34cdc2 (cdk1) kinase, indicative of cell cycle arrest at G2 phase PubMed
    Pr55(Gag) gag The amplified luminescent proximity homogeneous assay (AlphaScreen) identifies the interaction of HIV-1 Gag with CDC2 PubMed
    Rev rev cdc2 has been shown to phosphorylate Rev in vitro PubMed
    Tat tat When expressed in astrocytes, neurons, and non-glial 293T cells, HIV-1 Tat interacts with a number of cell cycle-related proteins including cyclin A, cyclin B, cyclin D3, Cdk2, Cdk4, Cdk1/Cdc2, cdc6, p27, p53, p63, hdlg, and PCNA PubMed
    tat Cdc2 activity is enhanced by HIV-1 Tat expression in Jurkat T cells and is associated with Tat-induced apoptosis PubMed
    Vif vif HIV-1 Vif-mediated G2 arrest involves the dysregulation of DK1-CyclinB1 nuclear translocation PubMed
    vif HIV-1 Vif inhibits CDK1 activation and subsequent nuclear translocation PubMed
    Vpr vpr HIV-1 Vpr inactivates the cdc2-cyclin B kinase complex by inhibiting the dephosphorylation of cdc2 tyrosine 15, leading to arrest in the G2 phase of the cell cycle PubMed
    vpr HIV-1 Vpr causes increased levels of CyclinB1, Plk1, and Cdk1 in a complex with the nuclear transport and spindle assembly protein, importin beta PubMed
    vpr Vpr-induced cell cycle G2/M arrest reveals a dramatic increase in the amount of Cdk1, Cdc25C, and CyclinB1 bound to 14-3-3 theta PubMed
    vpr The human Vpr interacting protein (hVIP/MOV34) is a likely cellular cofactor for HIV-1 Vpr inactivation of the cdc2-cyclin B kinase complex and induction of cell cycle arrest PubMed
    vpr Data suggests that HIV-1 Vpr transactivation of the HIV-LTR promoter occurs through the inhibition of p300-associated cdc2-cyclin B kinase complex activity which enhances transcriptional activation by Rel A and p300 PubMed
    vpr Accumulation of the hypophosphorylated or active form of cdc2 kinase is not required for HIV-1 Vpr-induced apoptosis, however one report indicates cdc2 is activated in Vpr-induced apoptotic cells PubMed
    vpr Inactivation of the cdc2-cyclin B kinase complex by HIV-1 Vpr leads to the activation of Poly(A) polymerase PubMed
    vpr Inactivation of the cdc2-cyclin B kinase complex and arrest in the G2 phase of the cell cycle has been mapped to the C-terminus of HIV-1 Vpr, including amino acids 73, 80 and 84-96 PubMed
    vpr HIV-1 Vpr inactivates the cdc2-cyclin B kinase complex by inactivating cdc25C, the phosphatase that dephosphorylates and activates cdc2 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC111195, DKFZp686L20222

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables Hsp70 protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat S2 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat S5 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat S7 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat T4 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat Y1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cyclin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cyclin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables cyclin-dependent protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cyclin-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cyclin-dependent protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cyclin-dependent protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables cyclin-dependent protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
     
    enables histone kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
     
    enables virus receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in DNA damage response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in DNA repair TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in DNA replication TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in ERK1 and ERK2 cascade TAS
    Traceable Author Statement
    more info
     
    involved_in G1/S transition of mitotic cell cycle NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in G2/M transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in G2/M transition of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in G2/M transition of mitotic cell cycle NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in G2/M transition of mitotic cell cycle TAS
    Traceable Author Statement
    more info
     
    involved_in Golgi disassembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in animal organ regeneration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell migration TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cellular response to hydrogen peroxide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to organic cyclic compound IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in centrosome cycle TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromosome condensation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in epithelial cell differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in fibroblast proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in microtubule cytoskeleton organization TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in microtubule cytoskeleton organization involved in mitosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in mitotic G2 DNA damage checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitotic nuclear membrane disassembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in peptidyl-threonine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in peptidyl-threonine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of DNA replication IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of G2/M transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cardiac muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of mitochondrial ATP synthesis coupled electron transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of mitotic sister chromatid segregation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein localization to nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in pronuclear fusion TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in protein deubiquitination TAS
    Traceable Author Statement
    more info
     
