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    spdi split discs [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31004, updated on 9-Dec-2024

    Summary

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    Official Symbol
    spdiprovided by FlyBase
    Official Full Name
    split discsprovided by FlyBase
    Primary source
    FLYBASE:FBgn0025633
    Locus tag
    Dmel_CG13366
    See related
    AllianceGenome:FB:FBgn0025633
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AAD55419; CG13366; Dmel\CG13366; EG:118B3.2
    Summary
    Involved in several processes, including adult somatic muscle development; notum morphogenesis; and sarcomere organization. Predicted to be part of filamentous actin. Predicted to be active in microtubule organizing center. Is expressed in spermatozoon. Human ortholog(s) of this gene implicated in Teebi hypertelorism syndrome 1 and oblique facial clefting 1. Orthologous to several human genes including SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1 like). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See spdi in Genome Data Viewer
    Location:
    1B10-1B12; 1-0 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (585081..620195, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (479114..514228, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene arginase Neighboring gene uncharacterized protein Neighboring gene beta amyloid protein precursor-like Neighboring gene mir-4960 stem loop Neighboring gene ventral nervous system defective Neighboring gene long non-coding RNA:CR45474 Neighboring gene pseudo Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Deficiency of the cytoskeletal protein SPECC1L leads to oblique facial clefting. Saadi I, et al. Am J Hum Genet, 2011 Jul 15. PMID 21703590, Free PMC Article
    2. Calponin homology domains at a glance. Korenbaum E, et al. J Cell Sci, 2002 Sep 15. PMID 12186940
    3. Parallel genetic and proteomic screens identify Msps as a CLASP-Abl pathway interactor in Drosophila. Lowery LA, et al. Genetics, 2010 Aug. PMID 20498300, Free PMC Article
    4. Hedgehog targets in the Drosophila embryo and the mechanisms that generate tissue-specific outputs of Hedgehog signaling. Biehs B, et al. Development, 2010 Nov. PMID 20978080, Free PMC Article
    5. Identification of genes associated with resilience/vulnerability to sleep deprivation and starvation in Drosophila. Thimgan MS, et al. Sleep, 2015 May 1. PMID 25409104, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adult somatic muscle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in notum morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proboscis morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sarcomere organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in wing disc development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of filamentous actin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    split discs
    Names
    CG13366-PA
    CG13366-PB
    CG13366-PC
    CG13366-PD
    CG13366-PE
    CG13366-PF
    CG13366-PG
    SPECC1L ortholog
    SPECC1L-ortholog
    spdi-PA
    spdi-PB
    spdi-PC
    spdi-PD
    spdi-PE
    spdi-PF
    spdi-PG

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      585081..620195 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001297820.1 → NP_001284749.1  split discs, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284749.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U4H0, X2J9Z8
      Conserved Domains (1) summary
      cd00014
      Location:848 → 917
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

    2. NM_001297817.1 → NP_001284746.1  split discs, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284746.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U4H0, X2JHS3
      Conserved Domains (1) summary
      cd00014
      Location:847 → 947
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

    3. NM_130492.3 → NP_569848.2  split discs, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_569848.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U4H0, Q9W5E8, Q9W5E9
      Related
      FBpp0070156
      Conserved Domains (1) summary
      cd00014
      Location:848 → 948
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

    4. NM_001297818.1 → NP_001284747.1  split discs, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284747.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U4H0, Q9W5E8, Q9W5E9
      Conserved Domains (1) summary
      cd00014
      Location:848 → 948
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

    5. NM_001042789.2 → NP_001036254.1  split discs, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036254.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C7LA68, Q0KHX7
      Conserved Domains (2) summary
      cd00014
      Location:992 → 1092
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam13935
      Location:554 → 684
      Ead_Ea22; Ead/Ea22-like protein

    6. NM_001297819.1 → NP_001284748.1  split discs, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284748.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C7LA68, Q0KHX7
      Conserved Domains (2) summary
      cd00014
      Location:992 → 1092
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam13935
      Location:554 → 684
      Ead_Ea22; Ead/Ea22-like protein

    7. NM_001297816.1 → NP_001284745.1  split discs, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284745.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C7LA68, Q0KHX7
      Conserved Domains (2) summary
      cd00014
      Location:992 → 1092
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam13935
      Location:554 → 684
      Ead_Ea22; Ead/Ea22-like protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O77431 O77431
    Q0KHX7 Q0KHX7
    Q9U4H0 Q9U4H0
    Q9W5E8 Q9W5E8
    X2J9Z8 X2J9Z8
    X2JHS3 X2JHS3

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