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    Kcnh5 potassium voltage-gated channel subfamily H member 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171146, updated on 9-Dec-2024

    Summary

    Official Symbol
    Kcnh5provided by RGD
    Official Full Name
    potassium voltage-gated channel subfamily H member 5provided by RGD
    Primary source
    RGD:621417
    See related
    EnsemblRapid:ENSRNOG00000009542 AllianceGenome:RGD:621417
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Eag2
    Summary
    Enables delayed rectifier potassium channel activity and transmembrane transporter binding activity. Involved in potassium ion transport. Predicted to be located in cell surface. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy. Orthologous to human KCNH5 (potassium voltage-gated channel subfamily H member 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 96.8) See more
    Orthologs
    NEW
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    Genomic context

    See Kcnh5 in Genome Data Viewer
    Location:
    6q24
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (99350947..99643856, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (93615174..93908107, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (97872831..98157087, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479220 Neighboring gene uncharacterized LOC102550910 Neighboring gene synaptotagmin 16 Neighboring gene ras homolog family member J Neighboring gene glycoprotein hormone subunit beta 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables delayed rectifier potassium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables delayed rectifier potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables delayed rectifier potassium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transmembrane transporter binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables voltage-gated potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables voltage-gated potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables voltage-gated potassium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in potassium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in potassium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in potassium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within regulation of G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of voltage-gated potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of voltage-gated potassium channel complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    voltage-gated delayed rectifier potassium channel KCNH5; potassium voltage-gated channel subfamily H member 5
    Names
    ether-a-go-go potassium channel 2
    potassium channel, voltage gated eag related subfamily H, member 5
    potassium voltage-gated channel, subfamily H (eag-related), member 5
    rEAG2
    voltage-gated potassium channel subunit Kv10.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133610.2NP_598294.1  voltage-gated delayed rectifier potassium channel KCNH5

      See identical proteins and their annotated locations for NP_598294.1

      Status: PROVISIONAL

      Source sequence(s)
      AJ250280
      UniProtKB/Swiss-Prot
      O88893, Q9EPI9, Q9QXT2
      Related
      ENSRNOP00000013275.2, ENSRNOT00000013275.6
      Conserved Domains (3) summary
      PLN03192
      Location:217616
      PLN03192; Voltage-dependent potassium channel; Provisional
      COG0664
      Location:544723
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      pfam13426
      Location:39132
      PAS_9; PAS domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      99350947..99643856 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039111744.2XP_038967672.1  potassium voltage-gated channel subfamily H member 5 isoform X1

      UniProtKB/TrEMBL
      A6HC74
      Conserved Domains (2) summary
      PLN03192
      Location:14310
      PLN03192; Voltage-dependent potassium channel; Provisional
      cd00038
      Location:244354
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...