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    Cd72 Cd72 molecule [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313498, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cd72provided by RGD
    Official Full Name
    Cd72 moleculeprovided by RGD
    Primary source
    RGD:1309757
    See related
    EnsemblRapid:ENSRNOG00000017485 AllianceGenome:RGD:1309757
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in negative regulation of B cell receptor signaling pathway. Predicted to be active in plasma membrane. Orthologous to human CD72 (CD72 molecule). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 249.1), Testes (RPKM 90.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cd72 in Genome Data Viewer
    Location:
    5q22
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (62493155..62500779, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (57697361..57704980, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (58943021..58950373, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene ATPase, class I, type 8B, member 5 Neighboring gene uncharacterized LOC120102860 Neighboring gene RUN and SH3 domain containing 2 Neighboring gene ciliary microtubule inner protein 2B Neighboring gene uncharacterized LOC134486932 Neighboring gene testis associated actin remodelling kinase 1 Neighboring gene Rho guanine nucleotide exchange factor 39 Neighboring gene coiled-coil domain containing 107 Neighboring gene signaling threshold regulating transmembrane adaptor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The B-cell surface protein CD72/Lyb-2 is the ligand for CD5. Van de Velde H, et al. Nature, 1991 Jun 20. PMID 1711157
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC108873

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables transmembrane signaling receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of B cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    B-cell differentiation antigen CD72
    Names
    CD72 antigen

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001015016.1 → NP_001015016.1  B-cell differentiation antigen CD72

      See identical proteins and their annotated locations for NP_001015016.1

      Status: PROVISIONAL

      Source sequence(s)
      BC091196
      UniProtKB/TrEMBL
      Q5BK59
      Related
      ENSRNOP00000057186.2, ENSRNOT00000060442.6
      Conserved Domains (2) summary
      pfam05384
      Location:124 → 220
      DegS; Sensor protein DegS
      cl02432
      Location:230 → 296
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      62493155..62500779 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_005504445.2 RNA Sequence

    2. XR_005504446.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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