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    Galk2 galactokinase 2 [ Mus musculus (house mouse) ]

    Gene ID: 69976, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Galk2provided by MGI
    Official Full Name
    galactokinase 2provided by MGI
    Primary source
    MGI:MGI:1917226
    See related
    Ensembl:ENSMUSG00000027207 AllianceGenome:MGI:1917226
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gk2; 2810017M24Rik
    Summary
    Predicted to enable galactokinase activity. Predicted to be involved in galactose metabolic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; brain; cardiovascular system; ear; and genitourinary system. Orthologous to human GALK2 (galactokinase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 9.1), kidney adult (RPKM 8.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Galk2 in Genome Data Viewer
    Location:
    2 F1; 2 61.76 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (125701029..125826218)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (125859109..125984298)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene SECIS binding protein 2-like Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:125602741-125602942 Neighboring gene STARR-positive B cell enhancer ABC_E5976 Neighboring gene STARR-positive B cell enhancer ABC_E7857 Neighboring gene STARR-positive B cell enhancer ABC_E11156 Neighboring gene COP9 signalosome subunit 2 Neighboring gene family with sequence similarity 227, member B Neighboring gene fibroblast growth factor 7 Neighboring gene predicted gene, 26496

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The genetic program of hematopoietic stem cells. Phillips RL, et al. Science, 2000 Jun 2. PMID 10834841
    2. Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development. Bulusu V, et al. Dev Cell, 2017 Feb 27. PMID 28245920, Free PMC Article
    3. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (2) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables N-acetylgalactosamine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables galactokinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables galactokinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables galactokinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in galactose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in galactose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    N-acetylgalactosamine kinase
    Names
    galNAc kinase
    NP_001277931.1
    NP_780363.1
    XP_006500216.1
    XP_006500217.1
    XP_011238072.1
    XP_011238074.1
    XP_030107919.1
    XP_030107920.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291002.1 → NP_001277931.1  N-acetylgalactosamine kinase isoform a

      See identical proteins and their annotated locations for NP_001277931.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (a).
      Source sequence(s)
      AK082521, BC079843, BU698705
      Consensus CDS
      CCDS71134.1
      UniProtKB/Swiss-Prot
      Q68FH4
      UniProtKB/TrEMBL
      Q3U3H5
      Related
      ENSMUSP00000092186.3, ENSMUST00000094604.9
      Conserved Domains (3) summary
      PLN02521
      Location:18 → 456
      PLN02521; galactokinase
      pfam08544
      Location:350 → 413
      GHMP_kinases_C; GHMP kinases C terminal
      pfam10509
      Location:24 → 73
      GalKase_gal_bdg; Galactokinase galactose-binding signature

    2. NM_175154.3 → NP_780363.1  N-acetylgalactosamine kinase isoform b

      See identical proteins and their annotated locations for NP_780363.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.
      Source sequence(s)
      AK082521, AL844580
      Consensus CDS
      CCDS16680.1
      UniProtKB/TrEMBL
      Q8BUU7
      Related
      ENSMUSP00000028636.7, ENSMUST00000028636.13
      Conserved Domains (3) summary
      PLN02521
      Location:6 → 445
      PLN02521; galactokinase
      pfam08544
      Location:339 → 402
      GHMP_kinases_C; GHMP kinases C terminal
      pfam10509
      Location:13 → 62
      GalKase_gal_bdg; Galactokinase galactose-binding signature

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      125701029..125826218
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252060.1 → XP_030107920.1  N-acetylgalactosamine kinase isoform X3

      UniProtKB/TrEMBL
      Q8BWB2
      Conserved Domains (1) summary
      PLN02521
      Location:6 → 338
      PLN02521; galactokinase

    2. XM_006500153.5 → XP_006500216.1  N-acetylgalactosamine kinase isoform X1

      See identical proteins and their annotated locations for XP_006500216.1

      UniProtKB/TrEMBL
      Q3U728
      Conserved Domains (1) summary
      PLN02521
      Location:2 → 432
      PLN02521; galactokinase

    3. XM_006500154.3 → XP_006500217.1  N-acetylgalactosamine kinase isoform X2

      UniProtKB/TrEMBL
      Q8BWB2
      Conserved Domains (1) summary
      PLN02521
      Location:18 → 349
      PLN02521; galactokinase

    4. XM_011239770.3 → XP_011238072.1  N-acetylgalactosamine kinase isoform X1

      See identical proteins and their annotated locations for XP_011238072.1

      UniProtKB/TrEMBL
      Q3U728
      Conserved Domains (1) summary
      PLN02521
      Location:2 → 432
      PLN02521; galactokinase

    5. XM_011239772.1 → XP_011238074.1  N-acetylgalactosamine kinase isoform X4

      Conserved Domains (1) summary
      PLN02521
      Location:1 → 268
      PLN02521; galactokinase

    6. XM_030252059.1 → XP_030107919.1  N-acetylgalactosamine kinase isoform X1

      UniProtKB/TrEMBL
      Q3U728
      Conserved Domains (1) summary
      PLN02521
      Location:2 → 432
      PLN02521; galactokinase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q68FH4.1 GenPept UniProtKB/Swiss-Prot:Q68FH4

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