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    Zdhhc12 zinc finger DHHC-type palmitoyltransferase 12 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 366014, updated on 9-Dec-2024

    Summary

    Official Symbol
    Zdhhc12provided by RGD
    Official Full Name
    zinc finger DHHC-type palmitoyltransferase 12provided by RGD
    Primary source
    RGD:1306593
    See related
    EnsemblRapid:ENSRNOG00000015791 AllianceGenome:RGD:1306593
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in several processes, including gephyrin clustering involved in postsynaptic density assembly; negative regulation of NLRP3 inflammasome complex assembly; and peptidyl-L-cysteine S-palmitoylation. Predicted to be located in Golgi membrane and endoplasmic reticulum membrane. Predicted to be active in Golgi apparatus; dendritic spine; and endoplasmic reticulum. Orthologous to human ZDHHC12 (zinc finger DHHC-type palmitoyltransferase 12). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 131.9), Kidney (RPKM 67.8) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Zdhhc12 in Genome Data Viewer
    Location:
    3p12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (33761338..33764207, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (13363504..13366383, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (8656397..8659102, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene spectrin, alpha, non-erythrocytic 1 Neighboring gene dynein 2 intermediate chain 2 Neighboring gene Set nuclear proto-oncogene Neighboring gene protein kinase N3 Neighboring gene zyg-11 related, cell cycle regulator Neighboring gene TBC1 domain family, member 13

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables palmitoyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-cysteine S-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein-cysteine S-palmitoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-cysteine S-palmitoyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-cysteine S-palmitoyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in gephyrin clustering involved in postsynaptic density assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in gephyrin clustering involved in postsynaptic density assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in gephyrin clustering involved in postsynaptic density assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of NLRP3 inflammasome complex assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of NLRP3 inflammasome complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of NLRP3 inflammasome complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in peptidyl-L-cysteine S-palmitoylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-L-cysteine S-palmitoylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of synaptic transmission, GABAergic IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of synaptic transmission, GABAergic ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of synaptic transmission, GABAergic ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein palmitoylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendritic spine IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    palmitoyltransferase ZDHHC12
    Names
    DHHC domain-containing cysteine-rich protein 12
    DHHC-12
    membrane-associated DHHC12 zinc finger protein
    probable palmitoyltransferase ZDHHC12
    zinc finger DHHC domain-containing protein 12
    zinc finger, DHHC domain containing 12
    zinc finger, DHHC-type containing 12
    NP_001013257.1
    XP_038961511.1
    XP_038961512.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013239.1NP_001013257.1  palmitoyltransferase ZDHHC12

      See identical proteins and their annotated locations for NP_001013257.1

      Status: PROVISIONAL

      Source sequence(s)
      BC076393
      UniProtKB/Swiss-Prot
      Q2TGJ7, Q6DGF5
      UniProtKB/TrEMBL
      A0A8L2QLS6, A6JTV1
      Related
      ENSRNOP00000039802.4, ENSRNOT00000050908.6
      Conserved Domains (1) summary
      pfam01529
      Location:123217
      DHHC; DHHC palmitoyltransferase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      33761338..33764207 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039105583.2XP_038961511.1  palmitoyltransferase ZDHHC12 isoform X1

      Conserved Domains (1) summary
      cl19890
      Location:156168
      DHHC; DHHC palmitoyltransferase
    2. XM_039105584.2XP_038961512.1  palmitoyltransferase ZDHHC12 isoform X2

      UniProtKB/TrEMBL
      A6JTV2
      Conserved Domains (1) summary
      pfam01529
      Location:35129
      DHHC; DHHC palmitoyltransferase