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    Akt1s1 AKT1 substrate 1 [ Mus musculus (house mouse) ]

    Gene ID: 67605, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Akt1s1provided by MGI
    Official Full Name
    AKT1 substrate 1provided by MGI
    Primary source
    MGI:MGI:1914855
    See related
    Ensembl:ENSMUSG00000011096 AllianceGenome:MGI:1914855
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lobe; Lobel; PRAS40; 1110012J22Rik
    Summary
    Predicted to enable protein serine/threonine kinase inhibitor activity. Involved in regulation of neuron apoptotic process. Located in cytosol. Is expressed in brain. Orthologous to human AKT1S1 (AKT1 substrate 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 52.6), ovary adult (RPKM 41.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Akt1s1 in Genome Data Viewer
    Location:
    7; 7 B3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44498648..44504845)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (44849224..44855421)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene activating transcription factor 5 Neighboring gene interleukin 4 induced 1B Neighboring gene nucleoporin 62 Neighboring gene STARR-positive B cell enhancer ABC_E9111 Neighboring gene interleukin 4 induced 1 Neighboring gene TBC1 domain family, member 17 Neighboring gene microRNA 707 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:52112565-52112765 Neighboring gene polynucleotide kinase 3'- phosphatase Neighboring gene prostate tumor over expressed gene 1 Neighboring gene mediator complex subunit 25 Neighboring gene STARR-positive B cell enhancer ABC_E8171

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PRAS40 regulates protein synthesis and cell cycle in C2C12 myoblasts. Kazi AA, et al. Mol Med, 2010 Sep-Oct. PMID 20464060, Free PMC Article
    2. Pathological hypertrophy amelioration by PRAS40-mediated inhibition of mTORC1. Völkers M, et al. Proc Natl Acad Sci U S A, 2013 Jul 30. PMID 23842089, Free PMC Article
    3. PRAS40 prevents development of diabetic cardiomyopathy and improves hepatic insulin sensitivity in obesity. Völkers M, et al. EMBO Mol Med, 2014 Jan. PMID 24408966, Free PMC Article
    4. Genetic ablation of PRAS40 improves glucose homeostasis via linking the AKT and mTOR pathways. Malla R, et al. Biochem Pharmacol, 2015 Jul 1. PMID 25931147
    5. PRAS40 alleviates neurotoxic prion peptide-induced apoptosis via mTOR-AKT signaling. Yang W, et al. CNS Neurosci Ther, 2017 May. PMID 28294542, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Stage-specific regulation of undifferentiated spermatogonia by AKT1S1-mediated AKT-mTORC1 signaling during mouse spermatogenesis.
      Title: Stage-specific regulation of undifferentiated spermatogonia by AKT1S1-mediated AKT-mTORC1 signaling during mouse spermatogenesis.
    2. This study, for the first time, links PF4's anti-RNV function to an intracellular signaling molecule PRAS40 and its phosphorylation.
      Title: PF4 antagonizes retinal neovascularization via inhibiting PRAS40 phosphorylation in a mouse model of oxygen-induced retinopathy.
    3. Overexpression of PRAS40(T246A) in the Proliferative Compartment Suppresses mTORC1 Signaling, Keratinocyte Migration, and Skin Tumor Development
      Title: Overexpression of PRAS40(T246A) in the Proliferative Compartment Suppresses mTORC1 Signaling, Keratinocyte Migration, and Skin Tumor Development.
    4. PRAS40 inhibits mTORC1 hyperactivation and plays a key role in protecting cells against neurotoxic prion peptide-induced apoptosis. Thus, PRAS40 is a potential therapeutic target for prion disease.
      Title: PRAS40 alleviates neurotoxic prion peptide-induced apoptosis via mTOR-AKT signaling.
    5. PRAS40 appears to reduce brain injury following ischemic stroke by converting cell signaling from Akt to mTOR
      Title: PRAS40 plays a pivotal role in protecting against stroke by linking the Akt and mTOR pathways.
    6. PRAS40 treatment improves hepatic insulin sensitivity and reduces systemic hyperglycaemia in obese mice.
      Title: PRAS40 prevents development of diabetic cardiomyopathy and improves hepatic insulin sensitivity in obesity.
    7. PRAS40 phosphorylation acts as a molecular switch allowing mTORC1 activation during physiological growth, opening up unique possibilities for therapeutic regulation of the mTORC1 complex to mitigate pathologic myocardial hypertrophy by PRAS40
      Title: Pathological hypertrophy amelioration by PRAS40-mediated inhibition of mTORC1.
    8. Naturally secreted amyloid-beta increases mammalian target of rapamycin (mTOR) activity via a PRAS40-mediated mechanism.
      Title: Naturally secreted amyloid-beta increases mammalian target of rapamycin (mTOR) activity via a PRAS40-mediated mechanism.
    9. These results suggest that a reduction in PRAS40 specifically impairs myoblast protein synthesis, cell cycle, proliferation and differentiation to myotubes.
      Title: PRAS40 regulates protein synthesis and cell cycle in C2C12 myoblasts.
    10. after mTORC1 kinase activation by upstream regulators, PRAS40 is phosphorylated directly by mTOR, thus contributing to the relief of PRAS40-mediated substrate competition.
      Title: Regulation of proline-rich Akt substrate of 40 kDa (PRAS40) function by mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Notch signaling pathway ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    involved_in negative regulation of TOR signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of TORC1 signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of cell size ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neurotrophin TRK receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of neuron apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of TORC1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    proline-rich AKT1 substrate 1
    Names
    AKT1 substrate 1 (proline-rich)
    proline-rich AKT substrate

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001253920.1 → NP_001240849.1  proline-rich AKT1 substrate 1 isoform b

