Myl6 myosin, light polypeptide 6, alkali, smooth muscle and non-muscle [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Myl6provided by MGI
Official Full Name: myosin, light polypeptide 6, alkali, smooth muscle and non-muscleprovided by MGI
Primary source: MGI:MGI:109318
See related: Ensembl:ENSMUSG00000090841 AllianceGenome:MGI:109318
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: LC17; Myln; ESMLC; MLC-3; MLC1SM; LC17-GI
Summary: Predicted to enable microfilament motor activity. Predicted to be a structural constituent of muscle. Predicted to be involved in muscle filament sliding and skeletal muscle tissue development. Part of unconventional myosin complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and hemolymphoid system gland. Orthologous to human MYL6 (myosin light chain 6). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in bladder adult (RPKM 2188.3), placenta adult (RPKM 580.4) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 D3; 10 76.75 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (128326728..128329755, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (128490859..128493886, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MARC_5817-5818:991939742:3 (e-PCR)
- UniSTS:231174

MARC_5817-5818:997299325:1 (e-PCR)
- UniSTS:231174

Myln (e-PCR), detects polymorphism
- UniSTS:143966

Myln (e-PCR), detects polymorphism
- UniSTS:143967

RH125424 (e-PCR)
- UniSTS:162246

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables cytoskeletal motor activity	TAS Traceable Author Statement more info	PubMed
enables microfilament motor activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of muscle	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of muscle	ISO Inferred from Sequence Orthology more info
enables structural constituent of muscle	ISS Inferred from Sequence or Structural Similarity more info
enables structural constituent of muscle	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in muscle contraction	TAS Traceable Author Statement more info	PubMed
involved_in muscle filament sliding	TAS Traceable Author Statement more info	PubMed
involved_in skeletal muscle tissue development	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in brush border	ISO Inferred from Sequence Orthology more info
part_of myosin II complex	IBA Inferred from Biological aspect of Ancestor more info
part_of myosin complex	TAS Traceable Author Statement more info	PubMed
part_of unconventional myosin complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: myosin light polypeptide 6

Names: 17 kDa myosin light chain; myosin light chain A3; myosin light chain alkali 3; myosin light chain, alkali, nonmuscle; smooth muscle and nonmuscle myosin light chain alkali 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001317217.2 → NP_001304146.1 myosin light polypeptide 6 isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1 and 6 both encode the same isoform (a).

Source sequence(s)

AC170752

Consensus CDS

CCDS88111.1

UniProtKB/TrEMBL

A0A1W2P6F6, A0A1W2P7Q9

Related

ENSMUSP00000151915.2, ENSMUST00000219236.2

Conserved Domains (3) summary

smart00054
Location:11 → 39

EFh; EF-hand, calcium binding motif

cd00051
Location:94 → 144

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cl08302
Location:11 → 75

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
NM_001317218.2 → NP_001304147.1 myosin light polypeptide 6 isoform MLC3nm

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate exon in the 3' coding region, resulting in a framehsift and a novel 3' UTR, compared to variant 1. The encoded isoform (MLC3nm, also known as LC17A and LC17-nm) has a distinct C-terminus and is shorter than isoform a. Isoforms MLC3nm and MLC3sm are the same length but differ in their C-termini.

Source sequence(s)

AC170752

Consensus CDS

CCDS88112.1

UniProtKB/Swiss-Prot

Q60605

UniProtKB/TrEMBL

A0A1W2P6F6

Related

ENSMUSP00000151693.2, ENSMUST00000218127.2

Conserved Domains (1) summary

PTZ00184
Location:5 → 150

PTZ00184; calmodulin; Provisional
NM_001317219.2 → NP_001304148.1 myosin light polypeptide 6 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (4) has multiple differences, compared to variant 1. These differences result in distinct 5' and 3' UTRs, translation initiation at a downstream start codon, and a frameshift, compared to variant 1. The encoded isoform (b) has a shorter N-terminus and a distinct C-terminus, compared to isoform a. Isoforms b and c are the same length but differ in their C-termini. Variants 4 and 11 both encode the same isoform (b).

