Polg DNA polymerase gamma, catalytic subunit [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Polgprovided by RGD
Official Full Name: DNA polymerase gamma, catalytic subunitprovided by RGD
Primary source: RGD:620057
See related: EnsemblRapid:ENSRNOG00000032293 AllianceGenome:RGD:620057
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables DNA-directed DNA polymerase activity. Involved in several processes, including cellular response to glucose stimulus; response to gamma radiation; and response to hyperoxia. Located in terminal bouton. Part of gamma DNA polymerase complex. Used to study Alpers-Huttenlocher syndrome and hepatocellular carcinoma. Biomarker of status epilepticus. Human ortholog(s) of this gene implicated in several diseases, including mitochondrial DNA depletion syndrome (multiple); mitochondrial myopathy (multiple); neurodegenerative disease (multiple); ovarian disease (multiple); and sensory ataxic neuropathy, dysarthria, and ophthalmoparesis. Orthologous to human POLG (DNA polymerase gamma, catalytic subunit). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 288.9), Thymus (RPKM 162.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q31

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (142792119..142808933, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (133382764..133399578, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (141172117..141188893, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The immunolocalization of 8-oxoguanine DNA glycosylase 1 (OGG1) and AP endonuclease 1 (APE1) in the lens and three of the predominant base excision repair (BER) enzymes: OGG1, APE1, and DNA polymerase gamma, were studied.
Title: Expression changes in DNA repair enzymes and mitochondrial DNA damage in aging rat lens.

Submit: New GeneRIF Correction

General gene information

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Markers

MARC_7859-7860:996688105:3 (e-PCR)
- UniSTS:269839

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3'-5' exonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3'-5' exonuclease activity	ISO Inferred from Sequence Orthology more info
enables 5'-deoxyribose-5-phosphate lyase activity	IEA Inferred from Electronic Annotation more info
enables 5'-deoxyribose-5-phosphate lyase activity	ISO Inferred from Sequence Orthology more info
enables 5'-deoxyribose-5-phosphate lyase activity	ISS Inferred from Sequence or Structural Similarity more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-directed DNA polymerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-directed DNA polymerase activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-directed DNA polymerase activity	IEA Inferred from Electronic Annotation more info
enables DNA-directed DNA polymerase activity	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables exonuclease activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protease binding	IEA Inferred from Electronic Annotation more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables single-stranded DNA 3'-5' DNA exonuclease activity	IEA Inferred from Electronic Annotation more info
enables single-stranded DNA 3'-5' DNA exonuclease activity	ISO Inferred from Sequence Orthology more info
enables single-stranded DNA 3'-5' DNA exonuclease activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in DNA biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in DNA replication proofreading	IEA Inferred from Electronic Annotation more info
involved_in DNA replication proofreading	ISO Inferred from Sequence Orthology more info
involved_in DNA replication proofreading	ISS Inferred from Sequence or Structural Similarity more info
involved_in DNA-templated DNA replication	ISO Inferred from Sequence Orthology more info
involved_in base-excision repair	ISO Inferred from Sequence Orthology more info
involved_in base-excision repair	ISS Inferred from Sequence or Structural Similarity more info
involved_in base-excision repair, gap-filling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within base-excision repair, gap-filling	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glucose stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within determination of adult lifespan	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial DNA replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial DNA replication	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitochondrial DNA replication	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial DNA replication	ISO Inferred from Sequence Orthology more info
involved_in response to gamma radiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hyperoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to light stimulus	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
part_of gamma DNA polymerase complex	IDA Inferred from Direct Assay more info	PubMed
part_of gamma DNA polymerase complex	IEA Inferred from Electronic Annotation more info
part_of gamma DNA polymerase complex	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in mitochondrial chromosome	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial chromosome	ISO Inferred from Sequence Orthology more info
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrial nucleoid	ISO Inferred from Sequence Orthology more info
located_in mitochondrial nucleoid	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in terminal bouton	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: DNA polymerase subunit gamma-1

Names: 3'-5' exodeoxyribonuclease; 5'-deoxyribose-phosphate lyase; DNA-directed DNA polymerase gamma; mitochondrial DNA polymerase catalytic subunit; polG-alpha; polymerase (DNA directed), gamma; polymerase (DNA) gamma, catalytic subunit

NP_445980.2

EC 2.7.7.7

XP_008757783.1

EC 2.7.7.7

XP_038948876.1

EC 2.7.7.7

XP_063131998.1

EC 2.7.7.7

XP_063131999.1

EC 2.7.7.7

XP_063132011.1

EC 2.7.7.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053528.2 → NP_445980.2 DNA polymerase subunit gamma-1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

Q9QYV7, Q9QYV8

UniProtKB/TrEMBL

A6JC54

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

142792119..142808933 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039092948.2 → XP_038948876.1 DNA polymerase subunit gamma-1 isoform X3

Conserved Domains (2) summary

pfam18136
Location:104 → 396

DNApol_Exo; DNA mitochondrial polymerase exonuclease domain

cl02626
Location:772 → 1145

DNA_pol_A; Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication
XM_063275941.1 → XP_063132011.1 DNA polymerase subunit gamma-1 isoform X4
XM_008759561.4 → XP_008757783.1 DNA polymerase subunit gamma-1 isoform X1

See identical proteins and their annotated locations for XP_008757783.1

UniProtKB/TrEMBL

A0A8L2QQ69

Related

ENSRNOP00000047900.4, ENSRNOT00000044567.6

Conserved Domains (3) summary

cd08641
Location:772 → 1187

DNA_pol_gammaA; Pol gammaA is a family A polymerase that is responsible for DNA replication and repair in mitochondria

cl02626
Location:413 → 455

DNA_pol_A; Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication

cl10012
Location:248 → 280

DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
XM_063275929.1 → XP_063131999.1 DNA polymerase subunit gamma-1 isoform X2

UniProtKB/Swiss-Prot

Q9QYV7, Q9QYV8

UniProtKB/TrEMBL

A6JC54
XM_063275928.1 → XP_063131998.1 DNA polymerase subunit gamma-1 isoform X1

UniProtKB/TrEMBL

A0A8L2QQ69