      See identical proteins and their annotated locations for NP_001240849.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) contains an alternate first exon compared to variant 3. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 1 and 2 both encode the same isoform (b).
      Source sequence(s)
      AK141771, BE847693, BY100800
      Consensus CDS
      CCDS21218.1
      UniProtKB/Swiss-Prot
      A2RT52, Q9D1F4
      UniProtKB/TrEMBL
      F6R8S6
      Related
      ENSMUSP00000103512.2, ENSMUST00000107880.9
      Conserved Domains (1) summary
      pfam15798
      Location:128 → 252
      PRAS; Proline-rich AKT1 substrate 1

    2. NM_001290694.1 → NP_001277623.1  proline-rich AKT1 substrate 1 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) encodes the longest isoform (a)
      Source sequence(s)
      AA015487, AK141771, BB618044, BE847693
      Consensus CDS
      CCDS71954.1
      UniProtKB/TrEMBL
      E9QKI5, F6R8S6
      Related
      ENSMUSP00000103514.2, ENSMUST00000107882.8
      Conserved Domains (1) summary
      pfam15798
      Location:154 → 278
      PRAS; Proline-rich AKT1 substrate 1

    3. NM_001290695.1 → NP_001277624.1  proline-rich AKT1 substrate 1 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate exon and uses an alternate first exon compared to variant 3. The resulting isoform (c) has a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AA231178, AK141771, BE847693, W71279
      UniProtKB/Swiss-Prot
      Q9D1F4
      Conserved Domains (1) summary
      pfam15798
      Location:27 → 151
      PRAS; Proline-rich AKT1 substrate 1

    4. NM_001382480.1 → NP_001369409.1  proline-rich AKT1 substrate 1 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC158231
      UniProtKB/Swiss-Prot
      A2RT52, Q9D1F4
      UniProtKB/TrEMBL
      F6R8S6
      Conserved Domains (1) summary
      pfam15798
      Location:128 → 252
      PRAS; Proline-rich AKT1 substrate 1

    5. NM_001382481.1 → NP_001369410.1  proline-rich AKT1 substrate 1 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC158231
      UniProtKB/Swiss-Prot
      A2RT52, Q9D1F4
      UniProtKB/TrEMBL
      F6R8S6
      Conserved Domains (1) summary
      pfam15798
      Location:128 → 252
      PRAS; Proline-rich AKT1 substrate 1

    6. NM_001382482.1 → NP_001369411.1  proline-rich AKT1 substrate 1 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC158231
      UniProtKB/Swiss-Prot
      A2RT52, Q9D1F4
      UniProtKB/TrEMBL
      F6R8S6
      Conserved Domains (1) summary
      pfam15798
      Location:128 → 252
      PRAS; Proline-rich AKT1 substrate 1

    7. NM_001382483.1 → NP_001369412.1  proline-rich AKT1 substrate 1 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC158231
      UniProtKB/Swiss-Prot
      A2RT52, Q9D1F4
      UniProtKB/TrEMBL
      F6R8S6
      Conserved Domains (1) summary
      pfam15798
      Location:128 → 252
      PRAS; Proline-rich AKT1 substrate 1

    8. NM_001382484.1 → NP_001369413.1  proline-rich AKT1 substrate 1 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC158231
      UniProtKB/Swiss-Prot
      A2RT52, Q9D1F4
      UniProtKB/TrEMBL
      F6R8S6
      Conserved Domains (1) summary
      pfam15798
      Location:128 → 252
      PRAS; Proline-rich AKT1 substrate 1

    9. NM_026270.4 → NP_080546.1  proline-rich AKT1 substrate 1 isoform b

      See identical proteins and their annotated locations for NP_080546.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate first exon compared to variant 3. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 1 and 2 both encode the same isoform (b).
      Source sequence(s)
      AK141771, BE847693, BY103589
      Consensus CDS
      CCDS21218.1
      UniProtKB/Swiss-Prot
      A2RT52, Q9D1F4
      UniProtKB/TrEMBL
      F6R8S6
      Related
      ENSMUSP00000049764.9, ENSMUST00000054343.15
      Conserved Domains (1) summary
      pfam15798
      Location:128 → 252
      PRAS; Proline-rich AKT1 substrate 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      44498648..44504845
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242937.2 → XP_030098797.1  proline-rich AKT1 substrate 1 isoform X2

      UniProtKB/Swiss-Prot
      A2RT52, Q9D1F4
      UniProtKB/TrEMBL
      F6R8S6
      Related
      ENSMUSP00000116149.3, ENSMUST00000127783.2
      Conserved Domains (1) summary
      pfam15798
      Location:128 → 252
      PRAS; Proline-rich AKT1 substrate 1

    2. XM_006541117.3 → XP_006541180.1  proline-rich AKT1 substrate 1 isoform X1

      UniProtKB/TrEMBL
      F6R8S6
      Conserved Domains (1) summary
      pfam15798
      Location:135 → 259
      PRAS; Proline-rich AKT1 substrate 1

    3. XM_006541118.5 → XP_006541181.1  proline-rich AKT1 substrate 1 isoform X3

      UniProtKB/TrEMBL
      F6R8S6
      Conserved Domains (1) summary
      pfam15798
      Location:131 → 255
      PRAS; Proline-rich AKT1 substrate 1

    4. XM_036153382.1 → XP_036009275.1  proline-rich AKT1 substrate 1 isoform X2

      UniProtKB/Swiss-Prot
      A2RT52, Q9D1F4
      UniProtKB/TrEMBL
      F6R8S6
      Conserved Domains (1) summary
      pfam15798
      Location:128 → 252
      PRAS; Proline-rich AKT1 substrate 1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D1F4.1 GenPept UniProtKB/Swiss-Prot:Q9D1F4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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