TARID TCF21 antisense RNA inducing promoter demethylation [Homo sapiens (human)] - Gene

Summary

Official Symbol: TARIDprovided by HGNC
Official Full Name: TCF21 antisense RNA inducing promoter demethylationprovided by HGNC
Primary source: HGNC:HGNC:50506
See related: Ensembl:ENSG00000227954 MIM:616058; AllianceGenome:HGNC:50506
Gene type: ncRNA
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: EYA4-AS1
Expression: Broad expression in placenta (RPKM 2.4), ovary (RPKM 2.4) and 16 other tissues See more
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Genomic context

Location:: 6q23.2

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (133502252..133889006, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (134691097..135077739, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (133823390..134210144, complement)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The long noncoding RNA TARID regulates the CXCL3/ERK/MAPK pathway in trophoblasts and is associated with preeclampsia.
Title: The long noncoding RNA TARID regulates the CXCL3/ERK/MAPK pathway in trophoblasts and is associated with preeclampsia.
LncRNA TARID induces cell proliferation through cell cycle pathway associated with coronary artery disease.
Title: LncRNA TARID induces cell proliferation through cell cycle pathway associated with coronary artery disease.
Results show that an antisense lncRNA, termed TARID (for TCF21 antisense RNA inducing demethylation), activates TCF21 expression by inducing promoter demethylation. TARID interacts with both the TCF21 promoter and GADD45A.
Title: Long noncoding RNA TARID directs demethylation and activation of the tumor suppressor TCF21 via GADD45A.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study identifies protein quantitative trait loci (pQTLs). EBI GWAS Catalog EBI GWAS CatalogPubMed
Common variants near MBNL1 and NKX2-5 are associated with infantile hypertrophic pyloric stenosis. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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General gene information

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Markers

SHGC-68688 (e-PCR)
- UniSTS:95549

RH36228 (e-PCR)
- UniSTS:10125

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.