Hrob homologous recombination factor with OB-fold [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hrobprovided by RGD
Official Full Name: homologous recombination factor with OB-foldprovided by RGD
Primary source: RGD:1305385
See related: EnsemblRapid:ENSRNOG00000020908 AllianceGenome:RGD:1305385
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable single-stranded DNA binding activity. Predicted to be involved in DNA repair; female gamete generation; and male gamete generation. Predicted to be located in site of DNA damage. Orthologous to human HROB (homologous recombination factor with OB-fold). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 22.2), Thymus (RPKM 12.6) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.1

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (87705846..87722635)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (87206017..87222483)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (90192608..90214486)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables single-stranded DNA binding	IEA Inferred from Electronic Annotation more info
enables single-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables single-stranded DNA binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISS Inferred from Sequence or Structural Similarity more info
involved_in DNA synthesis involved in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in DNA synthesis involved in DNA repair	ISO Inferred from Sequence Orthology more info
involved_in DNA synthesis involved in DNA repair	ISS Inferred from Sequence or Structural Similarity more info
involved_in female gamete generation	IEA Inferred from Electronic Annotation more info
involved_in female gamete generation	ISO Inferred from Sequence Orthology more info
involved_in female gamete generation	ISS Inferred from Sequence or Structural Similarity more info
involved_in interstrand cross-link repair	IEA Inferred from Electronic Annotation more info
involved_in interstrand cross-link repair	ISO Inferred from Sequence Orthology more info
involved_in interstrand cross-link repair	ISS Inferred from Sequence or Structural Similarity more info
involved_in male gamete generation	IEA Inferred from Electronic Annotation more info
involved_in male gamete generation	ISO Inferred from Sequence Orthology more info
involved_in male gamete generation	ISS Inferred from Sequence or Structural Similarity more info
involved_in recombinational repair	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in site of DNA damage	IEA Inferred from Electronic Annotation more info
located_in site of DNA damage	ISO Inferred from Sequence Orthology more info
located_in site of DNA damage	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: homologous recombination OB-fold protein

Names: E2F1-inducible; uncharacterized protein C17orf53 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001017988.1 → NP_001017988.1 homologous recombination OB-fold protein

See identical proteins and their annotated locations for NP_001017988.1

Status: VALIDATED

Source sequence(s)

AY623029, AY623030, BE114522

UniProtKB/Swiss-Prot

Q6GX86, Q6GX87

Related

ENSRNOP00000063602.1, ENSRNOT00000065182.3

Conserved Domains (1) summary

pfam15072
Location:441 → 522

DUF4539; Domain of unknown function (DUF4539)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

87705846..87722635

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006247329.5 → XP_006247391.1 homologous recombination OB-fold protein isoform X1

See identical proteins and their annotated locations for XP_006247391.1

UniProtKB/TrEMBL

A0A0G2K9P1, A6HJH5

Related

ENSRNOP00000075073.1, ENSRNOT00000080965.3

Conserved Domains (1) summary

pfam15072
Location:458 → 539

DUF4539; Domain of unknown function (DUF4539)
XM_063269157.1 → XP_063125227.1 homologous recombination OB-fold protein isoform X5
XM_039086111.2 → XP_038942039.1 homologous recombination OB-fold protein isoform X5

Conserved Domains (1) summary

PHA03247
Location:215 → 374

PHA03247; large tegument protein UL36; Provisional
XM_039086108.2 → XP_038942036.1 homologous recombination OB-fold protein isoform X2

UniProtKB/TrEMBL

A0A8I6A3H9

Related

ENSRNOP00000086283.1, ENSRNOT00000103088.2

Conserved Domains (2) summary

PHA03247
Location:181 → 340

PHA03247; large tegument protein UL36; Provisional

pfam15072
Location:424 → 505

DUF4539; Domain of unknown function (DUF4539)
XM_039086109.2 → XP_038942037.1 homologous recombination OB-fold protein isoform X3

Conserved Domains (2) summary

PHA03247
Location:180 → 339

PHA03247; large tegument protein UL36; Provisional

pfam15072
Location:423 → 504

DUF4539; Domain of unknown function (DUF4539)
XM_039086110.2 → XP_038942038.1 homologous recombination OB-fold protein isoform X4

Related

ENSRNOP00000107729.1, ENSRNOT00000167474.1

Conserved Domains (2) summary

PHA03247
Location:135 → 294

PHA03247; large tegument protein UL36; Provisional

pfam15072
Location:378 → 459

DUF4539; Domain of unknown function (DUF4539)
XM_039086112.2 → XP_038942040.1 homologous recombination OB-fold protein isoform X6

Conserved Domains (1) summary

pfam15072
Location:75 → 156

DUF4539; Domain of unknown function (DUF4539)