Skp2 S-phase kinase-associated protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Skp2provided by MGI
Official Full Name: S-phase kinase-associated protein 2provided by MGI
Primary source: MGI:MGI:1351663
See related: Ensembl:ENSMUSG00000054115 AllianceGenome:MGI:1351663
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: p45; FWD1; FBXL1; 4930500A04Rik
Summary: Enables ubiquitin-like ligase-substrate adaptor activity. Involved in positive regulation of double-strand break repair via homologous recombination and protein K63-linked ubiquitination. Acts upstream of or within several processes, including mitotic cell cycle phase transition; positive regulation of intracellular estrogen receptor signaling pathway; and positive regulation of protein polyubiquitination. Part of SCF ubiquitin ligase complex. Is expressed in several structures, including blastocyst; brain; compacted morula; and retina nuclear layer. Human ortholog(s) of this gene implicated in prostate carcinoma. Orthologous to human SKP2 (S-phase kinase associated protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in testis adult (RPKM 26.1), limb E14.5 (RPKM 12.8) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 A1; 15 3.84 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (9112070..9155512, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (9111982..9155425, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SKP2 Knockout in Rb1/p53-Deficient Mouse Models of Osteosarcoma Induces Immune Infiltration and Drives a Transcriptional Program with a Favorable Prognosis.
Title: SKP2 Knockout in Rb1/p53-Deficient Mouse Models of Osteosarcoma Induces Immune Infiltration and Drives a Transcriptional Program with a Favorable Prognosis.
A critical role of the endothelial S-phase kinase-associated protein 2/phosphatase and tensin homologue axis in angiogenesis and psoriasis.
Title: A critical role of the endothelial S-phase kinase-associated protein 2/phosphatase and tensin homologue axis in angiogenesis and psoriasis.
Immunosensitivity mediated by downregulated AKT1-SKP2 induces anti-PD-1-associated thyroid immune injury.
Title: Immunosensitivity mediated by downregulated AKT1-SKP2 induces anti-PD-1-associated thyroid immune injury.
AhR activation promotes Treg cell generation by enhancing Lkb1-mediated fatty acid oxidation via the Skp2/K63-ubiquitination pathway.
Title: AhR activation promotes Treg cell generation by enhancing Lkb1-mediated fatty acid oxidation via the Skp2/K63-ubiquitination pathway.
SCF-SKP2 E3 ubiquitin ligase links mTORC1/ER stress/ISR with YAP activation in murine renal cystogenesis.
Title: SCF-SKP2 E3 ubiquitin ligase links mTORC1/ER stress/ISR with YAP activation in murine renal cystogenesis.
The role of SCF(Skp2) and SCF(beta-TrCP1/2) in the cerebellar granule cell precursors.
Title: The role of SCF(Skp2) and SCF(β-TrCP1/2) in the cerebellar granule cell precursors.
S-Phase Kinase-associated Protein-2 Rejuvenates Senescent Endothelial Progenitor Cells and Induces Angiogenesis in Vivo.
Title: S-Phase Kinase-associated Protein-2 Rejuvenates Senescent Endothelial Progenitor Cells and Induces Angiogenesis in Vivo.
MAD2B contributes to parietal epithelial cell activation and crescentic glomerulonephritis via Skp2.
Title: MAD2B contributes to parietal epithelial cell activation and crescentic glomerulonephritis via Skp2.
Skp2 contributes to cell cycle progression in trophoblast stem cells and to placental development.
Title: Skp2 contributes to cell cycle progression in trophoblast stem cells and to placental development.
Therapeutic targeting of the E3 ubiquitin ligase SKP2 in T-ALL.
Title: Therapeutic targeting of the E3 ubiquitin ligase SKP2 in T-ALL.

Submit: New GeneRIF Correction See all GeneRIFs (83)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin-like ligase-substrate adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin-like ligase-substrate adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G1/S transition of mitotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in G2/M transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within G2/M transition of mitotic cell cycle	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within G2/M transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to virus	IEA Inferred from Electronic Annotation more info
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of double-strand break repair via homologous recombination	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of intracellular estrogen receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of protein polyubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein K48-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K48-linked ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein K63-linked ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein K63-linked ubiquitination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein polyubiquitination	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of apoptotic process	ISO Inferred from Sequence Orthology more info	PubMed
involved_in regulation of cell cycle	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of cell cycle	IPI Inferred from Physical Interaction more info	PubMed
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of SCF ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SCF ubiquitin ligase complex	IDA Inferred from Direct Assay more info	PubMed
part_of SCF ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of SCF ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: S-phase kinase-associated protein 2

Names: F-box protein Skp2; F-box/WD-40 protein 1; cyclin A/CDK2-associated protein p45

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001285980.1 → NP_001272909.1 S-phase kinase-associated protein 2 isoform c

See identical proteins and their annotated locations for NP_001272909.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, lacks part of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus, compared to isoform a.

Source sequence(s)

AC139209, AK006221, AK015652, BC092236

Consensus CDS

CCDS79360.1

UniProtKB/TrEMBL

A0A087WQ11

Related

ENSMUSP00000139997.2, ENSMUST00000190131.2

Conserved Domains (3) summary

cd09293
Location:158 → 310

AMN1; Antagonist of mitotic exit network protein 1

sd00034
Location:102 → 132

LRR_AMN1; leucine-rich repeat [structural motif]

pfam12937
Location:62 → 107

F-box-like; F-box-like
NM_013787.3 → NP_038815.1 S-phase kinase-associated protein 2 isoform a

See identical proteins and their annotated locations for NP_038815.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).

Source sequence(s)

AC139209, AK166034, BY740905

Consensus CDS

CCDS37037.1

UniProtKB/Swiss-Prot

Q8BSG7, Q8C8Y9, Q8CB22, Q99J53, Q9Z0Z3

UniProtKB/TrEMBL

Q569Z9

Related

ENSMUSP00000094225.4, ENSMUST00000096482.10

Conserved Domains (3) summary

cd09293
Location:193 → 345

AMN1; Antagonist of mitotic exit network protein 1

sd00034
Location:137 → 167

LRR_AMN1; leucine-rich repeat [structural motif]

pfam12937
Location:97 → 142

F-box-like; F-box-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

9112070..9155512 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011245359.3 → XP_011243661.1 S-phase kinase-associated protein 2 isoform X1

See identical proteins and their annotated locations for XP_011243661.1

Conserved Domains (3) summary

cd09293
Location:203 → 355

AMN1; Antagonist of mitotic exit network protein 1

sd00034
Location:147 → 177

LRR_AMN1; leucine-rich repeat [structural motif]

pfam12937
Location:107 → 151

F-box-like

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_145468.1: Suppressed sequence

Description

NM_145468.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.