Source sequence(s)

AC170752

Conserved Domains (1) summary

PTZ00184
Location:1 → 115

PTZ00184; calmodulin; Provisional
NM_001317220.2 → NP_001304149.1 myosin light polypeptide 6 isoform c

Status: VALIDATED

Description

Transcript Variant: This variant (5) has multiple differences, compared to variant 1. These differences result in distinct 5' and 3' UTRs, translation initiation at a downstream start codon, and a frameshift, compared to variant 1. The encoded isoform (c) has a shorter N-terminus and a distinct C-terminus, compared to isoform a. Isoforms b and c are the same length but differ in their C-termini. Variants 5, 9, and 10 all encode the same isoform (c).

Source sequence(s)

AC170752

Conserved Domains (1) summary

PTZ00184
Location:1 → 114

PTZ00184; calmodulin; Provisional
NM_001428663.1 → NP_001415592.1 myosin light polypeptide 6 isoform a

Status: VALIDATED

Source sequence(s)

AC170752

UniProtKB/TrEMBL

A0A1W2P6F6, A0A1W2P7Q9
NM_001428664.1 → NP_001415593.1 myosin light polypeptide 6 isoform d

Status: VALIDATED

Source sequence(s)

AC170752

UniProtKB/TrEMBL

A0A1W2P6F6
NM_001428665.1 → NP_001415594.1 myosin light polypeptide 6 isoform e

Status: VALIDATED

Source sequence(s)

AC170752

UniProtKB/TrEMBL

A0A1W2P6F6, A0A1W2P6G5
NM_001428667.1 → NP_001415596.1 myosin light polypeptide 6 isoform c

Status: VALIDATED

Source sequence(s)

AC170752
NM_001428668.1 → NP_001415597.1 myosin light polypeptide 6 isoform c

Status: VALIDATED

Source sequence(s)

AC170752
NM_001428672.1 → NP_001415601.1 myosin light polypeptide 6 isoform b

Status: VALIDATED

Source sequence(s)

AC170752
NM_001428673.1 → NP_001415602.1 myosin light polypeptide 6 isoform f

Status: VALIDATED

Source sequence(s)

AC170752
NM_001428675.1 → NP_001415604.1 myosin light polypeptide 6 isoform g

Status: VALIDATED

Source sequence(s)

AC170752
NM_001428677.1 → NP_001415606.1 myosin light polypeptide 6 isoform h

Status: VALIDATED

Description

Transcript Variant: This variant (14), as well as variant 15, encodes isoform h.

Source sequence(s)

AC170752
NM_001428678.1 → NP_001415607.1 myosin light polypeptide 6 isoform h

Status: VALIDATED

Source sequence(s)

AC170752
NM_001428679.1 → NP_001415608.1 myosin light polypeptide 6 isoform i

Status: VALIDATED

Source sequence(s)

AC170752
NM_001428680.1 → NP_001415609.1 myosin light polypeptide 6 isoform j

Status: VALIDATED

Source sequence(s)

AC170752
NM_001428681.1 → NP_001415610.1 myosin light polypeptide 6 isoform k

Status: VALIDATED

Source sequence(s)

AC170752
NM_010860.5 → NP_034990.1 myosin light polypeptide 6 isoform MLC3sm

See identical proteins and their annotated locations for NP_034990.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate exon in the 3' coding region, resulting in a frameshift and a novel 3' UTR, compared to variant 1. The encoded isoform (MLC3sm, also known as LC17B and LC17-sm) has a distinct C-terminus and is shorter than isoform a. Isoforms MLC3sm and MLC3nm are the same length but differ in their C-termini. Isoforms b and c are the same length but differ in their C-termini.

Source sequence(s)

AC170752

Consensus CDS

CCDS48728.1

UniProtKB/TrEMBL

A0A1W2P6F6, Q642K0

Related

ENSMUSP00000128803.2, ENSMUST00000164181.2

Conserved Domains (1) summary

PTZ00184
Location:5 → 149

PTZ00184; calmodulin; Provisional

RNA

NR_190456.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC170752
NR_190457.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC170752

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

128326728..128329755 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036155669.1 → XP_036011562.1 myosin light polypeptide 6 isoform X1

Conserved Domains (1) summary

PTZ00184
Location:1 → 114

PTZ00184; calmodulin; Provisional
XM_036155670.1 → XP_036011563.1 myosin light polypeptide 6 isoform X2

Conserved Domains (1) summary

PTZ00184
Location:1 → 115

PTZ00184; calmodulin; Provisional
XM_030244939.2 → XP_030100799.1 myosin light polypeptide 6 isoform X2

Conserved Domains (1) summary

PTZ00184
Location:1 → 115

PTZ00184; calmodulin; Provisional