    involved_in protein localization to kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein localization to kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein-containing complex assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of Schwann cell differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of attachment of mitotic spindle microtubules to kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of embryonic development TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to amine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to axon injury IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to cadmium ion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to copper ion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to toxic substance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in symbiont entry into host cell IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ventricular cardiac muscle cell development IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromosome, telomeric region HDA PubMed 
    part_of cyclin A1-CDK1 complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of cyclin A2-CDK1 complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of cyclin B1-CDK1 complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    part_of cyclin B1-CDK1 complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of cyclin-dependent protein kinase holoenzyme complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in membrane HDA PubMed 
    located_in midbody IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in mitotic spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in spindle microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    cyclin-dependent kinase 1
    Names
    cell cycle controller CDC2
    cell division control protein 2 homolog
    cell division cycle 2, G1 to S and G2 to M
    cell division protein kinase 1
    p34 protein kinase
    NP_001163877.1
    NP_001163878.1
    NP_001307847.1
    NP_001777.1
    NP_203698.1
    XP_005270360.1
    XP_054223227.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029877.1 RefSeqGene

      Range
      5148..21522
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001170406.1NP_001163877.1  cyclin-dependent kinase 1 isoform 4

      See identical proteins and their annotated locations for NP_001163877.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (4) has a distinct C-terminus and is shorter than isoform 1. Both variants 4 and 5 encode the same isoform (4).
      Source sequence(s)
      AA459484, AC022390, AK295741, DA823877
      UniProtKB/TrEMBL
      B7Z3D6
      Related
      ENST00000475504.6
      Conserved Domains (1) summary
      cl21453
      Location:3106
      PKc_like; Protein Kinases, catalytic domain
    2. NM_001170407.2NP_001163878.1  cyclin-dependent kinase 1 isoform 4

      See identical proteins and their annotated locations for NP_001163878.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (4) has a distinct C-terminus and is shorter than isoform 1. Both variants 4 and 5 encode the same isoform (4).
      Source sequence(s)
      AA459484, AC022390, AK295741, BG723076
      UniProtKB/TrEMBL
      B7Z3D6
      Conserved Domains (1) summary
      cl21453
      Location:3106
      PKc_like; Protein Kinases, catalytic domain
    3. NM_001320918.1NP_001307847.1  cyclin-dependent kinase 1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      BC014563, BQ308742, BU633268, DA823877
      Consensus CDS
      CCDS44408.1
      UniProtKB/Swiss-Prot
      A8K7C4, C9J497, O60764, P06493
      UniProtKB/TrEMBL
      A0A024QZK0, A0A024QZP7
      Conserved Domains (1) summary
      cd07861
      Location:3287
      STKc_CDK1_euk; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 1 from higher eukaryotes
    4. NM_001786.5NP_001777.1  cyclin-dependent kinase 1 isoform 1

      See identical proteins and their annotated locations for NP_001777.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC022390, BC107750, BG723076, X05360
      Consensus CDS
      CCDS44408.1
      UniProtKB/Swiss-Prot
      A8K7C4, C9J497, O60764, P06493
      UniProtKB/TrEMBL
      A0A024QZK0, A0A024QZP7
      Related
      ENSP00000378699.3, ENST00000395284.8
      Conserved Domains (1) summary
      cd07861
      Location:3287
      STKc_CDK1_euk; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 1 from higher eukaryotes
    5. NM_033379.5NP_203698.1  cyclin-dependent kinase 1 isoform 2

      See identical proteins and their annotated locations for NP_203698.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2), also known as CDC2 delta T, lacks an alternate in-frame exon in the middle portion of the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC022390, AW976143, BC107750, BG723076, D88357
      Consensus CDS
      CCDS7260.1
      UniProtKB/TrEMBL
      A0A024QZK0, A0A024QZP7
      Related
      ENSP00000325970.4, ENST00000316629.8
      Conserved Domains (1) summary
      cl21453
      Location:3230
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      60778331..60794852
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005270303.4XP_005270360.1  cyclin-dependent kinase 1 isoform X1

      See identical proteins and their annotated locations for XP_005270360.1

      UniProtKB/Swiss-Prot
      A8K7C4, C9J497, O60764, P06493
      UniProtKB/TrEMBL
      A0A024QZK0, A0A024QZP7
      Related
      ENSP00000397973.2, ENST00000448257.6
      Conserved Domains (1) summary
      cd07861
      Location:3287
      STKc_CDK1_euk; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 1 from higher eukaryotes

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      61635069..61651590
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054367252.1XP_054223227.1  cyclin-dependent kinase 1 isoform X1

      UniProtKB/Swiss-Prot
      A8K7C4, C9J497, O60764, P06493
      UniProtKB/TrEMBL
      A0A024QZK0, A0A024QZP7

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001130829.1: Suppressed sequence

      Description
      NM_001130829.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.